SBIR Phase I: Microfluidics-Enabled Interfacial Capacitive Sensing

SBIR 第一阶段：微流控界面电容传感

• 批准号: 1520481
• 负责人: Baoqing Nie
• 金额: $ 15万
• 依托单位: TacSense, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1520481&HistoricalAwards=false
• 关键词: SBIR; Phase; Microfluidics; Enabled; Interfacial

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project includes the development of novel microfluidic-enabled interfacial capacitive sensing solutions for a wide range of existing and emerging applications, including medical devices, robotics or consumer electronics. Upon successful completion of this SBIR Phase I project, the interfacial capacitive sensors could offer a transformative solution to various medical and industrial applications, where high sensitivity, flexibility and miniature footprints are required. By translating the early-stage laboratory discoveries into commercial pressure sensing products, the initial applications target two clinical challenges in cardiovascular medicine, fraction flow reserve measurement for patients with coronary artery stenosis and interface pressure monitoring for patients with chronic venous disease. The sensors proposed here offer unique advantages and features over the existing medical products on the market. For embedded FFR-measurement pressure sensors, these advantages include reducing the surgical time, complications, and therefore, risks during coronary cauterization. For interface pressure monitoring of compression therapy, the advantages include provides patients with more affordable, accurate, accessible, easy-to-use and comfortable-to-wear pressure sensing solution for better therapeutic outcomes.This Small Business Innovation Research (SBIR) Phase I project aims at developing the pressure sensors based on microfluidic-enabled interfacial capacitive sensing for cardiovascular applications. These include a miniature pressure sensor embedded in a coronary guide wire for fraction flow reserve evaluation, and a wearable pressure sensor with wireless transmission for interface pressure measurement in compression therapy. The proposed sensor integrated with the guide wire, once developed, allows significant reduction in electrical wiring complexity and easy procedure for surgical operations, in addition to improved structural integrity by replacing hollow wires with solid constructs. For the application of the interface pressure measurement, the interfacial capacitive sensor, upon its successful translation, would become a viable solution capable of simultaneously measuring interface pressure at multiple compression positions as well as providing real-time measurement data to both patients and clinicians. Research will be conducted on system design and manufacturing scalability of the sensors, electrical and mechanical characterizations of the sensor performance, and proof-of-concept demonstrations of potential medical sensing applications.

小型企业创新研究(SBIR)第一阶段项目的更广泛影响/商业潜力包括为医疗设备、机器人或消费电子产品等广泛的现有和新兴应用开发新型微流控界面电容传感解决方案。在这个SBIR第一阶段项目成功完成后，界面电容式传感器可以为各种医疗和工业应用提供变革性的解决方案，这些应用需要高灵敏度、灵活性和微型占地面积。通过将早期实验室发现转化为商业压力传感产品，最初的应用针对心血管医学中的两个临床挑战，即冠状动脉狭窄患者的血流储备分数测量和慢性静脉疾病患者的界面压力监测。与市场上现有的医疗产品相比，这里提出的传感器提供了独特的优势和功能。对于嵌入式FFR测量压力传感器，这些优势包括减少手术时间、减少并发症，从而减少冠状动脉烧灼术中的风险。对于压迫疗法的界面压力监测，其优势包括为患者提供更实惠、准确、可访问、易于使用和舒适的压力传感解决方案，以获得更好的治疗效果。本小企业创新研究(SBIR)一期项目旨在开发基于微流体启用的界面电容传感的心血管应用压力传感器。其中包括嵌入冠脉导丝的微型压力传感器，用于分数血流储备评估，以及具有无线传输功能的可穿戴压力传感器，用于按压治疗中的接口压力测量。建议的传感器与导丝集成在一起，一旦开发出来，除了通过用实心结构取代中空导线来改善结构完整性外，还可以显著降低电气布线的复杂性，并简化外科手术的程序。对于界面压力测量的应用，界面电容传感器一旦成功转换，将成为一种可行的解决方案，能够同时测量多个受压位置的界面压力，并为患者和临床医生提供实时测量数据。将对传感器的系统设计和制造可扩展性、传感器性能的电气和机械特性进行研究，并对潜在的医疗传感应用进行概念验证演示。