CAREER: Bioinspired Artificial Channel Water Treatment Membranes

职业：仿生人工渠道水处理膜

• 批准号: 1946392
• 负责人: Manish Kumar
• 金额: $ 8.9万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1946392&HistoricalAwards=false
• 关键词: CAREER; Bioinspired; Artificial; Channel; Water

1552571KumarThe goal of this CAREER program is to utilize the principal investigator's (PI's) diverse industrial and academic experience to build an integrated research, education ,and outreach program centered on bioinspired membranes for water treatment. This program is relevant to food-energy-water nexus problems and solutions. Artificial water channels, a new class of channels made using organic synthesis, were recently demonstrated by the PI to have permeability properties similar to biological water channels, or aquaporins, and their current synthetic analogs, carbon nanotubes. This research approach has the potential to be a "game changer" in membrane treatment of water.The technical goal of this project is to design and synthesize a new class of membranes based on peptide-appended pillar[5]arene channels. The central hypothesis of the proposed work is: Solvent compatible channels will enable the scalable synthesis of practical ultra-permeable channel-based membranes. The scientific research objectives of the program are: 1) Understand the effect of angstrom-scale pore properties of diameter, hydrophobicity, and charge, on selectivity and water permeability using model peptide-appended pillar[5]arene channels; 2) Explore the compatibility of peptide-appended pillar[5]arene channels with block copolymer membranes and use this knowledge to maximize channel packing; and, 3) Correlate the structure and transport properties of peptide-appended pillar[5]arene block copolymer membranes. The tunable pore size will allow application of these membranes across critical areas of water treatment and reuse including: 1) drinking water treatment, 2) brackish water and seawater desalination, and, 3) wastewater reuse. The compact nature of membrane technology will allow its implementation in decentralized treatment as well as in low footprint centralized treatment in dense urban areas. Overall, given the increasing pressure on water sources and the interconnectedness of energy, food, and water operations, success in the proposed program can have a significant impact on the food-energy-water nexus. The proposed program will utilize bioinspired membranes and their connection to water transport in natural systems, such as plants and the human body, to engage diverse students at all levels (K-12 though graduate) in multidisciplinary research and education activities. The three specific educational objectives of the proposed program are: 1) Provide early stage mentorship to a diverse multidisciplinary group of engineering undergraduates (UGs) through first year seminars and research engagement; 2) Evaluate four UG research engagement models common at universities; and 3) Expand and diversify a current water-science-based K-12 summer camp and assess its impact on participants.

1552571 Kumar这个职业计划的目标是利用首席研究员（PI）的多样化的工业和学术经验，以建立一个综合的研究，教育和推广计划为中心的生物膜水处理。该方案涉及粮食-能源-水的关系问题和解决办法。人工水通道，一种使用有机合成制成的新型通道，最近被PI证明具有类似于生物水通道或水通道蛋白及其目前的合成类似物碳纳米管的渗透性。该研究方法有可能成为水膜处理领域的“游戏规则改变者”。本项目的技术目标是设计和合成一类基于肽附加柱[5]芳烃通道的新型膜。拟议工作的中心假设是：溶剂相容性通道将使实用的基于超渗透通道的膜的可扩展合成成为可能。该计划的科学研究目标是：1）了解使用模型肽附加柱[5]芳烃通道的直径，疏水性和电荷的埃级孔性质对选择性和水渗透性的影响; 2）探索肽附加柱[5]芳烃通道与嵌段共聚物膜的相容性，并利用这些知识最大化通道填充;以及，3）关联肽附加的柱[5]芳烃嵌段共聚物膜的结构和传输性质。可调孔径将允许这些膜在水处理和再利用的关键领域中应用，包括：1）饮用水处理，2）微咸水和海水淡化，以及3）废水再利用。膜技术的紧凑性将使其能够在分散处理以及密集城市地区的低足迹集中处理中实施。总的来说，考虑到对水源的压力越来越大，以及能源、粮食和水的相互联系，拟议计划的成功可能会对粮食-能源-水的关系产生重大影响。拟议的计划将利用生物启发膜及其与自然系统（如植物和人体）中的水运输的连接，让各级学生（K-12尽管研究生）参与多学科研究和教育活动。拟议计划的三个具体教育目标是：1）通过第一年的研讨会和研究参与，为工程本科生（UG）的多元化多学科群体提供早期指导; 2）评估大学常见的四个UG研究参与模式; 3）扩大和多样化目前基于水科学的K-12夏令营，并评估其对参与者的影响。

项目成果

Membrane Protein Insertion into and Compatibility with Biomimetic Membranes

膜蛋白插入仿生膜并与仿生膜相容

• DOI: 10.1002/adbi.201700053
• 发表时间: 2017
• 期刊: Advanced Biosystems
• 影响因子: 4.1
• 作者: Ren, Tingwei;Erbakan, Mustafa;Shen, Yuexiao;Barbieri, Eduardo;Saboe, Patrick;Feroz, Hasin;Yan, Hengjing;McCuskey, Samantha;Hall, Joseph F.;Schantz, A. Benjamin
• 通讯作者: Schantz, A. Benjamin

Conference demographics and footprint changed by virtual platforms

• DOI: 10.1038/s41893-021-00823-2
• 发表时间: 2021-12-09
• 期刊: NATURE SUSTAINABILITY
• 影响因子: 27.6
• 作者: Skiles, Matthew;Yang, Euijin;Kumar, Manish
• 通讯作者: Kumar, Manish

Design Considerations for Artificial Water Channel–Based Membranes

基于膜的人工水道的设计注意事项

• DOI: 10.1146/annurev-matsci-070317-124544
• 发表时间: 2018
• 期刊: Annual Review of Materials Research
• 影响因子: 9.7
• 作者: Song, Woochul;Lang, Chao;Shen, Yue-xiao;Kumar, Manish
• 通讯作者: Kumar, Manish

Porous Vesicles with Extrusion-Tunable Permeability and Pore Size from Mixed Solutions of PEO-PPO-PEO Triblock Copolymers

PEO-PPO-PEO 三嵌段共聚物混合溶液中具有挤出可调渗透性和孔径的多孔囊泡

• DOI: 10.1002/macp.201700620
• 发表时间: 2018
• 期刊: Macromolecular Chemistry and Physics
• 影响因子: 2.5
• 作者: Schantz, A. Benjamin;Ren, Tingwei;Pachalla, Abhishek;Shen, Yuexiao;Hickey, Robert J.;Kumar, Manish
• 通讯作者: Kumar, Manish

Nanostructured block copolymer muscles

• DOI: 10.1038/s41565-022-01133-0
• 发表时间: 2022-06-02
• 期刊: NATURE NANOTECHNOLOGY
• 影响因子: 38.3
• 作者: Lang, Chao;Lloyd, Elisabeth C.;Hickey, Robert J.
• 通讯作者: Hickey, Robert J.