Discovery of Organic and Organometallic Intermediates

有机和有机金属中间体的发现

• 批准号: 1464538
• 负责人: Paul Williard
• 金额: $ 45万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464538&HistoricalAwards=false
• 关键词: Discovery; Organic; Organometallic; Intermediates

With this award, the Chemical Structure, Dynamics and Mechanism B program supports fundamental research of Professor Williard at Brown University. Professor Williard will develop a fast, accurate, sensitive and quantitative assessment of the molecular weight of chemical compounds in solution utilizing nuclear magnetic resonance measurements. This technique provides a rapid evaluation of chemical compounds and processes including rapid assessment of new electrolytes for lithium ion batteries (LIB), rapid monitoring of biodiesel fuel formation from used cooking oils, high throughput screening of new pharmaceuticals, and real time analysis of industrially important, bulk-scale chemical reactions such as polymerization and catalytic processes. It is applicable to small, medium and large molecules. Professor Williard in conjunction with the Leadership Alliance - a national organization based in Providence, RI that actively identifies, encourages and supports underrepresented minority student participation in research projects - with support from this grant and encouragement from the chairs of the chemistry departments at Brown University and at Claflin University in Orangeburg, SC will visit Claflin and teach a course on modern structure determination emphasizing the techniques developed in this project. Both faculty and students from Claflin will participate in exchange visits designed to foster increased collaboration between the largely minority student and faculty at Claflin with this research at Brown University.Nuclear magnetic resonance (NMR), referred to as diffusion oriented spectroscopy or DOSY, will be enhanced and tuned for the characterization and discovery of new and existing alkali metal compounds, transition metal clusters, and alternative energy fuels derived from carbon dioxide. This specific technique utilizes pulsed gradient radio frequency (rf) fields to determine diffusion characteristics of analytes in solution. The methodology will be developed with the goal of improving the efficiency of the chemical reactions in which organic, organometallic and macromolecular compounds participate. An important aspect of the proposed project is that it will enhance diffusion-formula weight analysis (D-FW) with improvements in the sensitivity of pure shift NMR experiments. Single crystal x-ray diffraction analysis (XRD) will be performed in conjunction with the solution phase structure determination where applicable to corroborate and to complement NMR analyses.

有了这个奖项，化学结构，动力学和机制B计划支持布朗大学教授Williard的基础研究。 Williard教授将开发一种快速，准确，灵敏和定量的评估化学化合物的分子量在溶液中利用核磁共振测量。 该技术提供了化合物和过程的快速评估，包括锂离子电池（LIB）新电解质的快速评估、用过的食用油形成生物柴油燃料的快速监测、新药物的高通量筛选以及工业上重要的大规模化学反应（如聚合和催化过程）的真实的时间分析。它适用于小、中、大分子。 Williard教授与领导力联盟-一个总部设在普罗维登斯的国家组织，积极识别，鼓励和支持代表性不足的少数民族学生参与研究项目-在布朗大学和奥兰治堡的克拉夫林大学化学系主任的支持和鼓励下，SC将访问克拉夫林，并教授一门关于现代结构测定的课程，重点是该项目中开发的技术。 克拉夫林的师生都将参加交流访问，旨在促进克拉夫林的大部分少数民族学生和教师与布朗大学的这项研究之间的合作。核磁共振（NMR），被称为扩散导向光谱或DOSY，将得到增强和调整，用于表征和发现新的和现有的碱金属化合物，过渡金属簇，以及从二氧化碳中提取的替代能源燃料。 这种特定的技术利用脉冲梯度射频（rf）场来确定溶液中分析物的扩散特性。 该方法将被开发的目标是提高有机，有机金属和大分子化合物参与的化学反应的效率。 拟议项目的一个重要方面是，它将加强扩散公式重量分析（D-FW）与纯位移NMR实验的灵敏度的改进。 单晶X射线衍射分析（XRD）将与溶液相结构测定一起进行（如适用），以确证和补充NMR分析。