Synaptic signal transmission and neuronal physiological characteristics of auditory brainstem neurons measured in vivo.

体内测量的听觉脑干神经元的突触信号传递和神经元生理特征。

• 批准号: 218093275
• 负责人: Professor Dr. Rudolf Rübsamen
• 金额: --
• 依托单位: Research Academy Leipzig
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/218093275?language=en
• 关键词: Synaptic; signal; transmission; neuronal; physiological

A number of projects in the planned priority program will investigate wildtype mice and genetically engineered mice strains and aim at studying the contribution of defined cellular components of the auditory system or of specific physiological properties to the overall performance of the auditory system. Here, we propose an integral project that will complement these highly focused projects by providing the infrastructure and resources to acquire in vivo electrophysiological data from auditory brainstem nuclei which might aid the conclusiveness of some experimental projects. The data acquisition and the analysis outlined in this proposal is a relatively new approach for studying the auditory brainstem. It combines the in vivo approach, i.e. studying the mostly undisturbed system with (almost) the analytical depth of studying cellular systems. We want to make this methodological approach available for other research groups of the priority program and at the same time contribute strongly to the networking within this consortium. While both the experimental procedures and the methods of analysis are thoroughly documented in a number of publications, the direct path to the masterful use of this approach is through collaboration on a specific topic. This task should be accomplished during the first funding period of the SPP and consequently the funding of this project should be limited to period.

计划优先计划中的一些项目将调查野生型小鼠和基因工程小鼠品系，旨在研究听觉系统的特定细胞组件或特定生理特性对听觉系统整体性能的贡献。在这里，我们提出了一个完整的项目，通过提供基础设施和资源来从听觉脑干核团中获取在体电生理数据，从而补充这些高度集中的项目，这可能有助于某些实验项目的结论。这项建议中概述的数据获取和分析是研究听觉脑干的一种相对较新的方法。它结合了体内的方法，即研究最不受干扰的系统和(几乎)研究细胞系统的分析深度。我们希望将这种方法方法提供给优先计划的其他研究小组，同时为该联盟内的联网做出强有力的贡献。虽然实验程序和分析方法都在一些出版物中得到了详细的记录，但掌握这一方法的直接途径是通过在特定主题上进行合作。这项任务应在战略计划的第一个资助期内完成，因此，该项目的资助额应限于一定的资助期。