GOALI: Collaborative Research: Integrated Biomimetic Block Copolymer Composite Membranes

GOALI：合作研究：集成仿生嵌段共聚物复合膜

• 批准号: 1512099
• 负责人: Manish Kumar
• 金额: $ 19.47万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1512099&HistoricalAwards=false
• 关键词: GOALI; Collaborative; Research; Integrated; Biomimetic

1512089/1512099Phillip/KumarNotre Dame/Penn StateMimicking biological membranes, which have developed innovative transport mechanisms through millennia of evolution, has gained increasing interest in recent years. In particular, biological membranes have embedded proteins that are capable of transporting chemical species into and out of cells efficiently and with exceptional selectivity. As such, developing membrane platforms that mimic the exquisite processes of biology provides a route toward performing many chemical separations that are critical to modern society (e.g., purification of drinking water). In order for these advanced membranes to make an impact on the chemical and biological separations the development of robust, high performance, composite membranes is required. These composite membranes comprise a biomimetic active layer containing membrane proteins supported mechanically by a highly-porous and permeable support layer. The generation of robust composite membranes, which realize the full potential of membrane proteins, requires that the active and support layers are integrated synergistically.The goal of the proposed research project is to identify the key materials relationships that control the interplay between the nanostructures and chemistries of the copolymer supports and the biomimetic active layers in order to optimize the separations performance of composite biomimetic-block copolymer membranes (BBCMs). This novel class of membranes comprises a selective layer made from 2D crystals of membrane proteins and a support layer made from self-assembled copolymers. The successful execution of this research project will deliver a transformative technology platform through an enhanced understanding of how to combine two self-assembled materials into a composite membrane relevant to a diversity of separations. Beyond the technical impact, a new generation of graduate, undergraduate, and high school students will be trained in a multi-disciplinary and collaborative setting. A summer camp for middle school students focused on water treatment will provide opportunities to bring this important application of membranes to a wider audience.

1512089/1512099 Phillip/KumarNotre Dame/Penn State模仿生物膜经过数千年的进化发展出了创新的传输机制，近年来得到了越来越多的关注。特别是，生物膜具有嵌入的蛋白质，能够有效地将化学物种输送进和运出细胞，并具有特殊的选择性。因此，开发模拟生物学精细过程的膜平台为实现对现代社会至关重要的许多化学分离提供了一条途径(例如，净化饮用水)。为了使这些先进的膜对化学和生物分离产生影响，需要开发坚固、高性能的复合膜。这些复合膜包括包含膜蛋白的仿生活性层，膜蛋白由高度多孔和可渗透的支撑层机械支撑。充分发挥膜蛋白潜力的复合膜的形成需要活性层和支撑层的协同集成。本研究的目标是确定控制共聚物支撑体的纳米结构和化学性质与仿生活性层之间相互作用的关键材料关系，以优化复合仿生嵌段共聚物膜的分离性能。这类新型膜包括由膜蛋白2D晶体组成的选择层和由自组装共聚物组成的支撑层。这一研究项目的成功实施将提供一个变革性的技术平台，通过加强对如何将两种自组装材料结合成与各种分离相关的复合膜的理解。除了技术影响，新一代研究生、本科生和高中生将在多学科和协作的环境中接受培训。为中学生举办的以水处理为重点的夏令营将提供机会，将膜的这一重要应用带给更广泛的受众。