SusChem: Innovation Inspired by Amides: Oxidative Ni-catalysis, Cascade Acylations, and Green Peptide Synthesis

SusChem：受酰胺启发的创新：氧化镍催化、级联酰化和绿色肽合成

• 批准号: 1465263
• 负责人: Vy Dong
• 金额: $ 56万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1465263&HistoricalAwards=false
• 关键词: SusChem; Innovation; Inspired; Amides; Oxidative

The Chemical Synthesis and the Catalysis Programs are co-funding a project by Professor Vy Maria Dong from the University of California at Irvine that aims to identify environmentally benign and efficient methods for synthetic chemistry. Professor Dong's research team is focused on the study of inexpensive and earth abundant metals as constituents in catalysts that allow the formation of common linkages in organic molecules. The project provides practical methods for making molecules by minimizing both costs and waste. An outreach program created by Professor Dong focuses on a conference/workshop to support and promote women in the field of organic synthesis. This meeting provides an avenue for graduate students in Southern California to network, collaborate, and exchange ideas.Professor Dong's research project impacts the synthesis of a wide-range of molecules that contain the commonly occurring ester and amide linkage. The use of base-metal catalysts contributes to the nations need for more efficient and sustainable chemistry. The pursuit of oxidative Ni-catalysis is an unexplored mode of reactivity that enables the conversion of aldehydes into esters, amides, and ketones. This platform provides a unique avenue for enantioselective reductions and regioselective acylations. The stereoselective acylations described have the potential to impact synthetic routes to a vast number of natural products that bear chiral ester and acetamido ester motifs. Studies on the mechanism of this catalytic process impact related cooperative catalytic methodology. The final aim pursues an environmentally benign peptide synthesis as a new approach to a central problem in synthesis with widespread applications.

化学合成和催化计划共同资助了一个由加州大学欧文分校的Vy Maria Dong教授发起的项目，该项目旨在确定环境友好和有效的合成化学方法。董教授的研究团队专注于研究廉价和地球丰富的金属作为催化剂的成分，使有机分子中形成共同的连接。该项目提供了通过最小化成本和浪费来制造分子的实用方法。董教授创建的一个推广计划侧重于一个会议/研讨会，以支持和促进妇女在有机合成领域。本次会议为南加州的研究生提供了一个网络，合作和交流思想的途径。董教授的研究项目影响了广泛的分子的合成，这些分子含有常见的酯和酰胺键。贱金属催化剂的使用有助于各国对更高效和可持续化学的需求。追求氧化镍催化是一种未开发的反应模式，使醛转化为酯，酰胺和酮。该平台为对映选择性还原和区域选择性酰化提供了独特的途径。所描述的立体选择性酰化具有潜在的影响合成路线，以大量的天然产物，承载手性酯和乙酰氨基酯基序。该催化过程机理的研究对相关的协同催化方法学有重要影响。最终的目标是追求一个环境友好的肽合成作为一个新的方法，在合成中的一个中心问题，具有广泛的应用。