UNS:Collaborative Research: Coded-illumination Fourier Ptychography for High-content Multimodal Imaging

摘要(协作)Pi：Zeng，Guoan Proposal：1510077PI：DiMarzio，CharlesProposal：1510280本项目将开发一种新型的原型显微镜，具有超高分辨率的超高灵敏度，同时具有在大视场下提供3D成像和快速成像的能力。该提议旨在开发一种新型的显微技术(编码照明傅里叶层析)，该技术结合了新颖的傅里叶数据恢复、组织切片的结构照明、多层建模和光谱多路复用的创新。跨数据采集的迭代用于优化最终的映像解决方案。增加图像的维度，无论是光谱的还是空间的，都是一种非常理想的商品。如果这些技术能够成为常规技术，那么显微镜的许多领域都会受益。该提案反映了对女性的大量接触，以及对毕业生和本科生的重大教育努力。

Abstract (Collaborative)PI: Zheng, GuoanProposal:1510077PI: DiMarzio, CharlesProposal: 1510280This project will develop a new prototype microscope of ultra-high sensitivity with super-high resolution, yet with the ability to provide 3D imaging at a large field-of-view and rapid imaging.The proposal aims to develop a new type of microscopy technique, (coded-illumination Fourier ptychography), that incorporates the innovations of novel Fourier data recovery, structured illumination for tissue sectioning, multi-layer modeling, and spectrum multiplexing. Iteration across data acquisitions is used to optimize to a final image solution. Increased image dimensionality, either spectral or spatial, is a highly desired commodity. If these techniques can be made routine, then many areas of microscopy could benefit. The proposal reflects substantial outreach to women and significant educational efforts towards graduates and undergraduates..