Enantioenriched Silanol and Siloxy Compounds as Catalysts and Ligands

作为催化剂和配体的对映体富集的硅烷醇和甲硅烷氧基化合物

• 批准号: 1900300
• 负责人: Annaliese Franz
• 金额: $ 45万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1900300&HistoricalAwards=false
• 关键词: Enantioenriched; Silanol; Siloxy; Compounds; Catalysts

With this award, the Chemical Catalysis Program of the NSF Division of Chemistry is supporting the research of Professor Annaliese Franz in the Department of Chemistry at the University of California, Davis. Professor Franz is developing new silicon-based molecules and using them to prepare structurally-defined complexes with metals. These complexes are being studied as catalysts for applications such as the efficient synthesis of organic materials and renewable polymers that are used in technology, medicine, and daily life. The use of catalysts is important for increasing industrial efficiency in advanced manufacturing and reducing waste production. Silicon is the second most abundant element in the earth's crust, as such this research is addressing issues of sustainability. This project alsocontributes to training the next generation of scientists and broadening participation. Dr. Franz engages in mentoring and outreach activities to broaden participation in STEM, including demonstrations and workshops for 7th and 8th grade girls with AAUW TechTrek and STEM for Girls. She also designs and implements a First-year Seminar - CURE (Course-based Undergraduate Research Experience) - to engage a diverse group of first-year and transfer students with hands-on research opportunities to build critical skills that will help launch them into careers in science and technology.This project aims to develop new metal-siloxide complexes with high catalytic activity and selectivity for the synthesis of chiral molecules. The design and synthesis of four new classes of chiral siloxy compounds is being investigated to prepare chiral ligands. Using these newly designed silanol ligands, a series of novel metal-siloxide complexes is being prepared where the metal-coordinating abilities, structural studies, stability, and catalytic activity are examined. The structure, binding interactions, and mechanism of the new catalysts are being studied using various spectroscopy methods, kinetics, X-ray crystallography, and mass spectrometry. This project is also training undergraduate and graduate students to develop technical and critical thinking skills for chemical synthesis and catalysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

通过这个奖项，美国国家科学基金会化学部的化学催化项目正在支持加州大学戴维斯分校化学系Annaliese Franz教授的研究。弗朗茨教授正在开发新的硅基分子，并用它们来制备结构明确的金属复合物。人们正在研究这些配合物作为催化剂的应用，如在技术、医学和日常生活中使用的有机材料和可再生聚合物的高效合成。催化剂的使用对提高先进制造业的工业效率和减少废物产生具有重要意义。硅是地壳中第二丰富的元素，因此这项研究正在解决可持续性问题。该项目还有助于培养下一代科学家和扩大参与。Franz博士从事指导和外展活动，以扩大STEM的参与，包括AAUW TechTrek和STEM for girls的七年级和八年级女孩的示范和研讨会。她还设计并实施了一个一年级研讨会——CURE（基于课程的本科研究经验）——让不同群体的一年级和转学生有机会动手研究，培养关键技能，帮助他们进入科学和技术领域。本项目旨在开发具有高催化活性和选择性的新型金属硅氧化物配合物，用于手性分子的合成。设计和合成了四类新的手性硅氧基化合物，以制备手性配体。利用这些新设计的硅醇配体，制备了一系列新型的金属-硅氧化物配合物，并对其金属配位能力、结构研究、稳定性和催化活性进行了测试。利用各种光谱方法、动力学、x射线晶体学和质谱法对新型催化剂的结构、结合相互作用和机理进行了研究。该项目还训练本科生和研究生发展化学合成和催化的技术和批判性思维技能。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Ligand-Accelerated Catalysis in Scandium(III)-Catalyzed Asymmetric Spiroannulation Reactions

• DOI: 10.1021/acscatal.1c05768
• 发表时间: 2022-03
• 期刊: ACS Catalysis
• 影响因子: 12.9
• 作者: Nicolas R. Ball‐Jones;Angel A. Cobo;Brittany M. Armstrong;Benjamin Wigman;J. Fettinger;J. Hein;A. Franz

NMR Quantification of Halogen-Bonding Ability To Evaluate Catalyst Activity

• DOI: 10.1021/acs.orglett.0c02427
• 发表时间: 2020-08-21
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Chang, Yun-Pu;Tang, Teresa;Franz, Annaliese K.
• 通讯作者: Franz, Annaliese K.