NSF Convergence Accelerator Track L: Portable Quantum-enhanced Sensing and Species Identification of Bioaerosols

NSF 融合加速器轨道 L：生物气溶胶的便携式量子增强传感和物种识别

• 批准号: 2344350
• 负责人: Prineha Narang
• 金额: $ 65万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2344350&HistoricalAwards=false
• 关键词: NSF; Convergence; Accelerator; Track; Portable

Bioaerosols encompass diverse classes of airborne particles that contain materials of biological origin including bacteria, viruses, pollen, archaea, fungi, and their fragments and byproducts. Bioaerosols directly impact short-term and long-term human, animal, plant, and climate health, viability, and associated economies of scale. Despite their importance, estimates of global mass emissions of bioaerosols have uncertainties of 1-2 orders of magnitude and identifying specific species and their origins in bioaerosols remains difficult. This project involves the development of a convergent, real-world chemical sensing approach to advance understanding of the origins and temporal evolution of bioaerosols, and guide their mitigation, when needed. This project will advance the technology readiness level of sensor technologies targeting bioaerosols and deliver prototypes of a suite of sensors essential for bioaerosol identification. By developing multimodal, field-deployable bioaerosol sensors, this research holds the potential to reduce the spread of infectious diseases, allergens, and antibiotic-resistant genes and organisms. The team will leverage joint projects with the National Oceanic and Atmospheric Administration, the Defense Threat Reduction Agency, federally funded research and development centers, including NASA's Jet Propulsion Laboratory and the National Insitute of Standards and Technology, and include strategic translation partners in the US private sector in space, aerospace, and remote sensing. This effort also will develop a highly qualified, diverse workforce, building on a track-record of non-traditional education programs, creating opportunities for historically underrepresented groups at Cal State campuses, and establishing professional development programming in collaboration with industry, startups, and non-academic stakeholders in atmospheric chemistry, remote sensing and geosciences.This multidisciplinary Accelerator team will develop, test, optimize, and combine transistor-based portable biosensors and quantum-enhanced sensors to achieve highly sensitive, high-speed, remote, multiplexed, multimodal, and in situ measurements of bioaerosols, including identifying microorganism species. The team brings together the sensor developers with the sensor end users via engineered prototypes to address a pressing challenge in real-world chemical sensing: bioaerosols. In Phase I, this program will demonstrate a prototype of a suite of sensors: (1) a portable electronic direct-detection sensor capable of quantifying the presence of multiple microorganisms in bioaerosols based on their genetic signatures with a 1000-copy-number or lower limit of detection, (2) an integrated terahertz sensor based on quantum-logic spectroscopy of molecular ions that can perform in-situ detection and identification of bioaerosols in the field, and (3) a dual-comb spectrometer using on-chip frequency combs for bioaerosol identification in the field. These sensors will be supported by the development of a frequency-locked optical whispering evanescent resonator (FLOWER) platform and hyperspectral unmixing and sensor data fusion techniques. In Phase II, this program will partner with industry and non-profit stakeholders to commercialize and deploy these sensors in the field.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物美感包括包括细菌，病毒，花粉，古细菌，真菌及其碎片和副产品的生物来源材料的各种机载颗粒类别。生物美感直接影响短期和长期的人，动物，植物和气候健康，生存能力以及相关规模经济。尽管它们的重要性，但对生物溶质的全球质量排放的估计值不确定为1-2个数量级，并且确定特定物种及其在生物溶质中的起源仍然很困难。该项目涉及开发一种收敛的，现实世界中的化学传感方法，以提高对生物溶质的起源和时间演变的理解，并在需要时指导其缓解措施。该项目将提高针对生物溶质的传感器技术的技术准备水平，并提供对生物溶质识别必不可少的一组传感器的原型。通过开发多模式，可剥离的生物素传感器，该研究具有减少传染病，过敏原和抗生素耐药基因和生物体的传播的潜力。该小组将利用与国家海洋和大气管理局，国防威胁局，联邦资助的研发中心（包括NASA的Jet Propulsion Laboratory和National Insitute sanditute of Standits of Standitds of Standits of Standitds of Standits of Strescition Translation合作伙伴）的联合项目。这项努力还将在非传统教育计划的田径录制基础上建立高度合格，多样化的劳动力，为在CAL州立校园里为历史上代表性不足的团体创造机会，并与行业，初创公司和非核次优化的企业中的远程化学和地理学团队合作建立专业发展计划。基于晶体管的便携式生物传感器和量子增强的传感器，以实现高度敏感，高速，远程，多路复用，多模式和原位测量生物溶质溶质的测量，包括识别微生物物种。团队通过工程原型将传感器开发人员与传感器最终用户汇集在一起​​，以应对现实世界化学传感的紧迫挑战：Bioaerosols。在第一阶段，该程序将展示一套传感器套件的原型：（1）一种可移植的电子直接检测传感器，能够基于其基于1000拷贝数量或下限的检测量的遗传学特征来量化生物溶胶中多种微生物的存在，（2）基于整合的Terahertz传感器，（2）基于量子量的传感器，（2）原地的原位检测和鉴定该田间的生物溶质，（3）使用片上频率梳子的双弯曲光谱仪在现场中识别生物Aerosol鉴定。这些传感器将通过开发频率锁定的光窃窃私语谐振器（花）平台以及高光谱透明和传感器数据融合技术来支持这些传感器。在第二阶段，该计划将与行业和非营利利益相关者合作，以将这些传感器商业化和部署在现场中。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，认为值得通过评估来获得支持。