OP: High Order Perturbation of Surfaces Methods for Crossed Surface Plasmon Resonance Sensors: Simulation, Validation, and Design

OP：交叉表面等离子共振传感器的表面高阶扰动方法：仿真、验证和设计

• 批准号: 1522548
• 负责人: David Nicholls
• 金额: $ 18万
• 依托单位: University of Illinois at Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1522548&HistoricalAwards=false
• 关键词: OP; Order; Perturbation; Surfaces; Methods

Surface Plasmon Resonance (SPR) sensors are a relatively new yet pervasive technology for measuring biological and chemical interactions. These devices respond to the change in the refractive index of a structure due to the occurrence of a biological or chemical reaction. Such a change modifies the behavior of surface waves at metal-dielectric interfaces within the structure, which are then measured to form the basis for thousands of highly sensitive and effective tests for not only chemical and biological species detection, but also medical diagnosis and environmental measuring. Indeed, a 2008 survey article (J. Homola, Surface plasmon resonance sensors for detection of chemical and biological species. Chemical Reviews, 108(2):462­493, 2008) lists SPR biosensors for Food Quality and Safety Analysis (62 listed), Medical Diagnostics (33 listed), and Environmental Monitoring (21 listed). In the decade since the appearance of this publication the list has grown substantially. This project shall advance the state of the art in the numerical simulation of these SPR sensors. The numerical simulation will be validated and verified through direct collaboration with experimentalists.The algorithm of "High Order Perturbation of Surfaces" (HOPS) is optimal among the wide class of potential schemes for simulating solutions of the relevant model equations. Despite their advantageous properties for the problem at hand, the HOPS methods require further enhancements for their use by engineers. This research project aims to develop several improvements. First, the project will study extensions to the three dimensional, vectorial, multiply layered configurations of current interest. Second, the project will investigate the possibility of a joint expansion of the scattered fields in both boundary deformation and wavenumber. These latter developments will mandate new rigorous analysis (which this project will deliver) to determine their domain of applicability. Once these additions have been implemented and tested, these algorithms will be vaildated against the laboratory experimental results. After this, the project aims to create an optimization framework to design SPR sensors with enhanced sensing capabilities. This will involve the design of appropriate objective functions, followed by the efficient interfacing of the new forward solvers to state of the art minimization libraries.

表面等离子共振 (SPR) 传感器是一种相对较新但普遍的技术，用于测量生物和化学相互作用。这些装置对由于生物或化学反应的发生而导致的结构折射率的变化做出响应。这种变化改变了结构内金属-电介质界面处的表面波行为，然后对其进行测量，为数千种高灵敏度和有效测试奠定了基础，这些测试不仅用于化学和生物物种检测，还用于医学诊断和环境测量。 事实上，2008 年的一篇调查文章（J. Homola，用于检测化学和生物物种的表面等离子体共振传感器。Chemical Reviews，108(2):462493, 2008）列出了用于食品质量和安全分析（列出 62 种）、医疗诊断（列出 33 种）和环境监测（列出 21 种）的 SPR 生物传感器。自本出版物出版以来的十年中，该列表已大幅增长。该项目将推进这些 SPR 传感器数值模拟的最先进水平。数值模拟将通过与实验人员的直接合作进行验证和验证。“表面高阶扰动”(HOPS) 算法是用于模拟相关模型方程解的各种潜在方案中的最佳方案。尽管 HOPS 方法对于当前的问题具有有利的特性，但仍需要进一步增强以供工程师使用。该研究项目旨在进行多项改进。 首先，该项目将研究当前感兴趣的三维、矢量、多层配置的扩展。其次，该项目将研究散射场在边界变形和波数方面联合扩展的可能性。后面的这些发展将要求新的严格分析（本项目将提供）以确定其适用范围。一旦这些新增内容得到实施和测试，这些算法将根据实验室实验结果进行验证。此后，该项目旨在创建一个优化框架来设计具有增强传感能力的SPR传感器。这将涉及适当的目标函数的设计，然后是新的正向求解器与最先进的最小化库的有效连接。