A Workshop for Integrative Additive Biomanufacturing and Tumor Engineering, Bethesda, MD, February 19-20, 2015

PI: Mahler, Gretchen J.提案号：1464736创建高度组织的多细胞肿瘤结构可能会彻底改变肿瘤学和组织工程。增材生物制造、肿瘤学、组织工程、微加工和材料科学的最新进展为在体外创建复杂的血管化3D肿瘤模型提供了新的机会，方法是在高精度机器人的帮助下，逐层精确地打印或沉积材料、癌症及其周围细胞。这些实验室生产的高阶肿瘤组织可作为病理生理研究和药物发现的疾病模型。在这里，PI提议NSF-NIH联合研讨会整合先进生物制造和肿瘤工程。本次研讨会的首要目标是汇集科学领袖来回顾进展，确定将增材制造与肿瘤工程相结合的重大挑战，并最终阐明在生命科学和肿瘤学领域推进物理科学和工程的愿景。增材生物制造、人类基因组编辑、干细胞工程、材料基因组技术、计算和合成生物学以及个性化医疗的出现，为促进肿瘤工程领域的研究、教育、产业增长和创新提供了新的机会。预期通过讲习班可实现下列目标：1)确定表达体内人类肿瘤关键特征的肿瘤模型生物制造中的挑战，2)建立一个社区来分享思想，资源和技术，以解决通过研讨会确定的挑战，3)建立一个工程师与肿瘤学家合作的论坛，反之亦然，4)提高公众对肿瘤工程研究的认识，5)促进肿瘤工程研究和教育计划，对学生进行肿瘤工程研究方面的培训和教育。研讨会将于2015年2月19日至20日在马里兰州贝塞斯达举行。它将包括小组演讲和由主要学者和研究人员进行的深入讨论。小组讨论将由会议主席领导，并由抄写员记录。书记员将负责在讨论的基础上编写一份会议报告。会议报告将进一步扩展为一份讲习班报告，该报告将出版并供公众查阅。研讨会暂定分为“肿瘤芯片”、“多组织集成生理肿瘤模型的3D打印”、“3D打印肿瘤组织的无创表征”和“多尺度肿瘤计算建模”四个环节。虽然最近举办或计划举办的增材制造研讨会和专题讨论会越来越多，但据组织者所知，没有任何研讨会或专题讨论会与拟议的研讨会有重大重叠。预计本次研讨会将启动和促进关于将增材生物制造与肿瘤工程相结合的讨论，并促进工程师，肿瘤学家和生命科学家之间的合作。讲习班的调查结果将以几种不同的方式传播。该报告将被出版，供研究界查阅。来自研讨会的一篇观点论文将发表在同行评议期刊上。研讨会将作为一个开放的论坛，供研究人员和学者相互交流和交换意见。将努力征聘早期职业调查人员和来自代表性不足群体的调查人员参加讲习班。

PI: Mahler, Gretchen J. Proposal Number: 1464736Creation of highly organized multicellular tumor constructs could potentially revolutionize oncology and tissue engineering. The recent advances in additive biomanufacturing, oncology, tissue engineering, microfabrication, and materials science offers new opportunities for creating sophisticated and vascularized 3D tumor models in vitro by printing or depositing materials and cancer and its surrounding cells layer-by-layer precisely with the help of a high-precision robot. These lab-produced high order tumor tissues can be used as disease models for both pathophysiological studies and drug discovery. Here, the PI proposes an NSF-NIH joint Workshop in integrative advanced biomanufacturing and tumor engineering. The overarching goal of this workshop is to bring together scientific leaders to review the progress, to identify grand challenges in integrating additive manufacturing with tumor engineering, and finally to articulate a vision to advance physical sciences and engineering in life sciences and oncology. The emerging of additive biomanufacturing, human genome editing, stem cell engineering, material genome techniques, computational and synthetic biology, and personalized medicine offers new opportunities to spur research, education, industry growth and innovation in tumor engineering. The following objectives are expected to be achieved through the workshop: 1) Identify challenges in biomanufacturing of tumor models that express key characteristics of human tumors in vivo, 2) Develop a community to share ideas, resources, and technologies to address challenges identified through the workshop, 3) Establish a forum for engineers to collaborate with oncologists or vice versa in tumor engineering research, 4) Increase public awareness of tumor engineering research, 5) Promote tumor engineering research and education programs, and train and educate students in tumor engineering research. The workshop will be held in Bethesda, MD, February 19-20, 2015. It will consist of panel presentations and in-depth discussions by leading scholars and researchers. The panel discussion will be led by a session chair and documented by a scribe. The scribe will be responsible for developing a session report based on the discussions. The session report will be further extended into a Workshop Report that will be published and accessible by the public. The workshop will tentatively consist of four sessions including "Tumor-on-A-Chip", "3D Printing of Multiple Tissues Integrated Physiological Tumor Models", "Noninvasive Characterization of 3D Printed Tumor Tissues", and "Multiscale Tumor Computational Modeling". While there have been increasingly more workshops and symposia in additive manufacturing held or planned lately, no workshops or symposia, to the best of organizers' knowledge, have significant overlap with the proposed workshop. It is expected that this workshop will initiate and stimulate the discussion on integrating additive biomanufacturing with tumor engineering and spur collaboration among engineers, oncologists, and life scientists. The findings of the Workshop will be disseminated in several different ways. The report will be published and accessible to the research community. A perspective paper stemmed from the Workshop will be published in a peer-review journal. The workshop will serve as an open forum for researchers and scholars to interact with each other and to exchange ideas. Efforts will be made to recruit early career investigators and investigators from underrepresented groups to participate in the workshop.