Biologically active peptides and proteins from anurans: the relationship between structure and activity.

无尾动物的生物活性肽和蛋白质：结构与活性之间的关系。

• 批准号: DP0344123
• 负责人: Prof John Bowie
• 金额: $ 24.08万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0344123
• 关键词: Biologically; active; peptides; proteins; anurans

We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide synthase. It would be of national benefit if any of these peptides have applied application, e.g. if we can use the sex pheromone of the cane toad to reduce its population, or if we can produce an anticancer active peptide of clinical applicability.

我们已经鉴定出多肽（来自青蛙和蟾蜍的腺体），其中一些是动物王国中最强大的生物活性化合物之一。本项目的目的是研究信息素、抗癌和抗生素肽以及抑制神经元一氧化氮合酶的肽群的结构与生物活性之间的关系。如果这些多肽中的任何一种得到应用，例如，如果我们可以利用甘蔗蟾蜍的性信息素来减少其数量，或者如果我们可以生产出具有临床应用价值的抗癌活性肽，这将对国家有益。