Negative ion mass spectrometry: fundamental studies and applied applications.

负离子质谱：基础研究和应用。

• 批准号: DP0877356
• 负责人: Prof John Bowie
• 金额: $ 24.22万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877356
• 关键词: Negative; ion; mass; spectrometry; fundamental

We seek to: (i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous system. (ii) to study the possibility of the formation of biological molecules of life in interstellar regions (iii) to train graduate students to international standards in the chemistry of proteomics.

我们力求： (i)建立负离子质谱作为蛋白质测序的分析工具，并探测活性肽Ca 2+钙调蛋白复合物的结构，例如，抑制一氧化氮合酶形成NO。 控制一氧化氮的浓度可能有助于治疗炎症和心脏疾病、中风和中枢神经系统疾病。 (ii)研究在星际区域形成生物分子的可能性 (iii)培养研究生达到蛋白质组学化学的国际标准。