PFI:AIR - TT: Miniaturization of Medical Oxygen Concentrators for Portable and Home Medical Applications

PFI:AIR - TT:用于便携式和家庭医疗应用的医用制氧机的小型化

基本信息

  • 批准号:
    1444963
  • 负责人:
  • 金额:
    $ 19.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-08-15 至 2017-07-31
  • 项目状态:
    已结题

项目摘要

This PFI: AIR Technology Translation project focuses on development of a self-contained compact prototype Medical Oxygen Concentrator (MOC) for use in oxygen rehabilitation therapy for patients suffering from Chronic Obstructive Pulmonary Disease (COPD), cystic fibrosis and other pulmonary diseases. The market for MOCs producing 1 to 8 liters/min of ~90 % oxygen from compressed ambient air is rapidly growing with an estimated global market in 2017 valued at ~$2 billion. The World Health Organization (WHO) estimates that more than 80 million people worldwide have COPD and nearly 3 million deaths per year can be attributed to COPD. A more compact and light-weight MOC design with substantially higher oxygen recovery and longer battery run-time will provide greater mobility to COPD patients for exercise, improved cardiovascular health and quality of life. This project seeks to meet this critical objective through the development of a fully functional self-contained prototype based on a novel patented Medical Oxygen Concentrator (MOC) design. Our MOC design has the following advantages: (1) it uses a single adsorption column inside a storage tank, as opposed to conventional two-bed rapid pressure swing adsorption processes (RPSA), thereby reducing size; (2) it uses fast cycle times in the range of 3-6 seconds to continuously produce up to 3 liters/min of ~90% oxygen from compressed air which is 3 times higher than the product delivery rate of commercial portable MOC units; (3) it uses less than one third of the adsorbent inventory for a given product flow rate; (4) it uses lesser number of switching valves and sensors and needs simpler process control for the single adsorption bed design due to the absence of synchronized operation of two or multi-column systems. (5) it provides more flexibility in selection and optimization of the individual step times of the RPSA process; (6) it allows continuous product withdrawal as opposed to pulsed product flow offered by many commercial portable units; (7) it is scalable in size and oxygen flow rates; (8) it can be used as a ?Snap On? device without a dedicated compressor in applications where a compressed air source is available, such as in hospitals (military or civil), cruise ships and airlines.Graduate and postdoctoral students will be trained on new concepts in technology transfer and business strategies beyond basic research. A master's student from the Technical Entrepreneurship program at Lehigh will benefit from incorporating our study in his/her capstone integrated business design project. Undergraduate Chemical Engineering seniors will conduct experiments that will integrate traditional chemical engineering principles across four years into a single comprehensive project as part of their Opportunities for Student Innovation course. The project will lead to comprehensive prototype performance data for enabling either a new start-up company or for a licensing agreement with a MOC manufacturer for commercialization.
该 PFI:AIR 技术翻译项目的重点是开发一种独立的紧凑型原型医用制氧机 (MOC),用于患有慢性阻塞性肺病 (COPD)、囊性纤维化和其他肺部疾病的患者的氧气康复治疗。从压缩环境空气中生产 1 至 8 升/分钟约 90% 氧气的 MOC 市场正在快速增长,预计 2017 年全球市场价值约 20 亿美元。世界卫生组织 (WHO) 估计,全球有超过 8000 万人患有慢性阻塞性肺病,每年有近 300 万人死于慢性阻塞性肺病。更紧凑、更轻的 MOC 设计具有更高的氧气回收率和更长的电池运行时间,将为 COPD 患者提供更大的运动灵活性,改善心血管健康和生活质量。该项目旨在通过开发基于新型专利医用氧气浓缩器 (MOC) 设计的功能齐全的独立原型来实现这一关键目标。我们的MOC设计具有以下优点:(1)它在储罐内使用单个吸附塔,而不是传统的两床快速变压吸附工艺(RPSA),从而减小了尺寸; (2) 它采用 3-6 秒范围内的快速循环时间,从压缩空气中连续生产高达 3 升/分钟的约 90% 氧气,比商用便携式 MOC 装置的产品输送率高出 3 倍; (3) 对于给定的产品流量,其使用的吸附剂库存少于三分之一; (4)由于没有两塔或多塔系统的同步操作,单吸附床设计使用较少数量的切换阀和传感器,并且需要更简单的过程控制。 (5)在RPSA工艺的各个步骤时间的选择和优化方面提供了更大的灵活性; (6) 它允许连续的产品提取,而不是许多商业便携式装置提供的脉冲产品流; (7)尺寸和氧气流量可扩展; (8) 它可以用作“Snap On”?在有压缩空气源的应用中,例如医院(军用或民用)、游轮和航空公司,无需专用压缩机的设备。研究生和博士后学生将接受基础研究之外的技术转让和商业策略新概念的培训。里哈伊大学技术创业项目的硕士生将受益于将我们的研究纳入他/她的顶点综合商业设计项目。化学工程本科生将进行实验,将四年的传统化学工程原理整合到一个综合项目中,作为学生创新机会课程的一部分。 该项目将产生全面的原型性能数据,以支持新的初创公司或与 MOC 制造商签订商业化许可协议。

项目成果

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Mayuresh Kothare其他文献

An event-based neural partial differential equation model of heat and mass transport in an industrial drying oven
工业干燥炉中热质传递的基于事件的神经偏微分方程模型
  • DOI:
    10.1016/j.compchemeng.2025.109171
  • 发表时间:
    2025-09-01
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Siddharth Prabhu;Sulman Haque;Dan Gurr;Loren Coley;Jim Beilstein;Srinivas Rangarajan;Mayuresh Kothare
  • 通讯作者:
    Mayuresh Kothare

Mayuresh Kothare的其他文献

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{{ truncateString('Mayuresh Kothare', 18)}}的其他基金

I-Corps: A Prototype Design and Market Evaluation of Miniaturized Medical Oxygen Concentrator
I-Corps:小型医用制氧机的原型设计和市场评估
  • 批准号:
    1402128
  • 财政年份:
    2014
  • 资助金额:
    $ 19.99万
  • 项目类别:
    Standard Grant
Collaborative Research: CDI Type I: Optimal and predictive control of neural prostheses using intracortical Brain Machine Interfaces
合作研究:CDI I 型:使用皮质内脑机接口对神经假体进行优化和预测控制
  • 批准号:
    0835632
  • 财政年份:
    2008
  • 资助金额:
    $ 19.99万
  • 项目类别:
    Standard Grant
CAREER: Dynamics and Control of Integrated Microchemical Systems
职业:集成微化学系统的动力学和控制
  • 批准号:
    0134102
  • 财政年份:
    2002
  • 资助金额:
    $ 19.99万
  • 项目类别:
    Standard Grant
An Integrated Chemical Reforming Microplant for Fuel Cell Applications
用于燃料电池应用的集成化学重整微型装置
  • 批准号:
    9980781
  • 财政年份:
    1999
  • 资助金额:
    $ 19.99万
  • 项目类别:
    Standard Grant

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