I-Corps: Effective protection against damage to crops in drought conditions.

I-Corps：有效保护农作物免受干旱条件下的损害。

• 批准号: 1449652
• 负责人: Hemayet Ullah
• 金额: $ 5万
• 依托单位: Howard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1449652&HistoricalAwards=false
• 关键词: Corps; Effective; protection; against; damage

Development of crop plants that can withstand drought and salt stresses is at the forefront of plant science-based scientific endeavors. Genetic modification-based approaches have shown the potential to develop such plants, however, inherent complications and lack of wide spread acceptability of GMO foods hinder advancement. A transformative idea would be to regulate environmental stress responses in crop plants by applying fertilizer-like small compounds. In this proposal, the team has developed a series of potentially valuable agrichemicals that should help with drought tolerance, so there could be very substantial commercial potential for the products.The PI and his team have isolated dozens of small compounds targeting the functional domain of a well characterized scaffold protein RACK1A in the model plant Arabidopsis. One of the compounds- SD29 has shown to confer drought/salt stress resistance in the model plant Arabidopsis. In addition preliminary studies have shown that it protects under other stress conditions as well. Another compound developed can enable crop plants to maintain photosynthesis even under environmental stresses like drought/salt stresses. Considering the global climate change and effort to increase biomass for biofuel production, the proposed chemical compounds have great potential to contribute in many economic and environmental fronts. The successful demonstration of this new RACK1 inhibitors chemical provides safe and effective protection against damage to crops in drought/salty conditions.

培育能够抵御干旱和盐胁迫的作物是植物科学基础科学努力的前沿。基于遗传修饰的方法已经显示出开发这种植物的潜力，然而，固有的复杂性和转基因食品缺乏广泛的可接受性阻碍了进展。一个变革性的想法是通过施用类似肥料的小化合物来调节作物对环境胁迫的反应。 在这项提案中，该团队已经开发出一系列具有潜在价值的农用化学品，这些化学品应该有助于耐旱，因此这些产品可能具有非常巨大的商业潜力。PI和他的团队已经分离出数十种小化合物，这些化合物靶向模型植物拟南芥中一种特征良好的支架蛋白RACK 1A的功能域。其中一种化合物-SD 29已显示在模式植物拟南芥中赋予干旱/盐胁迫抗性。此外，初步研究表明，它在其他压力条件下也有保护作用。 开发的另一种化合物可以使作物即使在干旱/盐胁迫等环境胁迫下也能保持光合作用。考虑到全球气候变化和努力增加生物质用于生物燃料生产，所提出的化合物具有在许多经济和环境方面做出贡献的巨大潜力。这种新型RACK 1抑制剂化学品的成功展示为干旱/盐碱条件下的作物提供了安全有效的保护。