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PFC: Center for the Physics of Living Cells

PFC：活细胞物理中心

基本信息

批准号：
1430124
负责人：
Yann Chemla
金额：
$ 800万
依托单位：
University of Illinois at Urbana-Champaign
依托单位国家：
美国
项目类别：
Cooperative Agreement
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1430124&HistoricalAwards=false
关键词：
PFC Center Physics Living Cells

项目摘要

Describing complex living systems in a quantitative, physically-based manner is extremely difficult. Through this Physics Frontiers Centers award the Center for the Physics of Living Cells (CPLC) brings experimentalists and theorists together to address the technical challenges at the interface of physics and biology specifically on the cellular level. By the development and deployment of novel techniques from experimental, theoretical, and computational physics, the CPLC will create a dynamic narrative of living cells, expanding the physical description from molecular scales to whole cells and multicellular collections. Exploring such topics as real-time molecular mechanics and the statistical physics of intermediate size systems will inform and advance areas in both biology and physics. CPLC activities will foster the training and development of multidisciplinary scientists at the junction of physics and biology, including ''bootcamps'' and summer school workshops for undergraduate, graduate, and postdoctoral researchers. The CPLC will also operate diverse outreach programs targeting high school teachers and students, bilingual communities, and the general public.The CPLC seeks to transform the understanding of how cells function from molecular to macroscopic scales, communicate, respond to external stimuli, and even evolve. These goals will be approached through a variety of research activities including the development of new biophysical techniques that can measure individual molecules and cells and observe how cells interact to create new phenomena. Another activity concerns the quantification of intracellular complexity, including the measurement of RNA and protein dynamics. Further investigations involve probing how the properties of multicellular systems arise from the interactions of single cells. Experimentalists and theorists at the CPLC will collaborate closely to develop novel multi-scale computational tools to simulate systems on a wide range of times, scales, and complexity.This Physics Frontiers Centers award is co-funded by the Physics Frontiers Centers program in the Division of Physics and the Chemistry of Life Processes Program in the Division of Chemistry within the Directorate of Mathematical and Physical Sciences, and by the Molecular Biophysics program in the Division of Molecular and Cellular Biosciences within the Directorate for Biological Sciences.

以定量的、基于物理的方式描述复杂的生命系统是极其困难的。通过这个物理前沿中心奖，活细胞物理中心（CPLC）将实验学家和理论家聚集在一起，以解决物理学和生物学接口的技术挑战，特别是在细胞水平上。通过开发和部署实验，理论和计算物理学的新技术，CPLC将创建活细胞的动态叙述，将物理描述从分子尺度扩展到整个细胞和多细胞集合。探索实时分子力学和中等大小系统的统计物理等主题将为生物学和物理学领域提供信息和推进。CPLC活动将促进物理学和生物学交叉点的多学科科学家的培训和发展，包括为本科生、研究生和博士后研究人员举办的“训练营”和暑期学校讲习班。 CPLC还将针对高中教师和学生，双语社区和普通公众开展各种外展计划。CPLC旨在将细胞功能的理解从分子转变为宏观尺度，交流，对外部刺激的反应，甚至进化。这些目标将通过各种研究活动来实现，包括开发新的生物物理技术，可以测量单个分子和细胞，并观察细胞如何相互作用以创造新的现象。另一项活动涉及细胞内复杂性的定量，包括RNA和蛋白质动力学的测量。进一步的研究涉及探索多细胞系统的特性是如何从单细胞的相互作用中产生的。实验学家和理论家在CPLC将密切合作，开发新的多尺度计算工具，以模拟系统的时间，规模和复杂性范围广泛。这个物理前沿中心奖是共同资助的物理学前沿中心计划在物理和化学生命过程计划在化学部的数学和物理科学理事会，以及生物科学理事会分子和细胞生物科学部的分子生物物理学项目。

项目成果

期刊论文数量（34）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pin1 Binding to Phosphorylated PSD-95 Regulates the Number of Functional Excitatory Synapses

DOI：
10.3389/fnmol.2020.00010
发表时间：
2020-03-13
期刊：
FRONTIERS IN MOLECULAR NEUROSCIENCE
影响因子：
4.8
作者：
Delgado, Jary Y.;Nall, Duncan;Selvin, Paul R.
通讯作者：
Selvin, Paul R.

Escherichia coli with a Tunable Point Mutation Rate for Evolution Experiments

DOI：
10.1534/g3.120.401124
发表时间：
2020-06
期刊：
G3: Genes|Genomes|Genetics
影响因子：
0
作者：
Nicholas A. Sherer;T. Kuhlman
通讯作者：
Nicholas A. Sherer;T. Kuhlman

Multiple kinesins induce tension for smooth cargo transport.

多种驱动蛋白会产生张力，以实现货物顺利运输。

DOI：
10.7554/elife.50974
发表时间：
2019
期刊：
eLife
影响因子：
7.7
作者：
Tjioe,Marco;Shukla,Saurabh;Vaidya,Rohit;Troitskaia,Alice;Bookwalter,CarolS;Trybus,KathleenM;Chemla,YannR;Selvin,PaulR
通讯作者：
Selvin,PaulR

Light-controlled twister ribozyme with single-molecule detection resolves RNA function in time and space

DOI：
10.1073/pnas.2003425117
发表时间：
2020-06-02
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子：
11.1
作者：
Korman, Arthur;Sun, Huabing;Woodson, Sarah A.
通讯作者：
Woodson, Sarah A.

Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations