NSF-BII: Integrative Movement Sciences Institute

NSF-BII：综合运动科学研究所

• 批准号: 2319710
• 负责人: Monica Daley
• 金额: $ 1499.99万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-03-01 至 2030-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2319710&HistoricalAwards=false
• 关键词: NSF; BII; Integrative; Movement; Sciences

Muscle is the active tissue that drives the remarkable agility of animals, enabling feats of speed, endurance, and maneuverability in challenging environments. Understanding how muscle controls movement is essential for animal performance and evolution, and for maintaining human health throughout life. However, muscle function during fast, unsteady motions in complex environments cannot be accurately predicted by current models. Current understanding is limited by isolation among fields, resulting in knowledge gaps between “bottom-up” reductionist approaches that characterize molecules and tissues and “top down” organismal approaches that focus on animal behavior. The Integrative Movement Sciences Institute (IMSI) will bridge these gaps by connecting “bottom-up” and “top-down” approaches to integrate the contributions of mechanical, neural, and sensory systems to movement control. An interdisciplinary team spanning 21 institutions across the country will lead scientific research and training to integrate investigations across structural levels and timescales from molecules to organisms and nanoseconds to generations. The IMSI collaborative network will train scientists in interdisciplinary teamwork, mathematical modeling, data analysis, and open data sharing. IMSI activities will drive innovation in biophysics, physiology, biomechanics, neuroscience, and engineering. Understanding the muscular control of agile movement has wide-reaching applications in bio-technology and the bio-economy through design of movement therapies, rehabilitation programs and mobility assistance devices.Dynamic muscle function forms a critical foundation for an integrative understanding of movement, yet it remains a fundamental challenge to predict muscle force output in fast and unsteady conditions. IMSI will integrate muscular control of movement across scales by critically examining assumptions of current approaches, developing new experiments and models to bridge “bottom-up” and “top-down” perspectives, and constructing a dynamic muscle movement paradigm to transform basic science, clinical and technical applications. Cross-cutting themes include unsteady and perturbed movements, multiscale modeling, and unifying invertebrate, vertebrate, and human studies. Research Cores include: (1) intrinsic muscle dynamics with rheological and X-ray diffraction experiments at nanometer to organismal scales; (2) embedded neuromechanical control to investigate how intrinsic mechanics and sensorimotor networks shape unsteady movement; (3) resilience and versatility to determine how variation in musculoskeletal properties and capacity drive whole-body movement; (4) risk-reward and learning, to determine how experience leads to movement optimization when navigating environmental risks and rewards; and (5) diversity and convergence in motor systems to characterize evolution of dynamic muscle function. IMSI faculty have expertise ranging from molecular biophysics of muscle proteins to animal ecology and human-machine interaction. The team-based science, near-peer mentorship and co-supervisory structure will foster community and provide trainees with a wide mentor network from a range of institutions from primarily undergraduate institutions to research intensive institutions, creating a training pipeline from undergraduates to faculty. IMSI will transform movement sciences by building a new foundation for dynamic muscle function and neuromuscular control of movement that integrates across disciplines, organisms, and structural scales.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

肌肉是一种活跃的组织，它驱动着动物非凡的敏捷性，使其在具有挑战性的环境中具有速度，耐力和机动性。了解肌肉如何控制运动对于动物的表现和进化以及维持人类一生的健康至关重要。然而，目前的模型无法准确预测复杂环境中快速、不稳定运动期间的肌肉功能。 目前的理解是有限的领域之间的隔离，导致知识差距之间的“自下而上”的还原论的方法，表征分子和组织和“自上而下”的有机体的方法，专注于动物的行为。综合运动科学研究所（IMSI）将通过连接“自下而上”和“自上而下”的方法来弥合这些差距，以整合机械，神经和感觉系统对运动控制的贡献。一个跨越全国21个机构的跨学科团队将领导科学研究和培训，以整合从分子到生物体，从纳秒到几代人的结构层次和时间尺度的调查。IMSI协作网络将培训科学家进行跨学科团队合作、数学建模、数据分析和开放数据共享。IMSI活动将推动生物物理学、生理学、生物力学、神经科学和工程学领域的创新。了解敏捷运动的肌肉控制在生物技术和生物经济中有着广泛的应用，通过设计运动疗法，康复计划和移动辅助设备，动态肌肉功能形成了一个关键的基础，运动的综合理解，但它仍然是一个根本性的挑战，预测肌肉力量输出在快速和不稳定的条件。IMSI将通过批判性地检查当前方法的假设，开发新的实验和模型来弥合“自下而上”和“自上而下”的观点，并构建动态肌肉运动范式来改变基础科学，临床和技术应用，从而整合跨尺度的肌肉运动控制。交叉主题包括不稳定和扰动运动，多尺度建模，以及统一的无脊椎动物，脊椎动物和人类研究。研究核心包括：（1）内在肌肉动力学与纳米至生物体尺度的流变学和X射线衍射实验;（2）嵌入式神经机械控制，以研究内在力学和感觉运动网络如何形成不稳定运动;（3）弹性和多功能性，以确定肌肉骨骼特性和能力的变化如何驱动全身运动;（4）风险-回报和学习，以确定在导航环境风险和回报时经验如何导致运动优化;以及（5）运动系统的多样性和收敛性，以表征动态肌肉功能的进化。IMSI的教师拥有从肌肉蛋白的分子生物物理学到动物生态学和人机交互的专业知识。以团队为基础的科学，近同行的指导和共同监督结构将促进社区，并为学员提供广泛的导师网络，从主要的本科院校到研究密集型机构，创造了从本科生到教师的培训管道。IMSI将通过为动态肌肉功能和运动的神经肌肉控制建立一个新的基础来改变运动科学，该基础整合了学科，生物体和结构尺度。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。