MRI: Acquisition of a Zeiss 880 Multiphoton and AiryScan Microscope System as a Shared Instrument for the Washington University Research Community

MRI：购买 Zeiss 880 多光子和 AiryScan 显微镜系统作为华盛顿大学研究界的共享仪器

• 批准号: 1828481
• 负责人: Ram Dixit
• 金额: $ 64.99万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828481&HistoricalAwards=false
• 关键词: MRI; Acquisition; Zeiss; 880; Multiphoton

An award is made to support the acquisition of a multiphoton confocal microscope to address the research needs of a large, diverse group of researchers in multiple departments at Washington University and in the St. Louis area. The new system will be housed in the Biology Department Imaging Core and will be readily accessible to university and regional users. The new imaging capabilities of this instrument will enable cutting edge multidisciplinary research and promote a well-prepared, diverse STEM workforce including students in underrepresented groups. The microscope will enhance the hands-on training of undergraduates through existing courses, in addition to the many Independent Study undergraduates that already use the Core. Furthermore, the instrument will enable the development of new teaching modules for other undergraduate biology classes where the need to procure data for many students in a short time frame precludes the use of existing instruments. This instrument will also have a large impact on underrepresented students involved in the Science Career Explorations programs, YMCA campus Y program for inner-city school children, and ENDURE program for underrepresented students entering neuroscience graduate school.The field of live cell imaging has recently enabled researchers to resolve physiological and molecular events in cells deep within tissues with micron- and millisecond-resolution. The new multiphoton system will provide deep, fast and super-resolution imaging technology for the first time to users in the departments of Biology, Physics, and Engineering at Washington University and from area institutions. Initial research uses for the new system will include work on cortical microtubules in plant cells; analysis of biosensors in root cells and pollen dynamics. Other researchers working with animal systems will study neuronal cell populations, tendon fascicles, and a range of other topics. Results from these studies will be published in peer-reviewed scientific journals, presented at scientific meetings, and used in both training and outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

一个奖项是为了支持多光子共聚焦显微镜的收购，以解决在华盛顿大学和圣路易斯地区的多个部门的一个大型，多样化的研究人员群体的研究需求。新系统将被安置在生物系成像核心，并将随时访问大学和区域用户。该仪器的新成像功能将使尖端的多学科研究成为可能，并促进一支准备充分的多元化STEM劳动力队伍，包括代表性不足的群体中的学生。显微镜将通过现有的课程加强本科生的实践培训，除了已经使用核心的许多独立研究本科生。此外，该仪器将使新的教学模块的其他本科生物类的需要，采购数据，许多学生在很短的时间内排除了使用现有的仪器的发展。该仪器还将对参与科学职业探索计划的代表性不足的学生产生重大影响，YMCA校园Y计划为市中心的学生提供帮助，ENDURE计划为进入神经科学研究生院的代表性不足的学生提供帮助。活细胞成像领域最近使研究人员能够以微米和毫秒分辨率解决组织深处细胞中的生理和分子事件。新的多光子系统将首次为华盛顿大学生物、物理和工程系以及地区机构的用户提供深度、快速和超分辨率成像技术。新系统的初步研究用途将包括植物细胞中皮层微管的研究;根细胞和花粉动力学中生物传感器的分析。 其他研究动物系统的研究人员将研究神经元细胞群，肌腱束和一系列其他主题。这些研究的结果将发表在同行评审的科学期刊上，在科学会议上发表，并用于培训和推广活动。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。