Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors.

澳大利亚无尾目动物宿主防御肽的结构和活性：抗癌剂、神经肽和 nNOS 抑制剂。

• 批准号: DP0662900
• 负责人: Prof John Bowie
• 金额: $ 25.09万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0662900
• 关键词: Structure; activity; host; defence; peptides

We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.

我们发现了可能具有临床应用的肽。这很重要，因为这些分子可能具有一种或多种以下特性。它们可能具有抗癌作用；它们可以通过增强淋巴细胞的形成来提高免疫系统的有效性； 而且，它们可以通过控制一氧化氮的形成来减少炎症、中风或心脏病。 另一个国家利益是参与该项目的人员接受了肽化学/质谱/核磁共振方面最高国际标准的培训：目前，该领域没有足够的训练有素的科学家来满足需求。