EAPSI: Inkjet Printed Paper-Based Chemical Sensor for Vitamin E

EAPSI：喷墨印刷纸基维生素 E 化学传感器

• 批准号: 1515412
• 负责人: Casey Grenier
• 金额: $ 0.51万
• 依托单位: Grenier Casey J
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1515412&HistoricalAwards=false
• 关键词: EAPSI; Inkjet; Printed; Paper; Based

Measuring the amount of vitamin E present in blood is difficult because of the complex nature of blood, overall cost, amount of time, and instrumentation involved. The development of a chemical sensor ink, which is then printed onto paper, would be a novel approach to determining vitamin E levels in biological fluids. For years, people have been using ink jet printing in their homes and offices; however, it has transitioned from an office and home application to an application for chemical sensing. Modern inkjet printers support the creation of precise and contactless deposition of microscopic sized droplets of the chemical sensor onto paper. This award supports research that combines inkjet printing with molecular imprinted polymers (MIPs) to develop a new sensor that can be used to test levels of Vitamin E in bodily fluids. This research will be conducted in collaboration with Dr. Daniel Citterio at Keio University in Tokyo Japan, who is an expert in inkjet printing technology for the development of microfluidic paper-based analytical devises. Results from this collaboration could allow for a point of care testing system that would be accurate, precise, reproducible, and overall cheaper than current blood testing methods. The proposed chemical sensor would utilize an aqueous, non-covalently crosslinked network, MIP as an ink to be printed onto paper based substrates. The key challenge that must be overcome is creating an MIP that is both aqueous and presents a strong and selective binding affinity for vitamin E. MIP will be formulated and printed onto paper so that vitamin E levels can be measured using a fluorescence response indicator. Dr. Citterio?s group was the first to demonstrate the function of using ink jet printing for the deposition of biochemical sensors by microfluidic patterning of the substrates. Creating such a technology could have multiple uses in many different fields as a new class of chemical sensors. The NSF EAPSI award is funded in collaboration with the Japan Society for the Promotion of Science.

测量血液中维生素E的含量是困难的，因为血液的复杂性，总成本，时间量和所涉及的仪器。开发一种化学传感器墨水，然后将其打印到纸上，这将是一种确定生物液体中维生素E水平的新方法。多年来，人们一直在家庭和办公室使用喷墨打印;然而，它已经从办公室和家庭应用过渡到化学传感应用。现代喷墨打印机支持将化学传感器的微观尺寸的液滴精确且非接触地沉积到纸上。该奖项支持将喷墨打印与分子印迹聚合物（MIPs）相结合的研究，以开发可用于测试体液中维生素E水平的新传感器。这项研究将与日本东京庆应义塾大学的丹尼尔奇特里奥博士合作进行，他是开发微流体纸基分析装置的喷墨打印技术专家。这项合作的结果可以实现一种准确、精确、可重复且总体上比当前血液检测方法更便宜的即时检测系统。所提出的化学传感器将利用水性非共价交联网络MIP作为印刷到纸基基底上的油墨。必须克服的关键挑战是创建一种MIP，该MIP既是水性的，又对维生素E具有强大的选择性结合亲和力。MIP将配制并打印在纸上，以便使用荧光反应指示剂测量维生素E水平。奇特里奥医生的小组是第一个证明使用喷墨打印的功能，用于沉积生化传感器的微流体图案的基板。创造这样一种技术可以在许多不同的领域作为一类新的化学传感器有多种用途。NSF EAPSI奖是与日本科学促进会合作资助的。