Understanding cell signalling mechanisms activated by relaxin family peptides: targets with therapeutic potential

了解松弛素家族肽激活的细胞信号传导机制：具有治疗潜力的靶点

• 批准号: nhmrc : 436713
• 负责人: Prof Roger Summers
• 金额: $ 20.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-cell-signalling-therapeutic-potential/82197
• 关键词: Understanding; cell; signalling; mechanisms; activated

One of the most powerful ways that the activity of the cells that make up the tissues and organs of the body can be changed is by the interaction of chemicals with proteins called receptors located at the cell surface. The commonest type of receptor is called a G-protein coupled receptor as it is linked to mechanisms inside the cell by the G-proteins. These receptors are the most commonly targeted by pharmaceutical companies that wish to alter the responses of cells for therapeutic purposes and almost 2-3 of all drugs currently marketed work through these proteins. This project will examine the mechanisms whereby certain types of G-protein coupled receptor produce signals in cells and determine what are the critical areas of the receptor for these interactions. The receptors involved have been discovered only in the last 4 years and little is known of the ways these change the activity of cells. The substances acting on these receptors have potential for development as targets for drugs that have the potential to treat fibrosis which is a feature of many diseases including cardiac failure, kidney failure and lung disease.

改变构成人体组织和器官的细胞活动的最有力的方法之一是通过化学物质与位于细胞表面的被称为受体的蛋白质的相互作用。最常见的受体被称为g蛋白偶联受体，因为它通过g蛋白与细胞内的机制联系在一起。这些受体是制药公司希望改变细胞反应以达到治疗目的的最常见目标，目前市场上几乎2-3的药物都是通过这些蛋白质起作用的。该项目将研究某些类型的g蛋白偶联受体在细胞中产生信号的机制，并确定受体在这些相互作用中的关键区域。相关的受体直到最近4年才被发现，人们对这些受体改变细胞活性的方式知之甚少。作用于这些受体的物质有潜力成为治疗纤维化的药物靶点，纤维化是许多疾病的特征，包括心力衰竭、肾衰竭和肺部疾病。