Peptide Derivatized Poly(ester urea)s for Regenerative Medicine

非技术性：该奖项由阿克伦大学材料研究部的生物材料项目授予，旨在发现将生物活性肽可控地连接到用于再生医学应用的新型聚合物支架上的系统方法。该奖项也由CBET/ENG的生物医学工程项目共同资助。如果成功，这项工作将优化肽浓度，增强细胞增殖并加速干细胞分化。 这些知识将有助于指导未来肽功能化聚合物表面，支架和水凝胶的合理设计，用于更广泛的组织工程界。生物测量将推动先进的生物活性和仿生材料的设计，用于合成材料接触生物系统的许多应用。 研究小组参与了该项目的教育培训部分。这项工作将提供先进的，多学科的培训，本科生和研究生，整形外科住院医生，以及高中学生在分子和细胞生物学，化学和聚合物科学领域。 这项研究的成果正被直接纳入贝克尔教授的研究生课程和本科课程。 来自阿克伦大学的本科生和参加本科生研究经验（REU）计划的暑期实习生将广泛参与。研究团队的推广活动包括指导，并为当地高中的学生提供教育和研究经验。技术：该奖项由材料研究部的生物材料项目和CBET/ENG的生物医学工程项目授予阿克伦大学，旨在发现一种系统的方法，用于可控地将多种生物活性肽连接到新型聚（酯脲）支架3D打印后用于再生医学应用。 生物材料界清楚地认识到，肽和生长因子的分子呈现和空间分布可以显着影响细胞行为的许多重要方面。该奖项旨在将先前发现的GRGDS和BMP-2肽浓度转化为二维薄膜和三维打印支架中的可降解聚酯脲结构。 该项目将影响生物材料的几个领域，包括（1）开发3D打印后具有生物活性肽的可降解聚合物支架功能化的新方法，（2）表征这些肽表面浓度的新方法，以及（3）鉴定影响hMSC细胞增殖，谱系承诺和分化的协同肽浓度。 该项目为学生（本科生和研究生）和医学住院医师提供了多种教育培训机会，包括先进的聚合物科学，最先进的化学功能化和先进的3D支架制造的预防性相关策略。 这些技能对于旨在将3D打印支架转移到主流设备和再生医学应用中的公共和私人实体至关重要。

Nontechnical: This award by the Biomaterials program in the Division of Materials Research to the University of Akron aims at discovering systematic method for controllably tethering bioactive peptides to novel polymer scaffolds for use in regenerative medicine applications. This award is also co-funded by the Biomedical Engineering program in CBET/ENG. If successful, this work will optimize peptide concentrations that enhance cell proliferation and accelerate stem cell differentiation. This knowledge would help guide the rational design of future peptide-functionalized polymer surfaces, scaffolds and hydrogels used by the wider tissue engineering community. The biological measurements will drive the design of advanced bioactive and biomimetic materials for use in many applications where synthetic materials contact biological systems. The research team is involved in the educational training components of the project. The effort will provide advanced, multidisciplinary training to undergraduate and graduate students, orthopedic surgery residents, and high school students in areas of molecular and cell biology, chemistry and polymer science. The outcomes from the research are being directly incorporated into graduate level and undergraduate courses being taught by Professor Becker. Undergraduate students from the University of Akron, and summer interns enrolled in the research experiences for undergraduates (REU) program will participate extensively. The research team's outreach activities include mentoring and provide educational and research experience for students from local high schools.Technical: This award by the Biomaterials program in the Division of Materials Research and the Biomedical Engineering program in CBET/ENG to the University of Akron aims at discovering a systematic method for controllably tethering multiple bioactive peptides to novel poly(ester urea) scaffolds post-3D printing for use in regenerative medicine applications. The biomaterials community clearly understands that the molecular presentation and spatial distribution of peptides and growth factors can dramatically influence many important aspects of cell behavior. This award aims to translate previously discovered GRGDS and BMP-2 peptide concentrations to translationally-relevant degradable poly(ester urea) constructs in two-dimensional thin films and three-dimensional printed scaffolds. The project will impact several fields of biomaterials including (1) developing new methods for functionalization of degradable polymer scaffolds with bioactive peptides post 3D printing and (2) new methods for characterizing surface concentrations of these peptides and (3) identification of synergistic peptide concentrations that influence hMSC cell proliferation, lineage commitment, and differentiation. The project offers multiple opportunities for the educational training of students (both undergraduate and graduate) and medical residents in advanced polymer science, state of the art chemical functionalization and translationally-relevant strategies for advanced manufacturing of 3D scaffolds. These skills will be critical to public and private entities aiming to move 3D printed scaffolds into mainstream device and regenerative medicine applications.