SusChEM:Characterization of oxidative stress response to improve microalgae-based biofuel production in wastewater
SusChEM:氧化应激反应的表征,以提高废水中基于微藻的生物燃料的生产
基本信息
- 批准号:1512250
- 负责人:
- 金额:$ 29.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-15 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PI: Annaliese FranzProposal Number: 1512250Microalgae are single-celled photosynthetic organisms that grow on atmospheric carbon dioxide, sunlight, and dissolved mineral nutrients. Under the proper conditions, microalgae also produce fatty acids stored as lipids, which can be readily converted to biofuel such as biodiesel. To reduce the costs of algal biofuel production processes and at the same time improve sustainable reuse of water, algae can be grown on dissolved mineral nutrients in various types of waste water. However, the use of waste water as nutrient source may put stress on the growth and metabolism of the organism. This project will study the possible link between oxidative stress and lipid production in industrially-relevant strains of microalgae using techniques of molecular biology. The outcomes of the research may suggest ways to minimally treat waste water to make it more amenable for use in algal biofuel production. The educational aspects of this project focus on mentoring middle school girls to stimulate their interest in science and engineering using bioenergy modules developed for this purpose.The overall goal of this research is to characterize oxidative stress response and regulation of gene expression in industrially-relevant microalgae strains in order to identify improved conditions for coupling biofuel production with wastewater remediation. The overall approach is to correlate relevant phenotypes with metabolomic and transcriptomic studies for lipid producing strains of microalgae to understand global metabolism and lipid pathway changes under conditions that promote oxidative stress response, including kinetic and concentration effects of treated cultures with a primary focus on algae cultivation in wastewater. High lipid producing strains (P. tricornutum, C. sorokiniana and N. salina) will be selected for study based on their industrial and scientific relevance as well as availability of genomic information. The research plan has three objectives. The first objective is to characterize oxidative stress response and regulation of gene expression in lipid producing microalgae, including kinetic and concentration effects for two scenarios - peroxide-induced lipid accumulation and cultivation on dairy wastewater. The second objective is to evaluate application of antioxidants to improve oxidative stress tolerance in high-oil-producing microalgae. Finally, the third objective is to evaluate effect of peroxide- and antioxidant treatment as variables to improve biomass and lipid production of microalgae cultured in wastewater. The education and outreach activities of this project focus on bioenergy topics, and are designed to broaden participation of women and under-represented students in STEM through existing programs at the University of California at Davis, particularly for middle school girls. A bioenergy module focusing on renewable energy and environmental sustainability will be developed to help deliver these education and outreach programs.
主要研究者:Annaliese Franz提案编号:1512250微藻是单细胞光合生物,依靠大气中的二氧化碳、阳光和溶解的矿物质营养生长。 在适当的条件下,微藻也会产生以脂类形式储存的脂肪酸,这些脂肪酸可以很容易地转化为生物燃料,如生物柴油。 为了降低藻类生物燃料生产过程的成本,同时提高水的可持续再利用,藻类可以在各种废水中溶解的矿物质营养素上生长。 然而,使用废水作为营养源可能会对生物体的生长和代谢造成压力。 该项目将利用分子生物学技术研究氧化应激和工业相关微藻菌株中脂质生产之间的可能联系。 这项研究的结果可能会提出最低限度地处理废水的方法,使其更适合用于藻类生物燃料生产。 该项目的教育方面侧重于指导中学女生,以激发她们对科学和工程的兴趣,使用为此目的开发的生物能源模块。该研究的总体目标是表征工业相关微藻菌株中的氧化应激反应和基因表达调控,以确定将生物燃料生产与废水治理相结合的改善条件。 总体方法是将相关表型与微藻产脂菌株的代谢组学和转录组学研究相关联,以了解在促进氧化应激反应的条件下的全球代谢和脂质途径变化,包括处理过的培养物的动力学和浓度效应,主要关注废水中的藻类培养。 高脂菌株(三角褐指藻、C. sorokiniana和N. salina)将根据其工业和科学相关性以及基因组信息的可用性选择进行研究。研究计划有三个目标。 第一个目标是表征脂质产生微藻的氧化应激反应和基因表达调控,包括两种情况下的动力学和浓度效应-过氧化物诱导的脂质积累和培养对乳品废水的影响。 第二个目的是评估抗氧化剂在提高高产油微藻的氧化应激耐受性中的应用。 最后,第三个目标是评估过氧化氢和抗氧化剂处理作为变量的效果,以提高废水中培养的微藻的生物量和脂质产量。该项目的教育和外联活动侧重于生物能源主题,旨在通过加州大学戴维斯分校的现有方案,扩大妇女和代表性不足的学生,特别是中学女生对科学、技术、工程和数学的参与。 将开发一个侧重于可再生能源和环境可持续性的生物能源模块,以帮助提供这些教育和推广方案。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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Annaliese Franz其他文献
Growth potential of microalgae on ammonia-rich anaerobic digester effluent for wastewater remediation
- DOI:
10.1016/j.algal.2021.102613 - 发表时间:
2022-03-01 - 期刊:
- 影响因子:
- 作者:
Kayla Rude;Cody Yothers;Tyler J. Barzee;Serena Kutney;Ruihong Zhang;Annaliese Franz - 通讯作者:
Annaliese Franz
Economic and environmental performance of microalgal energy products – A case study exploring circular bioeconomy principles applied to recycled anaerobic digester waste flows
微藻能源产品的经济和环境绩效——一个探索应用于循环生物经济原则的回收厌氧消化器废物流的案例研究
- DOI:
10.1016/j.jenvman.2024.120802 - 发表时间:
2024-05-01 - 期刊:
- 影响因子:8.400
- 作者:
Jin Wook Ro;Cody Yothers;Alissa Kendall;Annaliese Franz;Ruihong Zhang - 通讯作者:
Ruihong Zhang
Annaliese Franz的其他文献
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{{ truncateString('Annaliese Franz', 18)}}的其他基金
Enantioenriched Silanol and Siloxy Compounds as Catalysts and Ligands
作为催化剂和配体的对映体富集的硅烷醇和甲硅烷氧基化合物
- 批准号:
1900300 - 财政年份:2019
- 资助金额:
$ 29.98万 - 项目类别:
Standard Grant
REU Site: UC Davis ChemEnergy Research Experience for Undergraduates in Energy and Catalysis
REU 网站:加州大学戴维斯分校化学能源本科生能源和催化研究经验
- 批准号:
1560479 - 财政年份:2016
- 资助金额:
$ 29.98万 - 项目类别:
Standard Grant
SusChEM: Design and Mechanistic Studies of Organic Silanols for Homogeneous Catalysis
SusChEM:均相催化有机硅烷醇的设计和机理研究
- 批准号:
1363375 - 财政年份:2014
- 资助金额:
$ 29.98万 - 项目类别:
Standard Grant
CAREER: Synthesis and Study of Organic Silanols for Asymmetric Catalysis
职业:用于不对称催化的有机硅烷醇的合成和研究
- 批准号:
0847358 - 财政年份:2009
- 资助金额:
$ 29.98万 - 项目类别:
Standard Grant
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