UNS: Collaborative Research: Wall Shear Stress Sensor for Engineering Fluid Dynamics in Biomedical Systems

提案：1512553 / 1512553pi: Frakes， David / Sodana， henry拟议的研究项目可能提供与脑动脉瘤和类似相关病理学相关的生物医学领域的基础知识和有用的研究技术。该项目侧重于壁面剪切应力传感器的开发和应用，以提高对脑动脉瘤流体动力学的基本理解，为解决类似的问题创建一个原型，并在人类健康的背景下巩固流体动力学工程的长期进步。脑动脉瘤影响了超过5%的人口，也就是美国超过1700万人。它们导致10%的中风，破裂后的死亡率为65%。尽管有直接的临床证据将治疗后的血流动力学与结果联系起来，但支撑治疗成功的具体血流动力学尚不清楚。这种认识上的差距阻碍了设计和实施更成功的治疗方法。为了改进这个问题的解决方案，以及它所体现的更广泛的问题类别，拟议的研究计划将通过以下方式推进生物医学系统的传感：建立脑动脉瘤物理模型用于流体动力学实验，开发用于直接测量壁面剪切应力的纳米结构传感器，在良好控制条件下对新型剪切应力传感器进行表征和分析，并将其用于动脉瘤模型中以了解动脉瘤流动。该研究项目的智力优势在于：用于直接测量壁面剪切应力的新型纳米结构传感器，物理、计算和流体动力学脑动脉瘤库，以及推进生物医学系统中流体动力学的当前知识。该研究项目的更广泛影响包括：以新型传感器和广泛传播的脑动脉瘤库（包括物理和计算模型以及流体动力学数据）的形式加强研究和教育的基础设施，本科生研究项目和本科生/研究生课堂案例研究，与研究和行业专业人士建立的新伙伴关系，以及对社会的影响，包括降低医疗保健成本和提高人类生活质量和延长寿命。该计划的主要教育目标是增加对关键但不可用的工程技术的接触，并扩大对工程的参与。为了实现这些目标，教育计划将通过多媒体课程吸引学生，这些课程基于推动研究计划的核心技术，从而将拟议的研究直接与教育结合起来。脑动脉瘤对西班牙裔和女性的影响不成比例。这一事实将被用来从科学和工程领域代表性不足的群体中招募研究和教育项目的参与者。这些项目将惠及本地和全球的多个群体（研究人员、患者、学生、代表性不足的群体）和机构（学术界、工业界、医疗保健、教育）。

Proposals: 1512553 / 1512553PIs: Frakes, David / Sodana, HenryThe proposed research program is likely to provide fundamental knowledge, useful research techniques in the biomedical field related to cerebral aneurysms and similar related pathology. The program focuses on the development and application of wall shear stress sensors to improve fundamental understanding of cerebral aneurysm fluid dynamics, create a prototype for addressing similarly posed problems, and underpin long-term advancement of fluid dynamic engineering in the context of human health. Cerebral aneurysms affect over 5% of the population, which translates to more than 17 million people in the United States. They cause 10% of strokes and have a mortality rate of 65% after rupture. Although there is direct clinical evidence linking post-treatment hemodynamics to outcomes, the specific hemodynamics that underpin treatment success are not clear. This gap in understanding prevents the design and execution of more successful treatments. To improve solutions for this problem, and the broader class of problems it exemplifies, the proposed research program will advance sensing of biomedical systems through: create physical models of cerebral aneurysms for fluid dynamic experiments, develop nanostructured sensors for measuring wall shear stress directly, characterize and analyze the novel shear stress sensors under well-controlled conditions, and characterize the sensors by using them in the aneurysm models for understanding aneurysmal flows. Intellectual merits of the research program are: novel nanostructured sensors for measuring wall shear stress directly, a physical, computational, and fluid dynamic cerebral aneurysm library, and advance current knowledge of fluid dynamics in biomedical systems. Broader impacts of the research program include: enhanced infrastructure for research and education in the forms of novel sensors and a broadly disseminated cerebral aneurysm library (including both physical and computational models and fluid dynamic data), undergraduate research projects and undergraduate/graduate classroom case studies, newly generated partnerships with research and industry professionals, and impacts on society including reduced healthcare costs and improved quality and duration of human life. The primary educational goals of this program are to increase exposure to crucial but unavailable engineering technologies and to broaden participation in engineering. Toward those goals, the education program will engage students through multimedia curricula based the core technologies that drive the research program, thereby integrating the proposed research directly with education. Cerebral aneurysms affect both Hispanics and women disproportionately. This fact will be leveraged to recruit research and education program participants from groups that are underrepresented in science and engineering. The programs will benefit multiple groups (researchers, patients, students, underrepresented groups) and institutions (academia, industry, healthcare, education) both locally and globally.