A Workshop for Integrative Additive Biomanufacturing and Tumor Engineering, Bethesda, MD, February 19-20, 2015

综合增材生物制造和肿瘤工程研讨会，马里兰州贝塞斯达，2015 年 2 月 19-20 日

• 批准号: 1464736
• 负责人: Gretchen Mahler
• 金额: $ 2.65万
• 依托单位: SUNY at Binghamton
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464736&HistoricalAwards=false
• 关键词: Workshop; Integrative; Additive; Biomanufacturing; Tumor

PI: Mahler, Gretchen J. Proposal Number: 1464736Creation of highly organized multicellular tumor constructs could potentially revolutionize oncology and tissue engineering. The recent advances in additive biomanufacturing, oncology, tissue engineering, microfabrication, and materials science offers new opportunities for creating sophisticated and vascularized 3D tumor models in vitro by printing or depositing materials and cancer and its surrounding cells layer-by-layer precisely with the help of a high-precision robot. These lab-produced high order tumor tissues can be used as disease models for both pathophysiological studies and drug discovery. Here, the PI proposes an NSF-NIH joint Workshop in integrative advanced biomanufacturing and tumor engineering. The overarching goal of this workshop is to bring together scientific leaders to review the progress, to identify grand challenges in integrating additive manufacturing with tumor engineering, and finally to articulate a vision to advance physical sciences and engineering in life sciences and oncology. The emerging of additive biomanufacturing, human genome editing, stem cell engineering, material genome techniques, computational and synthetic biology, and personalized medicine offers new opportunities to spur research, education, industry growth and innovation in tumor engineering. The following objectives are expected to be achieved through the workshop: 1) Identify challenges in biomanufacturing of tumor models that express key characteristics of human tumors in vivo, 2) Develop a community to share ideas, resources, and technologies to address challenges identified through the workshop, 3) Establish a forum for engineers to collaborate with oncologists or vice versa in tumor engineering research, 4) Increase public awareness of tumor engineering research, 5) Promote tumor engineering research and education programs, and train and educate students in tumor engineering research. The workshop will be held in Bethesda, MD, February 19-20, 2015. It will consist of panel presentations and in-depth discussions by leading scholars and researchers. The panel discussion will be led by a session chair and documented by a scribe. The scribe will be responsible for developing a session report based on the discussions. The session report will be further extended into a Workshop Report that will be published and accessible by the public. The workshop will tentatively consist of four sessions including "Tumor-on-A-Chip", "3D Printing of Multiple Tissues Integrated Physiological Tumor Models", "Noninvasive Characterization of 3D Printed Tumor Tissues", and "Multiscale Tumor Computational Modeling". While there have been increasingly more workshops and symposia in additive manufacturing held or planned lately, no workshops or symposia, to the best of organizers' knowledge, have significant overlap with the proposed workshop. It is expected that this workshop will initiate and stimulate the discussion on integrating additive biomanufacturing with tumor engineering and spur collaboration among engineers, oncologists, and life scientists. The findings of the Workshop will be disseminated in several different ways. The report will be published and accessible to the research community. A perspective paper stemmed from the Workshop will be published in a peer-review journal. The workshop will serve as an open forum for researchers and scholars to interact with each other and to exchange ideas. Efforts will be made to recruit early career investigators and investigators from underrepresented groups to participate in the workshop.

PI：Mahler，Gretchen J. 提案编号：1464736创建高度组织化的多细胞肿瘤构建体可能会彻底改变肿瘤学和组织工程学。增材生物制造、肿瘤学、组织工程、微制造和材料科学的最新进展为体外创建复杂和血管化的3D肿瘤模型提供了新的机会，通过在高精度机器人的帮助下精确地逐层打印或沉积材料和癌症及其周围细胞。这些实验室产生的高级肿瘤组织可用作病理生理学研究和药物发现的疾病模型。在这里，PI提议在综合先进生物制造和肿瘤工程方面举办NSF-NIH联合研讨会。本次研讨会的总体目标是汇集科学领导者，审查进展，确定将增材制造与肿瘤工程相结合的重大挑战，并最终阐明推进生命科学和肿瘤学中物理科学和工程的愿景。增材生物制造、人类基因组编辑、干细胞工程、材料基因组技术、计算和合成生物学以及个性化医学的出现为刺激肿瘤工程的研究、教育、产业增长和创新提供了新的机会。预计通过讲习班将实现以下目标：1）确定表达体内人类肿瘤关键特征的肿瘤模型生物制造中的挑战，2）建立一个社区，分享想法，资源和技术，以解决通过研讨会确定的挑战，3）为工程师建立一个论坛，与肿瘤学家合作，反之亦然，在肿瘤工程研究中，4）提高公众对肿瘤工程研究的认识，5）推动肿瘤工程研究和教育计划，培养和教育肿瘤工程研究的学生。研讨会将于2015年2月19日至20日在马里兰州贝塞斯达举行。它将包括小组发言和主要学者和研究人员的深入讨论。小组讨论将由会议主席主持，并由抄写员记录。书记员将负责根据讨论情况编写会议报告。会议报告将进一步扩展为一份讲习班报告，将予以公布，供公众查阅。研讨会将暂定包括四个会议，包括“肿瘤芯片”，“多组织集成生理肿瘤模型的3D打印”，“3D打印肿瘤组织的非侵入性表征”和“多尺度肿瘤计算建模”。虽然最近举办或计划举办的增材制造研讨会和专题讨论会越来越多，但据组织者所知，没有研讨会或专题讨论会与拟议的研讨会有重大重叠。预计本次研讨会将启动并激发关于将增材生物制造与肿瘤工程相结合的讨论，并促进工程师，肿瘤学家和生命科学家之间的合作。讲习班的结果将以几种不同的方式传播。该报告将出版，供研究界查阅。讲习班产生的一份展望文件将发表在一份同行评审期刊上。研讨会将成为研究人员和学者相互交流和交换意见的公开论坛。将努力征聘早期职业调查员和来自任职人数不足群体的调查员参加讲习班。