Novel roles for importin alpha proteins in the nucleus

该项目将提供关于输入素(IMP)α蛋白如何通过基因转录变化和细胞内运输变化影响细胞功能变化的基本新信息。这些发现将为国家优先领域提供信息，包括衰老良好、在细胞应激反应方面的生产性衰老，以及在生产健康、基因完整的精子的背景下的健康生命开始。这个项目召集了一个国际团队来研究一种现象，这一现象对新的理解正常的发育过程和细胞/组织对疾病条件的反应具有意义。

The project will provide fundamental new information about how changes in cell function are influenced by importin (IMP) alpha proteins, both through changes in gene transcription and through alterations to intracellular transport. These findings will inform areas of national priority that include Aging Well, Aging Productively with specific regard to cellular stress responses, and A Healthy Start to Life in the context of production of healthy, genetically intact sperm. This project draws together an international team to investigate a phenomenon with implications for new understanding of normal developmental processes and the response of cells/tissues to disease conditions.