Control of developmental switches by importin 5

通过导入 5 控制发育开关

• 批准号: DP200103463
• 负责人: Prof Kate Loveland
• 金额: $ 35.81万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-12 至 2023-01-11
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103463
• 关键词: Control; developmental; switches; importin

Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works. Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals. Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment. Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.

目标：该项目将研究一种名为IPO5的关键分子开关，这是一种细胞和器官正常形成和功能所需的蛋白质，并将揭示其工作原理。 意义：这些实验将提供第一个完整的描述，说明这种分子开关如何在细胞的整个生命周期内控制其行为。IPO5是高度保守的，因此这些研究将与广泛的动物相关。 预期结果：这一知识将揭示IPO5如何通过揭示它与哪些其他蛋白质结合来控制精子的形成，以及这如何影响细胞信号和对环境的反应。 好处：这将提供有关控制生育或修复异常细胞的潜在干预措施的信息。