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Fundamental Properties of Saloplastic Polyelectrolyte Complexes

药塑性聚电解质复合物的基本性质

基本信息

批准号：
1506824
负责人：
Joseph Schlenoff
金额：
$ 45.3万
依托单位：
Florida State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1506824&HistoricalAwards=false
关键词：
Fundamental Properties Saloplastic Polyelectrolyte Complexes

项目摘要

NON-TECHNICAL:Polyelectrolytes are water-soluble, charged polymers used in products ranging from shampoos to water purification treatments. If solutions of polyelectrolytes with opposite charges are mixed they precipitate into complexes that are biocompatible, rugged, elastic blends of the individual polymers. These complexes have potential medical applications in extended drug delivery and replacement for cartilage. They are also useful as membranes for water purification and desalination. Although their synthesis is straightforward, it has been impossible to process them into useful forms using heat softening, as is used for the more familiar "thermoplastics". This project will explore novel, versatile methods for softening and processing polyelectrolyte complexes using salt water instead of heat. Softening by adding salt, termed "saloplasticity", is a new technique that lowers energy consumption for polymer processing. Because it is performed with no volatile organic solvents it is also environmentally friendly. Several fundamental questions will be explored in this project: how do blends of different polymers respond to different salts? How is elasticity, essential for mimicking the properties of cartilage, controlled by salt? How can additional strength be built into saloplastics so they will last when used as replacements for intervertebral discs? At the same time these fundamental materials properties questions are explored, the project will support and promote international collaborations with the University of Strasbourg, France. Among the educational aspects of this project will also be a collaboration between the College of Business and the Department of Chemistry at Florida State University wherein Entrepreneurship and Chemistry students team up to write commercialization plans for technology developed by this and other projects. TECHNICAL:Polyelectrolytes are water-soluble, charged polymers used in products ranging from shampoos to water purification treatments. If solutions of polyelectrolytes with opposite charges are mixed they precipitate into complexes that are biocompatible, rugged, viscoelastic blends of the individual polymers. Unlike traditional thermoplastics, polyelectrolyte complexes, PECs, cannot be processed when dry by heat softening. Instead, they may be plasticized with salt water. Increasing salt concentration progressively breaks the ionic pairing between polyelectrolytes. This "saloplasticity" is used along with heating to control the viscoelasticity of PECs. The overarching goal of this project is to probe the fundamental ways salt and heat are related to the properties of saloplastics. In the first of four subtopics, the glass transition, or softening temperature, of different pairs of polyelectrolytes with different strengths of interaction will be probed. The second part will look at the processing response of blends versus copolymers having the same composition. The next subtopic will attempt to answer fundamental questions about the role of molecular weight in saloplastic viscoelasticity. Finally, additional chemical crosslinks will be built into bulk saloplastics to stabilize the material for long-term use in biomedical applications such as artificial cartilage.

非技术：聚电解质是水溶性的带电聚合物，用于从洗发水到水净化处理等产品。如果将带相反电荷的聚电解质溶液混合在一起，它们就会沉淀成具有生物相容性的、坚固的、有弹性的单个聚合物混合物。这些复合物在延长药物递送和软骨替代方面具有潜在的医学应用。它们也可用作水净化和脱盐的膜。虽然它们的合成很简单，但不可能像我们更熟悉的“热塑性塑料”那样，用热软化的方法将它们加工成有用的形式。该项目将探索用盐水代替热来软化和加工多电解质复合物的新颖、通用的方法。通过添加盐进行软化，被称为“盐塑性”，是一种降低聚合物加工能耗的新技术。因为它是在没有挥发性有机溶剂的情况下进行的，所以它也是环保的。本项目将探讨几个基本问题：不同聚合物的混合物对不同盐的反应如何？对于模拟软骨的特性至关重要的弹性是如何被盐控制的？如何将额外的强度建立在塑料制品中，使它们在用作椎间盘替代品时能够持续使用？在探索这些基本材料特性问题的同时，该项目将支持和促进与法国斯特拉斯堡大学的国际合作。这个项目的教育方面还包括商学院和佛罗里达州立大学化学系之间的合作，其中创业学和化学系的学生将组队为这个项目和其他项目开发的技术撰写商业化计划。技术：聚电解质是一种水溶性的带电聚合物，用于从洗发水到水净化处理等产品中。如果将带相反电荷的聚电解质溶液混合，它们会沉淀成具有生物相容性、坚固耐用、粘弹性的单个聚合物混合物的络合物。与传统的热塑性塑料不同，聚电解质复合物（PECs）在干燥时不能通过热软化处理。相反，它们可能会被盐水塑化。盐浓度的增加逐渐破坏了聚电解质之间的离子配对。这种“盐塑性”与加热一起用于控制PECs的粘弹性。该项目的总体目标是探索盐和热与盐塑料性能相关的基本方式。在四个子主题中的第一个，将探讨具有不同相互作用强度的不同对聚电解质的玻璃化转变或软化温度。第二部分将研究具有相同组成的共混物与共聚物的加工响应。下一个小主题将试图回答有关分子量在盐塑性粘弹性中的作用的基本问题。最后，额外的化学交联将被构建到大块的盐塑料中，以稳定材料在生物医学应用中的长期使用，如人造软骨。