Negative ion mass spectrometry: fundamental studies and applied applications.

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We seek to: (i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous system. (ii) to study the possibility of the formation of biological molecules of life in interstellar regions (iii) to train graduate students to international standards in the chemistry of proteomics.