CAREER: Asymmetric Oxidative Methods for C-C Bond Formation

职业生涯：形成 C-C 键的不对称氧化方法

• 批准号: 0094187
• 负责人: Marisa Kozlowski
• 金额: $ 48万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2007-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0094187&HistoricalAwards=false
• 关键词: CAREER; Asymmetric; Oxidative; Methods; Bond

The proposed research focuses on asymmetric biaryl oxidative coupling reactions. Combinatorial type screening of ligands with transition metal oxidants will be undertaken to identify new, useful catalysts. A variety of substrates and issues of chemo- and regioselectivity will be examined. The educational component of this plan introduces graphics and internet examples into the undergraduate organic chemistry course as well as computional chemistry using CSC Chem3D Ultra. Graduate and undergraduate students in the principal investigator's research group also receive training in computional chemistry.With the CAREER award, the Organic Synthesis Program is supporting the research and educational activities of Professor Marisa Kozlowski of the Department of Chemistry at the University of Pennsylvania. Professor Kozlowski's research applies concepts from computional and organic chemistry to design and synthesize new molecules which are useful as ligands for new catalysts or as building blocks for certain natural products. The educational portion of the plan is directed towards using computional chemistry methods as a teaching tool at both the undergraduate and graduate level.

本论文主要研究不对称联芳基氧化偶联反应。 将进行配体与过渡金属氧化剂的组合类型筛选以鉴定新的有用的催化剂。 各种基板和问题的化学和区域选择性将被检查。 该计划的教育部分将图形和互联网示例引入本科有机化学课程以及使用CSC Chem3D Ultra的计算化学。 主要研究者研究小组的研究生和本科生也接受计算化学方面的培训。凭借CAREER奖，有机合成计划支持宾夕法尼亚大学化学系Marisa Kozlowski教授的研究和教育活动。 Kozlowski教授的研究应用了计算化学和有机化学的概念来设计和合成新的分子，这些分子可用作新催化剂的配体或某些天然产物的构建模块。 该计划的教育部分是针对使用计算化学方法作为教学工具，在本科和研究生水平。