I-Corps: Development of Novel Technology for Nanoparticle Characterization

I-Corps：纳米颗粒表征新技术的开发

• 批准号: 1439183
• 负责人: Dariusz Stramski
• 金额: $ 5万
• 依托单位: University of California-San Diego Scripps Inst of Oceanography
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1439183&HistoricalAwards=false
• 关键词: Corps; Development; Novel; Technology; Nanoparticle

The PI and his group have developed an innovative technology named Multi-spectral Apparatus for Nanoparticle Tracking Analysis (MANTA) for accurate characterization of nanoparticle concentrations and sizes in an unperturbed state, which is relevant for many applications and research areas; for instance medical, pharmaceutical, biochemical, physical and environmental. Tests with nanoparticle standards demonstrate that MANTA outperforms existing commercial technologies. The superior performance of MANTA is due to novel approaches including sample illumination and video recording of nanoparticle Brownian motion and to proprietary algorithms and software for analysis of video data. MANTA is capable of providing information on nanoparticles meeting outstanding needs not currently met by the existing technologies and that affects a broad variety of industrial sectors/applications which utilize nanotechnology, such as manufacturing diagnostics, the printing, drilling, and milling industries, and the production of cosmetics, pigments, inks, catalysts, and textiles.Because measurements of concentration and size distribution of nanoparticles are essential to many applications as stated above, a range of potential customers for MANTA technology is large and diverse with no single typical customer profile. MANTA ensures that the concentration and size of nanoparticles are accurately determined over a broad range of nanoparticle sizes. The innovative solutions of MANTA thus represent a transformative advancement in the area of nanoparticle analysis and a major competitive advantage over existing technologies. The team expects that MANTA will have transformative effects in a broad range of health and environmental applications, including the diagnosis of disease and pathological conditions, development of efficient and specific therapies, environmental risk assessment, food safety, and occupational health and safety risk management strategies.

PI 和他的团队开发了一种名为多光谱纳米颗粒跟踪分析仪 (MANTA) 的创新技术，用于在不受干扰的状态下准确表征纳米颗粒的浓度和尺寸，这与许多应用和研究领域相关；例如医学、制药、生物化学、物理和环境。纳米颗粒标准测试表明 MANTA 优于现有商业技术。 MANTA 的卓越性能归功于新颖的方法，包括样品照明和纳米粒子布朗运动的视频记录，以及用于分析视频数据的专有算法和软件。 MANTA 能够提供有关纳米粒子的信息，满足现有技术目前无法满足的突出需求，并影响利用纳米技术的各种工业部门/应用，例如制造诊断、印刷、钻孔和铣削工业，以及化妆品、颜料、油墨、催化剂和纺织品的生产。因为纳米粒子的浓度和尺寸分布的测量对于 如上所述，MANTA 技术的潜在客户规模庞大且多样化，没有单一的典型客户概况。 MANTA 确保​​在广泛的纳米颗粒尺寸范围内准确测定纳米颗粒的浓度和尺寸。因此，MANTA 的创新解决方案代表了纳米颗粒分析领域的变革性进步，以及相对于现有技术的主要竞争优势。该团队预计MANTA将在广泛的健康和环境应用中产生变革性影响，包括疾病和病理状况的诊断、高效和特异性疗法的开发、环境风险评估、食品安全以及职业健康和安全风险管理策略。