EAGER: Portable photoacoustic platform for glucose sensing

EAGER：用于葡萄糖传感的便携式光声平台

• 批准号: 1445342
• 负责人: Sergey Mirov
• 金额: $ 29.99万
• 依托单位: University of Alabama at Birmingham
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1445342&HistoricalAwards=false
• 关键词: EAGER; Portable; photoacoustic; platform; glucose

Proposal: 1445342PI: Mirov, SergeyUniversity: University of Alabama at BirminghamTitle: EAGER: Portable photoacoustic platform for glucose sensingThe PI proposes to develop and build a working prototype of a true noninvasive, portable hand held, low cost device for blood glucose level monitoring in home or clinic settings. If successful, this device will substantially improve the quality of life of millions of people with diabetes by eliminating discomfort and pain associated with the necessity to puncture fingers, and reduce the probability of developing chronic diabetes complications due to poor management of blood glucose levels. The device could be also used for continuous blood glucose level monitoring in clinic and hospital settings. The proposed platform can also be used for development of other applications such as detection and monitoring of chemicals of interest in aqueous solutions for environmental studies, and in industrial settings.The device will be based on a wavelength modulation (WM) photoacoustic (PA) spectroscopy in the near-infra-red (IR) spectral region. It will consist of a portable acoustic cell, a portable broadly tunable diode pumped Cr:ZnSe laser, pioneered by the PI group, and a smartphone for measurements control and data analysis. This novel wavelength modulation technique is essentially a zero background method, which will substantially improve sensitivity of current photoacoustic methods for glucose level monitoring. The absence of a strong background due to water absorption will not only improve sensitivity of the device, but also eliminate the necessity to perform arduous data treatment algorithms for extracting weak glucose absorption signals masked under a strong background. This will enable the use of devices with low computational power, such as smartphones.

提案：1445342 PI：Mirov，Sergey 大学：阿拉巴马大学伯明翰分校 标题：EAGER：用于葡萄糖传感的便携式光声平台 PI 建议开发和构建一个真正的无创、便携式手持、低成本设备的工作原型，用于家庭或诊所环境中的血糖水平监测。如果成功，该设备将消除与穿刺手指相关的不适和疼痛，从而显着改善数百万糖尿病患者的生活质量，并降低因血糖水平管理不善而出现慢性糖尿病并发症的可能性。该设备还可用于诊所和医院环境中的连续血糖水平监测。所提出的平台还可用于开发其他应用，例如环境研究和工业环境中水溶液中感兴趣的化学物质的检测和监测。该设备将基于近红外（IR）光谱区域的波长调制（WM）光声（PA）光谱。它将由 PI 小组首创的便携式声学单元、便携式宽可调二极管泵浦 Cr:ZnSe 激光器以及用于测量控制和数据分析的智能手机组成。这种新颖的波长调制技术本质上是一种零背景方法，它将大大提高当前用于血糖水平监测的光声方法的灵敏度。由于吸水而消除强背景不仅会提高设备的灵敏度，而且还消除了执行繁琐的数据处理算法以提取强背景下掩盖的微弱葡萄糖吸收信号的必要性。这将使计算能力较低的设备（例如智能手机）的使用成为可能。