BRAIN EAGER: "ECOSTIM-MR"-Novel Multimodal Approach for High-Resolution Brain Research
BRAIN EAGER:“ECOSTIM-MR”——用于高分辨率大脑研究的新型多模态方法
基本信息
- 批准号:1450960
- 负责人:
- 金额:$ 30万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-15 至 2016-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A Novel Multimodal Approach for High-Resolution Brain ResearchThe objective of this research program is to develop a novel methodology and analytic strategy for simultaneous high-density intracranial electrophysiological recording, electrical brain stimulation, and optogenetic activation/deactivation during high-field functional magnetic resonance imaging, and to apply this integrated methodology to investigate neural mechanisms that mediate sensory processing and selective attention in macaque. The project will advance discovery and understanding while promoting teaching and training by involving graduate students and postdoctoral scholars in undergraduate research supervision related to the project. Because selective attention is a core cognitive process, elucidating attentional mechanisms close relatives to humans such as the macaque remains a high priority in efforts to understand, diagnose and treat psychiatric conditions that involve deficits in attention, such as attention deficit hyperactivity disorder (ADHD), autism, obsessive compulsive disorder (OCD) and schizophrenia. All of our conscious perceptions and cognitive actions depend critically on the neural computations performed by cortical circuits, the network of connections made by neurons in the cerebral cortex. Given the central importance of cortical circuits in mediating complex behavior, it is critical that we have the tools necessary to study these circuits during behavior. No single method of recording brain activity is yet able to characterize both the functional anatomy and rapid temporal changes in neuronal activity with both high spatial and temporal resolution. However, by the integration of different methods with either high temporal or high spatial resolution, this research will develop tools capable of providing a view of the time course and functional anatomy of brain circuits supporting behavior.
一种新的用于高分辨率脑研究的多模式方法本研究计划的目标是开发一种新的方法学和分析策略,在高场功能磁共振成像过程中同时进行高密度脑电生理记录、脑电刺激和光遗传激活/去激活,并应用这种综合方法学来研究调节猕猴感觉加工和选择性注意的神经机制。该项目将通过让研究生和博士后学者参与与该项目相关的本科生研究指导,在促进教学和培训的同时促进发现和理解。由于选择性注意力是一种核心的认知过程,因此在理解、诊断和治疗涉及注意力缺陷的精神疾病方面,阐明与猕猴等人类亲缘关系密切的注意力机制仍然是高度优先的任务,如注意力缺陷多动障碍(ADHD)、自闭症、强迫症(OCD)和精神分裂症。我们所有的有意识的感知和认知行为在很大程度上依赖于由大脑皮层神经元建立的连接网络--大脑皮层回路--执行的神经计算。鉴于大脑皮层回路在调节复杂行为中的核心重要性,我们拥有必要的工具来研究行为过程中的这些回路是至关重要的。目前还没有一种单一的记录大脑活动的方法能够同时以高空间和时间分辨率表征神经活动的功能解剖和快速时间变化。然而,通过整合高时间或高空间分辨率的不同方法,这项研究将开发能够提供支持行为的大脑回路的时间进程和功能解剖的视图的工具。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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W. Martin Usrey其他文献
W. Martin Usrey的其他文献
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{{ truncateString('W. Martin Usrey', 18)}}的其他基金
Conference: 2018 Thalamocortical Interactions GRC: Development, Function and Dysfunction of Thalamocortical Networks, Lucca, Italy, February 2018
会议:2018 丘脑皮质相互作用 GRC:丘脑皮质网络的发展、功能和功能障碍,意大利卢卡,2018 年 2 月
- 批准号:
1807140 - 财政年份:2018
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Gordon Research Conference, Thalamocortical Interactions: Cell and Circuit Properties. Meeting, February 14-19, 2016, Ventura, CA
戈登研究会议,丘脑皮质相互作用:细胞和电路特性。
- 批准号:
1550293 - 财政年份:2015
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Mechanisms of Attention in Early Visual Processing
早期视觉处理中的注意力机制
- 批准号:
1228535 - 财政年份:2012
- 资助金额:
$ 30万 - 项目类别:
Continuing Grant
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