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SusChEM: Oxidative Methods for C-C, C-N, and C-O Bond Formation

SusChEM：C-C、C-N 和 C-O 键形成的氧化方法

基本信息

批准号：
1464778
负责人：
Marisa Kozlowski
金额：
$ 48.6万
依托单位：
University of Pennsylvania
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464778&HistoricalAwards=false
关键词：
SusChEM Oxidative Methods Bond Formation

项目摘要

With this award, the Chemical Synthesis Program of the Chemistry Division is supporting Professor Marisa C. Kozlowski of the Department of Chemistry at the University of Pennsylvania to explore the development of methods for the formation of C-C, C-N, and C-O bonds by oxidative coupling reactions. The formation of such bonds by facile oxidative transformations is a well-recognized process in biological systems. Such routes often introduce functionality at non-functionalized centers, thereby eliminating the need for complex pre-functionalized starting materials. To achieve these goals, individual reaction steps will be studied using stoichiometric conditions in order to understand the principles governing novel reactivity and selectivity. The chemistry studied will contribute to environmentally benign methods for chemical synthesis as oxygen is used as the terminal oxidizing agent in combination with less toxic and less expensive base metals. Successful development of the methodology will have a broad impact as there is an important need for synthetic methods in areas ranging from the pharmaceutical, chemical, materials science, and agricultural industries to basic biological and chemical research endeavors. The broader impacts involve training undergraduate students, graduate students and postdoctoral researchers. Broadening the participation of underrepresented populations in chemistry research is a particular focus with support for the newly established Association for Cultural Diversity (ACDC) in Chemistry at Penn. This organization is a chapter of the National Consortium for Diversity in Science and Engineering with the mission of promoting diversity of underrepresented minorities in STEM fields at Penn and surrounding universities.

该奖项由化学系化学合成计划支持宾夕法尼亚大学化学系Marisa C.Kozlowski教授探索通过氧化偶联反应形成C-C、C-N和C-O键的方法。在生物系统中，通过容易的氧化转化形成这样的键是一个公认的过程。这样的路线通常在非功能化中心引入功能，从而消除了对复杂的预功能化起始材料的需要。为了实现这些目标，将使用化学计量条件研究单个反应步骤，以了解支配新的反应性和选择性的原理。所研究的化学将有助于环境友好的化学合成方法，因为氧被用作终端氧化剂，与毒性较低、价格较低的贱金属相结合。方法学的成功发展将产生广泛的影响，因为从制药、化学、材料科学和农业到基础生物和化学研究领域，对合成方法的重要需求。更广泛的影响包括培养本科生、研究生和博士后研究人员。在宾夕法尼亚大学新成立的文化多样性协会(ACDC)的支持下，扩大未被充分代表的人群对化学研究的参与是一个特别的重点。该组织是国家科学和工程多样性联合会的一个分会，其使命是促进宾夕法尼亚大学和周围大学STEM领域中代表性不足的少数群体的多样性。