Oxidative Methods for C-C and C-N Bond Formation

形成 C-C 和 C-N 键的氧化方法

• 批准号: 0616885
• 负责人: Marisa Kozlowski
• 金额: --
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616885&HistoricalAwards=false
• 关键词: Oxidative; Methods; Bond; Formation

This project will continue work on the development of methods for the formation of C-C and C-N bonds by facile oxidative reactions. While dimerizations of phenol derivatives are well-recognized processes, little progress has been made in the development of catalytic asymmetric methods for the formation of chiral biaryls via oxidative dimerization. Studies to further elucidate the mechanism of this complex catalytic cycle will be undertaken. Combinatorial type screening of ligands with transition metal oxidants will be carried out to identify new useful catalysts. Hypothesis driven studies of new oxidative reactions will be also performed. With this award, the Organic and Macromolecular Chemistry Program and the Office of Multidisciplinary Activities are supporting the research of Professor Marisa C. Kozlowski of the Department of Chemistry at University of Pennsylvania. Professor Kozlowski's research efforts revolve around the development of facile oxidative methods for the formation of C-C and C-N bonds. Such chemistry will contribute to environmentally benign methods for chemical synthesis as oxygen is used as the terminal oxidizing agent. Successful development of the methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.

该项目将继续致力于开发通过简单氧化反应形成C-C和C-N键的方法。 虽然苯酚衍生物的二聚反应是公认的方法，但在通过氧化二聚反应形成手性联芳基的催化不对称方法的开发方面几乎没有进展。 将开展研究，进一步阐明这一复杂催化循环的机制。 将进行具有过渡金属氧化剂的配体的组合类型筛选以鉴定新的有用催化剂。 还将进行新氧化反应的假设驱动研究。 有了这个奖项，有机和高分子化学计划和多学科活动办公室支持教授玛丽莎C。宾夕法尼亚大学化学系的Kozlowski说。 Kozlowski教授的研究工作围绕着开发用于形成C-C和C-N键的简易氧化方法。 这种化学将有助于环境友好的化学合成方法，因为氧气被用作终端氧化剂。 该方法的成功开发将对制药和农业工业的合成产生影响。