GOALI: Collaborative Research: Next generation 2D-LC with greatly improved quantitative performance: Innovations in hardware, software, and methodology
目标:协作研究:定量性能大幅提高的下一代 2D-LC:硬件、软件和方法方面的创新
基本信息
- 批准号:1508159
- 负责人:
- 金额:$ 21.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this project funded by the Chemical Measurement and Imaging program of the Chemistry Division, Professors Dwight Stoll of Gustavus Adolphus College and Sarah Rutan of Virginia Commonwealth University are studying fundamental aspects of the quantitative performance of two-dimensional liquid chromatography (2D-LC). This project uses the Grant Opportunities for Academic Liaison with Industry (GOALI) program of the NSF to form an industry alliance with a leading liquid chromatography company, Agilent Tecnhologies. 2D-LC is an analytical methodology used for separation of inherently complex materials including urine, blood, urban wastewater, and the products of chemical and biological synthesis. This academic/industrial collaboration among Gustavus Adolphus College, Virginia Commonwealth University and Agilent Technologies is expected to lead to a deeper fundamental understanding of these limitations and support the development of novel technologies to improve the quantitative performance of 2D-LC.The broader impacts of the work include: wider application of 2D-LC as a high resolution separation technique across the life sciences and chemical industries; engagement of students at the high school, undergraduate, and graduate levels in cutting-edge research; and development of simulations that will facilitate more efficient and deeper learning about critical concepts in liquid chromatography.The separation power of 2D-LC is well suited to better understand complex samples in fields ranging from medicine and pharmaceutical development to environmental chemistry. However, state-of-the-art 2D-LC currently suffers from poorer sensitivity and precision compared to more conventional methods, and this limits its scope of application. This project will leverage the strengths of the collaboration partners to address the limitations in quantitative performance of 2D-LC through a combination of complementary strategies. Simulations will be developed to better understand the underlying fundamental limitations of coupling the two dimensions in 2D-LC, novel valve technology will be developed and its performance characterized experimentally, and computer-based data analysis methods will be developed that enable better utilization of the multi-dimensional structure of data produced by 2D-LC methods. It is expected that the detection limits of 2D-LC will be improved at least five-fold, and that the quantitative precision will be improved so that it is competitive with conventional liquid chromatography.
在这个由化学部化学测量和成像计划资助的项目中,Gustavus Adolphus学院的德怀特斯托尔教授和弗吉尼亚联邦大学的莎拉·鲁坦教授正在研究二维液相色谱(2D-LC)定量性能的基本方面。该项目利用美国国家科学基金会(NSF)的学术联络与工业(GOALI)计划的赠款机会,与领先的液相色谱公司安捷伦科技公司形成行业联盟。2D-LC是一种用于分离固有复杂材料的分析方法,包括尿液,血液,城市废水以及化学和生物合成产物。Gustavus Adolphus College、Virginia Commonwealth University和Agilent Technologies之间的这种学术/工业合作预计将导致对这些限制的更深入的基本理解,并支持新技术的开发以改善2D-LC的定量性能。这项工作的更广泛影响包括:2D-LC作为高分辨率分离技术在生命科学和化学工业中的更广泛应用; 2D-LC的分离能力非常适合更好地理解从医学和制药开发到环境化学等领域的复杂样品。2D-LC的分离能力有助于更好地理解从医学和制药开发到环境化学等领域的复杂样品。然而,与更常规的方法相比,目前最先进的2D-LC具有较差的灵敏度和精度,这限制了其应用范围。 该项目将利用合作伙伴的优势,通过互补策略的组合来解决2D-LC定量性能的局限性。 模拟将被开发,以更好地了解耦合的二维二维LC的基本限制,新的阀门技术将被开发,其性能的实验表征,和基于计算机的数据分析方法将被开发,使更好地利用二维LC方法产生的数据的多维结构。预计2D-LC的检测限将提高至少五倍,并且定量精度将提高,从而与常规液相色谱竞争。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dwight Stoll其他文献
Enhancing LC×LC separations through multi-task Bayesian optimization.
通过多任务贝叶斯优化增强 LC×LC 分离。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:4.1
- 作者:
Jim Boelrijk;S. Molenaar;Tijmen S Bos;T. Dahlseid;Bernd Ensing;Dwight Stoll;Patrick Forré;B. Pirok - 通讯作者:
B. Pirok
The Gradient Delay Volume, Part III: Practice – Effects on Throughput
梯度延迟量,第三部分:实践 - 对吞吐量的影响
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Dwight Stoll - 通讯作者:
Dwight Stoll
Changes in the cis-trans isomer selectivity of a reversed-phase liquid chromatography column during use with acidic mobile phase conditions
反相液相色谱柱在酸性流动相条件下使用时顺反异构体选择性的变化
- DOI:
10.1016/j.chroma.2023.464371 - 发表时间:
2023-10-11 - 期刊:
- 影响因子:4.000
- 作者:
Tina Dahlseid;Alexandru Florea;Grace Schulte;Kathryn Cash;Xuejun Xu;Peter Tattersall;Qinggang Wang;Dwight Stoll - 通讯作者:
Dwight Stoll
The Gradient Delay Volume, Part II: Practice – Effects on Method Transfer
梯度延迟体积,第二部分:实践 - 对方法转移的影响
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Dwight Stoll - 通讯作者:
Dwight Stoll
Improving the Accuracy of Predictive 2D-LC Optimization Strategies: Incorporation of Simulated Elution Profiles to Account for Injection Band Broadening in Online Comprehensive Two-Dimensional Liquid Chromatography
提高预测 2D-LC 优化策略的准确性:结合模拟洗脱曲线来解决在线综合二维液相色谱中的进样谱带展宽问题
- DOI:
10.1021/acs.analchem.4c00491 - 发表时间:
2024 - 期刊:
- 影响因子:7.4
- 作者:
Magriet Muller;Tyler Brau;Thomas Lauer;Dwight Stoll;A. de Villiers - 通讯作者:
A. de Villiers
Dwight Stoll的其他文献
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{{ truncateString('Dwight Stoll', 18)}}的其他基金
GOALI: Innovative Interfaces for Two-Dimensional Liquid Chromatography
GOALI:二维液相色谱的创新接口
- 批准号:
2003734 - 财政年份:2020
- 资助金额:
$ 21.28万 - 项目类别:
Standard Grant
Collaborative Research: System Optimization and Data Analysis in Two-Dimensional Liquid Chromatography
合作研究:二维液相色谱系统优化和数据分析
- 批准号:
1213244 - 财政年份:2012
- 资助金额:
$ 21.28万 - 项目类别:
Standard Grant
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