CAREER: Asymmetric Oxidative Methods for C-C Bond Formation

建议的研究重点是不对称联芳基氧化偶联反应。将对具有过渡金属氧化剂的配体进行组合类型筛选，以确定新的、有用的催化剂。将研究各种底物以及化学和区域选择性问题。该计划的教育部分将图形和互联网示例引入本科有机化学课程，以及使用CSC Chem3D Ultra的计算化学。首席研究员研究组的研究生和本科生也接受了计算化学方面的培训。通过获得职业奖，有机合成项目正在支持宾夕法尼亚大学化学系玛丽莎·科兹洛夫斯基教授的研究和教育活动。科兹洛夫斯基教授的研究应用计算和有机化学的概念来设计和合成新分子，这些分子可用作新催化剂的配体或某些天然产品的基础。该计划的教育部分旨在使用计算化学方法作为本科生和研究生的教学工具。

The proposed research focuses on asymmetric biaryl oxidative coupling reactions. Combinatorial type screening of ligands with transition metal oxidants will be undertaken to identify new, useful catalysts. A variety of substrates and issues of chemo- and regioselectivity will be examined. The educational component of this plan introduces graphics and internet examples into the undergraduate organic chemistry course as well as computional chemistry using CSC Chem3D Ultra. Graduate and undergraduate students in the principal investigator's research group also receive training in computional chemistry.With the CAREER award, the Organic Synthesis Program is supporting the research and educational activities of Professor Marisa Kozlowski of the Department of Chemistry at the University of Pennsylvania. Professor Kozlowski's research applies concepts from computional and organic chemistry to design and synthesize new molecules which are useful as ligands for new catalysts or as building blocks for certain natural products. The educational portion of the plan is directed towards using computional chemistry methods as a teaching tool at both the undergraduate and graduate level.