Characterisation of insulin-independent glucose uptake mediated by guanine nucleotide-binding proteins (G-proteins) coupled receptors

鸟嘌呤核苷酸结合蛋白（G 蛋白）偶联受体介导的胰岛素非依赖性葡萄糖摄取的表征

• 批准号: LX0989791
• 负责人: Prof Roger Summers
• 金额: $ 5.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0989791
• 关键词: Characterisation; insulin; independent; glucose; uptake

This project will provide first class postdoctoral training for Dr Sato in the laboratory of A/Prof Bengtsson one of the pioneers in the field of cell metabolism. He will learn new approaches to the study of cell signalling including the use of ribonucleic acid interference (RNAi) technologies and of a series of functionally altered mutants of phosphatidylinositol (PI) 3-kinase that he will bring back to Monash University. A better understanding of the cell signalling mechanisms involved in glucose transport will be of enormous benefit in developing new approaches to the treatment of diseases such as type II diabetes.

该项目将在细胞代谢领域的先驱之一Bengtsson教授的实验室为Sato博士提供一流的博士后培训。他将学习研究细胞信号的新方法，包括使用核糖核酸干扰（RNAi）技术和一系列功能改变的磷脂酰肌醇（PI）3-激酶突变体，他将带回莫纳什大学。更好地了解葡萄糖转运中涉及的细胞信号传导机制将对开发治疗II型糖尿病等疾病的新方法具有巨大的益处。