Identification of Organometallic Complexes for Organic Synthesis by Diffusion NMR

通过扩散核磁共振鉴定有机合成用有机金属配合物

• 批准号: 1058051
• 负责人: Paul Williard
• 金额: $ 40万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-10-01 至 2014-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058051&HistoricalAwards=false
• 关键词: Identification; Organometallic; Complexes; Organic; Synthesis

The Chemical Structure, Dynamics and Mechanisms Program supports Professor Paul G. Williard at Brown University who will provide greater understanding of the solution structure and reactivity of important organometallic reagents while further expanding the utility of the Diffusion-Ordered NMR Spectroscopy (DOSY) method. Professor Williard describes the continued development and application of DOSY with respect to understanding aggregation of organometallic reagents used broadly in synthetic chemistry and outlines its extension to other unrelated systems showing the range and potential for the method. The research proposed includes topics such as, ligand and solvent exchange processes in organolithium reagents, diffusion across membranes, examination of membranes for battery applications, mixed aggregates, the chiral memory effect, and the selectivity of deprotonation reactions. The examination of mechanistic details has the potential to form the foundation for new chemical transformations with great societal impact, for example, drug synthesis, novel materials for energy applications and less negative environmental impact. The research will develop an important new method designed to extend the use of nuclear magnetic resonance spectroscopy beyond the traditional bounds of structure elucidation/structure determination and into the realm of utilizing this powerful spectroscopic technique to determine size and molecular weight parameters of multicomponent mixtures. Professor Paul G. Williard will help to solve problems of national importance in the realm of energy and fuel production. Broader impacts include international collaborations, working with inner city public high schools, and attracting underrepresented minority undergraduate and graduate students to work in his laboratory, liaising with the Brown University Leadership Alliance Program and the NSF ADVANCE Program.

化学结构、动力学和机制项目支持布朗大学的Paul G. willard教授，他将对重要有机金属试剂的溶液结构和反应性提供更深入的了解，同时进一步扩展扩散有序核磁共振波谱（DOSY）方法的实用性。willard教授描述了DOSY在理解合成化学中广泛使用的有机金属试剂聚集方面的持续发展和应用，并概述了其向其他不相关系统的扩展，展示了该方法的范围和潜力。提出的研究课题包括有机锂试剂中的配体和溶剂交换过程、跨膜扩散、电池应用的膜检查、混合聚集体、手性记忆效应和去质子化反应的选择性。对机械细节的研究有可能形成具有重大社会影响的新化学转化的基础，例如药物合成，能源应用的新材料和较少的负面环境影响。该研究将开发一种重要的新方法，旨在将核磁共振光谱的使用扩展到结构解析/结构测定的传统界限之外，并利用这种强大的光谱技术来确定多组分混合物的大小和分子量参数。Paul G. willard教授将帮助解决能源和燃料生产领域的国家重要问题。更广泛的影响包括国际合作，与市中心公立高中合作，吸引未被充分代表的少数民族本科生和研究生在他的实验室工作，与布朗大学领导联盟计划和国家科学基金会ADVANCE计划联络。