CAS: Investigation of Oxidative Construction/Deconstruction

CAS：氧化构建/解构的研究

• 批准号: 2400215
• 负责人: Marisa Kozlowski
• 金额: $ 57.5万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2400215&HistoricalAwards=false
• 关键词: CAS; Investigation; Oxidative; Construction; Deconstruction

With the support of the Chemical Synthesis Program in the Division of Chemistry, Professor Kozlowski of the University of Pennsylvania is developing methodology to connect molecules by forming new carbon-carbon bonds, to convert polymer waste into value-added materials, and to generate molecules to study atmospheric oxidation events. These activities are helping to: (i) improve synthetic technology that will result in more efficient and sustainable processes to generate advanced materials, (ii) optimize catalysts that lead to selective reactions, and (iii) find productive uses for polymer waste streams. The link among these projects is that the types of reactions being studied are oxidations, which reduce the number of carbon-hydrogen bonds in a molecule and replace them with more valuable carbon-carbon or carbon-oxygen bonds. More broadly, this program is working to improve chemistry instruction by employing methodology that focuses on student growth instead of high stakes tests. Professor Kozlowski is also actively involved in developing professional support systems for increasing diversity in science, engineering and mathematics disciplines.The development of novel oxidative synthetic methods whose goals include the design of environmentally benign chemical processes is important. Professor Kozlowski and her research team are investigating new oxidative methods for complex molecule synthesis by optimizing light-driven reactions for the preparation of polyaromatic hydrocarbons and the valorization of chemical waste. The Kozlowski team is also studying solid catalysts for alkylarene cross-coupling reactions. Additional efforts are focused on studying the rates that atmospheric oxidation intermediates decompose. These studies are contributing to the goal of designing sustainable methods by: (i) engineering reactions at non-functionalized centers, thereby eliminating the need for complex pre-functionalized starting materials; (ii) using oxygen as the terminal oxidizing agent, (iii) using more abundant and less expensive base metals, and (iv) converting waste materials to useful chemicals. In a complementary research area, the fate of volatile organic compounds in the atmosphere is being investigated. These efforts are critical for modeling both pollution and climate processes. Through these activities, Professor Kozlowski and her research team are working at the nexus of organic, computational, atmospheric, and materials chemistry toward new sustainable chemistry solutions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学合成计划的支持下，宾夕法尼亚大学的Kozlowski教授正在开发通过形成新的碳-碳键连接分子的方法，将聚合物废物转化为增值材料，并产生分子来研究大气氧化事件。这些活动有助于：（一）改进合成技术，从而提高生产先进材料的效率和可持续性;（二）优化催化剂，从而实现选择性反应;（三）为聚合物废物流找到生产用途。这些项目之间的联系是，正在研究的反应类型是氧化反应，它减少了分子中碳氢键的数量，并用更有价值的碳碳或碳氧键取代它们。更广泛地说，该计划正在努力通过采用注重学生成长而不是高风险测试的方法来改善化学教学。Kozlowski教授还积极参与开发专业支持系统，以增加科学，工程和数学学科的多样性。开发新的氧化合成方法，其目标包括设计环境友好的化学过程是重要的。Kozlowski教授和她的研究团队正在研究复杂分子合成的新氧化方法，通过优化光驱动反应来制备多环芳烃和化学废物。 Kozlowski团队还在研究用于烷基芳烃交叉偶联反应的固体催化剂。其他工作的重点是研究大气氧化中间产物的分解速率。这些研究有助于通过以下方式实现设计可持续方法的目标：（i）在非官能化中心进行工程反应，从而消除对复杂的预官能化起始材料的需求;（ii）使用氧气作为末端氧化剂;（iii）使用更丰富且更便宜的贱金属;以及（iv）将废料转化为有用的化学品。在一个补充研究领域，正在调查挥发性有机化合物在大气中的归宿。这些努力对于模拟污染和气候过程至关重要。通过这些活动，Kozlowski教授和她的研究团队致力于有机化学、计算化学、大气化学和材料化学的联系，以实现新的可持续化学解决方案。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。