UNS: Collaborative Research: Wall Shear Stress Sensor for Engineering Fluid Dynamics in Biomedical Systems

建议：1512553 /1512553 PI：Frakes，大卫/ Sodana，亨利拟议的研究计划很可能提供基础知识，有用的研究技术，在生物医学领域有关脑动脉瘤和类似的相关病理学。该计划的重点是壁剪切应力传感器的开发和应用，以提高对脑动脉瘤流体动力学的基本理解，创建解决类似问题的原型，并支持流体动力学工程在人类健康背景下的长期发展。脑动脉瘤影响超过5%的人口，在美国超过1700万人。它们导致10%的中风，破裂后的死亡率为65%。尽管有直接的临床证据将治疗后血流动力学与结果联系起来，但支持治疗成功的具体血流动力学尚不清楚。这种理解上的差距阻碍了更成功的治疗方法的设计和执行。为了改善这个问题的解决方案，以及它所描述的更广泛的问题，拟议的研究计划将通过以下方式推进生物医学系统的传感：建立用于流体动力学实验的脑动脉瘤物理模型，开发用于直接测量壁剪切应力的纳米结构传感器，在良好控制的条件下表征和分析新型剪切应力传感器，并通过在动脉瘤模型中使用传感器来表征传感器，以了解动脉瘤流动。 该研究计划的智力优势是：用于直接测量壁面剪切应力的新型纳米结构传感器，物理，计算和流体动力学脑动脉瘤库，以及推进生物医学系统中流体动力学的现有知识。 研究计划的更广泛影响包括：以新型传感器和广泛传播的脑动脉瘤图书馆的形式增强研究和教育基础设施（包括物理和计算模型以及流体动力学数据），本科生研究项目和本科生/研究生课堂案例研究，与研究和行业专业人士的新伙伴关系，以及对社会的影响，包括降低医疗保健成本，提高人类生活质量和寿命。该计划的主要教育目标是增加对关键但不可用的工程技术的接触，并扩大对工程的参与。为了实现这些目标，教育计划将通过基于驱动研究计划的核心技术的多媒体课程吸引学生，从而将拟议的研究直接与教育相结合。 脑动脉瘤对西班牙裔和女性的影响不成比例。这一事实将被用来从科学和工程领域代表性不足的群体中招募研究和教育项目的参与者。这些计划将使当地和全球的多个群体（研究人员，患者，学生，代表性不足的群体）和机构（学术界，工业界，医疗保健，教育）受益。

Proposals: 1512553 / 1512553PIs: Frakes, David / Sodana, HenryThe proposed research program is likely to provide fundamental knowledge, useful research techniques in the biomedical field related to cerebral aneurysms and similar related pathology. The program focuses on the development and application of wall shear stress sensors to improve fundamental understanding of cerebral aneurysm fluid dynamics, create a prototype for addressing similarly posed problems, and underpin long-term advancement of fluid dynamic engineering in the context of human health. Cerebral aneurysms affect over 5% of the population, which translates to more than 17 million people in the United States. They cause 10% of strokes and have a mortality rate of 65% after rupture. Although there is direct clinical evidence linking post-treatment hemodynamics to outcomes, the specific hemodynamics that underpin treatment success are not clear. This gap in understanding prevents the design and execution of more successful treatments. To improve solutions for this problem, and the broader class of problems it exemplifies, the proposed research program will advance sensing of biomedical systems through: create physical models of cerebral aneurysms for fluid dynamic experiments, develop nanostructured sensors for measuring wall shear stress directly, characterize and analyze the novel shear stress sensors under well-controlled conditions, and characterize the sensors by using them in the aneurysm models for understanding aneurysmal flows. Intellectual merits of the research program are: novel nanostructured sensors for measuring wall shear stress directly, a physical, computational, and fluid dynamic cerebral aneurysm library, and advance current knowledge of fluid dynamics in biomedical systems. Broader impacts of the research program include: enhanced infrastructure for research and education in the forms of novel sensors and a broadly disseminated cerebral aneurysm library (including both physical and computational models and fluid dynamic data), undergraduate research projects and undergraduate/graduate classroom case studies, newly generated partnerships with research and industry professionals, and impacts on society including reduced healthcare costs and improved quality and duration of human life. The primary educational goals of this program are to increase exposure to crucial but unavailable engineering technologies and to broaden participation in engineering. Toward those goals, the education program will engage students through multimedia curricula based the core technologies that drive the research program, thereby integrating the proposed research directly with education. Cerebral aneurysms affect both Hispanics and women disproportionately. This fact will be leveraged to recruit research and education program participants from groups that are underrepresented in science and engineering. The programs will benefit multiple groups (researchers, patients, students, underrepresented groups) and institutions (academia, industry, healthcare, education) both locally and globally.