OP: High Order Perturbation of Surfaces Methods for Crossed Surface Plasmon Resonance Sensors: Simulation, Validation, and Design

OP:交叉表面等离子共振传感器的表面高阶扰动方法:仿真、验证和设计

基本信息

  • 批准号:
    1522548
  • 负责人:
  • 金额:
    $ 18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-15 至 2019-06-30
  • 项目状态:
    已结题

项目摘要

Surface Plasmon Resonance (SPR) sensors are a relatively new yet pervasive technology for measuring biological and chemical interactions. These devices respond to the change in the refractive index of a structure due to the occurrence of a biological or chemical reaction. Such a change modifies the behavior of surface waves at metal-dielectric interfaces within the structure, which are then measured to form the basis for thousands of highly sensitive and effective tests for not only chemical and biological species detection, but also medical diagnosis and environmental measuring. Indeed, a 2008 survey article (J. Homola, Surface plasmon resonance sensors for detection of chemical and biological species. Chemical Reviews, 108(2):462­493, 2008) lists SPR biosensors for Food Quality and Safety Analysis (62 listed), Medical Diagnostics (33 listed), and Environmental Monitoring (21 listed). In the decade since the appearance of this publication the list has grown substantially. This project shall advance the state of the art in the numerical simulation of these SPR sensors. The numerical simulation will be validated and verified through direct collaboration with experimentalists.The algorithm of "High Order Perturbation of Surfaces" (HOPS) is optimal among the wide class of potential schemes for simulating solutions of the relevant model equations. Despite their advantageous properties for the problem at hand, the HOPS methods require further enhancements for their use by engineers. This research project aims to develop several improvements. First, the project will study extensions to the three dimensional, vectorial, multiply layered configurations of current interest. Second, the project will investigate the possibility of a joint expansion of the scattered fields in both boundary deformation and wavenumber. These latter developments will mandate new rigorous analysis (which this project will deliver) to determine their domain of applicability. Once these additions have been implemented and tested, these algorithms will be vaildated against the laboratory experimental results. After this, the project aims to create an optimization framework to design SPR sensors with enhanced sensing capabilities. This will involve the design of appropriate objective functions, followed by the efficient interfacing of the new forward solvers to state of the art minimization libraries.
表面等离子体共振(SPR)传感器是一种相对较新但普遍的技术,用于测量生物和化学相互作用。这些器件响应于由于生物或化学反应的发生而引起的结构的折射率的变化。这种变化改变了结构内金属-电介质界面处表面波的行为,然后对其进行测量,以形成数千种高灵敏度和有效测试的基础,不仅用于化学和生物物种检测,还用于医学诊断和环境测量。 事实上,2008年的调查文章(J. Homola,Surface plasmon resonance sensors for detection of chemical and biological species. Chemical Reviews,108(2):462 - 493,2008)列出了用于食品质量和安全分析(列出的62种)、医疗诊断(列出的33种)和环境监测(列出的21种)的SPR生物传感器。在这份出版物问世后的十年里,这份名单有了很大的增长。该项目将推进这些SPR传感器的数值模拟技术的发展。数值模拟将通过与实验人员的直接合作进行验证和核实。在用于模拟相关模型方程解的广泛类别的潜在方案中,“高阶曲面扰动”(HOPS)算法是最佳的。尽管HOPS方法对于手头的问题具有有利的特性,但对于工程师的使用,HOPS方法需要进一步增强。该研究项目旨在开发几项改进措施。 首先,该项目将研究扩展到三维,矢量,多层结构的当前利益。第二,该项目将调查在边界变形和波数方面联合扩展散射场的可能性。这些最后的发展将要求进行新的严格分析(本项目将提供),以确定其适用范围。一旦这些补充已经实施和测试,这些算法将验证对实验室的实验结果。在此之后,该项目旨在创建一个优化框架,以设计具有增强传感能力的SPR传感器。这将涉及适当的目标函数的设计,其次是新的前向求解器的最先进的最小化库的有效接口。

项目成果

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David Nicholls其他文献

An Optical Analysis of Radiation-Induced Damage in Nuclear Reactor Optical Fibres
核反应堆光纤辐射损伤的光学分析
The complex cyanides of chromium(II) and chromium(0)
  • DOI:
    10.1007/bf00618223
  • 发表时间:
    1981-08-01
  • 期刊:
  • 影响因子:
    1.700
  • 作者:
    Janice P. Eaton;David Nicholls
  • 通讯作者:
    David Nicholls
Co-ordination compounds of diacetyldihydrazone and diacetylbis(monomethylhydrazone)
  • DOI:
    10.1007/bf00935930
  • 发表时间:
    1984-04-01
  • 期刊:
  • 影响因子:
    1.700
  • 作者:
    Mark R. Harrison;David Nicholls
  • 通讯作者:
    David Nicholls
Bioenergetic actions of beta-bungarotoxin, dendrotoxin and bee-venom phospholipase A2 on guinea-pig synaptosomes.
β-银环蛇毒素、树蛇毒素和蜂毒磷脂酶 A2 对豚鼠突触体的生物能作用。
  • DOI:
    10.1042/bj2290653
  • 发表时间:
    1985
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David Nicholls;R. Snelling;Oliver;DOLLYt
  • 通讯作者:
    DOLLYt
Evaluating life cycle greenhouse gas emissions from alternative forest residue utilization: Energy and product pathways
评估替代性森林残留物利用的生命周期温室气体排放:能源与产品路径
  • DOI:
    10.1016/j.biombioe.2025.108059
  • 发表时间:
    2025-10-01
  • 期刊:
  • 影响因子:
    5.800
  • 作者:
    Poonam Khatri;Richard Bergman;Prakash Nepal;David Nicholls;Andrew Gray
  • 通讯作者:
    Andrew Gray

David Nicholls的其他文献

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{{ truncateString('David Nicholls', 18)}}的其他基金

Rapid and Robust High Order Spectral Solvers for Learning Photonic Structures
用于学习光子结构的快速、鲁棒的高阶谱求解器
  • 批准号:
    2111283
  • 财政年份:
    2021
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant
OP: High Accuracy Modeling of Graphene Plasmonics in Three Dimensional Grating Structures
OP:三维光栅结构中石墨烯等离子体的高精度建模
  • 批准号:
    1813033
  • 财政年份:
    2018
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant
Collaborative Research: AFfield Expansion Method for Acoustic Scattering from Topography: Extensions to Elasticity and the Inverse Problem
合作研究:地形声学散射的 AF 场展开方法:弹性和反问题的扩展
  • 批准号:
    1115333
  • 财政年份:
    2011
  • 资助金额:
    $ 18万
  • 项目类别:
    Continuing Grant
Numerical Algorithms for the Detection and Simulation of Surface Water Waves
地表水波检测和模拟的数值算法
  • 批准号:
    0810958
  • 财政年份:
    2008
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant
Reading Charles Ives
读查尔斯·艾夫斯
  • 批准号:
    AH/E003958/1
  • 财政年份:
    2007
  • 资助金额:
    $ 18万
  • 项目类别:
    Research Grant
Free Surface Fluid Mechanics and Electromagnetic Scattering: Stable, High-Order Perturbation Techniques
自由表面流体力学和电磁散射:稳定的高阶扰动技术
  • 批准号:
    0537511
  • 财政年份:
    2005
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant
Free Surface Fluid Mechanics and Electromagnetic Scattering: Stable, High-Order Perturbation Techniques
自由表面流体力学和电磁散射:稳定的高阶扰动技术
  • 批准号:
    0406007
  • 财政年份:
    2004
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant
FRG: Collaborative Research: Fully Nonlinear, Three-Dimensional, Surface Water Waves in Arbitrary Depth
FRG:合作研究:任意深度的完全非线性、三维、表面水波
  • 批准号:
    0139822
  • 财政年份:
    2002
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant
High Order Boundary Perturbation Methods for Boundary Value and Free Boundary Problems
边界值和自由边界问题的高阶边界摄动方法
  • 批准号:
    0196452
  • 财政年份:
    2001
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant
High Order Boundary Perturbation Methods for Boundary Value and Free Boundary Problems
边界值和自由边界问题的高阶边界摄动方法
  • 批准号:
    0072462
  • 财政年份:
    2000
  • 资助金额:
    $ 18万
  • 项目类别:
    Standard Grant

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