Model-oriented treatment of word production disorders in aphasia

失语症言语产生障碍的模型导向治疗

• 批准号: 21828035
• 负责人: Professor Dr. Walter Huber
• 金额: --
• 依托单位: Klinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/21828035?language=en
• 关键词: Model; oriented; treatment; word; production

In this project, we investigate model-oriented treatment of word production disorders in chronic aphasia. Patients receive lexical access training that aims at the underlying lexical deficit in picture naming. Its intensity complies with the principle of massed practice (Pulvermüller et al., 2001). Assessment of the deficit is accomplished by applying a connectionist model to picture naming performance before and after training (see Abel et al., 2005): The interactive activation model of Foygel & Dell (2000) specifies two steps in picture naming - access of lemmas (semantically specified word units) and access of phonemes (sound units). The model is connectionist in nature, i.e. the disorder is simulated by a computer program that automatically attributes the impairment to one or both lexical access steps (connectionist diagnosis). Using a lexical activation fMRIparadigm in which both levels of processing are activated as separately as possible, processing in overt naming can be examined in the normal brain, and in the lesioned brain before and after therapy (for overview, see Indefrey & Levelt, 2000; Grande & Huber, 2005). Therefore, ¿lesions¿ and ¿recovery¿ are analyzed via the cognitive model and the brain, aiming at understanding the processes underlying recovery and trying to link both levels of explanation.

在这个项目中，我们调查模型导向的治疗慢性失语症的单词产生障碍。患者接受词汇通达训练，目的是在图片命名的潜在词汇缺陷。其强度符合大规模实践的原则（Pulvermüller等人，2001年）。通过在训练之前和之后将联结模型应用于图片命名表现来完成对缺陷的评估（参见Abel等人，2005年）：Foygel & Dell（2000）的交互激活模型指定了图片命名的两个步骤-词元的访问（语义指定的单词单位）和音素的访问（声音单位）。该模型本质上是连接主义的，即通过计算机程序模拟障碍，自动将障碍归因于一个或两个词汇访问步骤（连接主义诊断）。使用词汇激活fMRI范式，其中两个级别的处理尽可能单独激活，可以在正常大脑中检查公开命名的处理，以及在治疗前后的受损大脑中（概述，参见Indefrey & Levelt，2000; Grande & Huber，2005）。因此，病变然后，回收通过认知模型和大脑进行分析，旨在理解恢复的潜在过程，并试图将两个层次的解释联系起来。