NSF-BII: Integrative Movement Sciences Institute

NSF-BII：综合运动科学研究所

• 批准号: 2319710
• 负责人: Monica Daley
• 金额: $ 1499.99万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-03-01 至 2030-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2319710&HistoricalAwards=false
• 关键词: NSF; BII; Integrative; Movement; Sciences

Muscle is the active tissue that drives the remarkable agility of animals, enabling feats of speed, endurance, and maneuverability in challenging environments. Understanding how muscle controls movement is essential for animal performance and evolution, and for maintaining human health throughout life. However, muscle function during fast, unsteady motions in complex environments cannot be accurately predicted by current models. Current understanding is limited by isolation among fields, resulting in knowledge gaps between “bottom-up” reductionist approaches that characterize molecules and tissues and “top down” organismal approaches that focus on animal behavior. The Integrative Movement Sciences Institute (IMSI) will bridge these gaps by connecting “bottom-up” and “top-down” approaches to integrate the contributions of mechanical, neural, and sensory systems to movement control. An interdisciplinary team spanning 21 institutions across the country will lead scientific research and training to integrate investigations across structural levels and timescales from molecules to organisms and nanoseconds to generations. The IMSI collaborative network will train scientists in interdisciplinary teamwork, mathematical modeling, data analysis, and open data sharing. IMSI activities will drive innovation in biophysics, physiology, biomechanics, neuroscience, and engineering. Understanding the muscular control of agile movement has wide-reaching applications in bio-technology and the bio-economy through design of movement therapies, rehabilitation programs and mobility assistance devices.Dynamic muscle function forms a critical foundation for an integrative understanding of movement, yet it remains a fundamental challenge to predict muscle force output in fast and unsteady conditions. IMSI will integrate muscular control of movement across scales by critically examining assumptions of current approaches, developing new experiments and models to bridge “bottom-up” and “top-down” perspectives, and constructing a dynamic muscle movement paradigm to transform basic science, clinical and technical applications. Cross-cutting themes include unsteady and perturbed movements, multiscale modeling, and unifying invertebrate, vertebrate, and human studies. Research Cores include: (1) intrinsic muscle dynamics with rheological and X-ray diffraction experiments at nanometer to organismal scales; (2) embedded neuromechanical control to investigate how intrinsic mechanics and sensorimotor networks shape unsteady movement; (3) resilience and versatility to determine how variation in musculoskeletal properties and capacity drive whole-body movement; (4) risk-reward and learning, to determine how experience leads to movement optimization when navigating environmental risks and rewards; and (5) diversity and convergence in motor systems to characterize evolution of dynamic muscle function. IMSI faculty have expertise ranging from molecular biophysics of muscle proteins to animal ecology and human-machine interaction. The team-based science, near-peer mentorship and co-supervisory structure will foster community and provide trainees with a wide mentor network from a range of institutions from primarily undergraduate institutions to research intensive institutions, creating a training pipeline from undergraduates to faculty. IMSI will transform movement sciences by building a new foundation for dynamic muscle function and neuromuscular control of movement that integrates across disciplines, organisms, and structural scales.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

肌肉是驱动动物显着敏捷性的活跃组织，在挑战环境中启用了速度，耐力和可操作性的壮举。了解肌肉控制运动如何对于动物表现和进化以及一生保持人类健康至关重要。但是，当前模型无法准确预测快速，不稳定运动中的肌肉功能。当前的理解受到田间隔离的限制，从而导致“自下而上”的还原主义方法之间的知识差距，这些方法是分子和组织的特征，以及着重于动物行为的“自上而下”有机方法。综合运动学院（IMSI）将通过连接“自下而上”和“自上而下”的方法来弥合这些差距，以整合机械，神经和感觉系统对运动控制的贡献。一支跨越全国21个机构的跨学科团队将领导科学研究和培训，以整合从分子到组织以及纳米秒到几代人的结构层面和时间表的调查。 IMSI协作网络将培训科学家的跨学科团队合作，数学建模，数据分析和开放数据共享。 IMSI活动将推动生物物理学，生理学，生物力学，神经科学和工程的创新。了解敏捷运动的肌肉控制在生物技术中具有广泛的应用，以及通过设计运动疗法，康复计划和流动性辅助设备的设计，在生物经济上进行了广泛的应用。尼方的肌肉功能构成了对运动的综合理解的关键基础，但仍然是对快速和不稳定条件下的肌肉输出的根本挑战。 IMSI将通过严格研究当前方法的假设，开发新的实验和模型来弥合“自下而上”和“自上而下”的观点，并构建动态肌肉运动范式来改变基础科学，临床和技术应用，从而整合跨尺度运动的肌肉控制。横切主题包括不稳定和扰动运动，多尺度建模以及统一的无脊椎动物，脊椎动物和人类研究。研究核心包括：（1）在纳米尺度到有机尺度的流变学和X射线衍射实验的内在肌肉动力学； （2）嵌入的神经力学控制，以研究内在的力学和感觉运动网络如何塑造不稳定运动； （3）确定肌肉骨骼特性和能力的变化如何驱动全身运动的弹性和多功能性； （4）风险回报和学习，以确定经验在驾驶环境风险和奖励时如何导致运动优化； （5）运动系统中的多样性和收敛性，以表征动态肌肉功能的演变。 IMSI教师的专业知识范围从肌肉蛋白的分子生物物理学到动物生态学和人机相互作用。基于团队的科学，近距离的心态和共同讨论的结构将培养社区，并为受训者提供从小学本科机构到研究密集型机构的各种机构的广泛心理网络，创建了从本科到教职员工的培训管道。 IMSI将通过为动态肌肉功能建立新的基础和对运动的神经肌肉控制的新基础来改变运动科学，该基金会跨学科，生物和结构量表整合运动。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子和更广泛影响的审查标准来通过评估来通过评估来支持的。