MRI: Acquisition of a Solid-State NMR Spectrometer for Chemistry Research Education and Training

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，加州大学洛杉矶分校(UCLA)的Miguel Garcia-Garibay教授及其同事Louis Bouchard、Richard Kaner、Alexander Spokoyny和Jeffery Zink购买了具有固态能力的600 MHz核磁共振波谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及那些可以研究生物相关物种的领域。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果影响到合成有机/无机化学、材料化学和生物化学。该仪器是加州大学洛杉矶分校本科生进行的教学和研究的重要组成部分。这种新的高场核磁共振光谱仪将放置在开放访问的共享仪器设施中，丰富了许多利用固态核磁共振进行研究项目的研究生、博士后研究员和本科生研究人员的研究经验。这项由固体核磁共振支持的研究基础非常广泛，包括材料表征、化学合成、毒理学和仪器分析。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)基于惯性转子和偶极阵列的两栖晶体材料；(B)化学反应流动的原位成像；(C)高通量筛选防污和抗菌涂层；(D)天然存在的蛋白质和其他生物分子，作为金属氧化物纳米颗粒的强健和通用分散剂；(E)无毒纳米颗粒上的阳离子表面涂层，特别是在毒性随着聚合物涂层上的分子量增加而增加的纳米颗粒涂层上；(F)纳米棒的长宽比对细胞吸收的意外影响；(G)可以使用水热方法合成的长度精确控制的二氧化铈纳米线；(H)用于海水淡化的金属表面状态；(I)用于海水淡化的坚固的薄膜；(J)富硼簇合物生产的聚合物；(K)用于捕获和从介孔释放分子的纳米颗粒机器。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Miguel Garcia-Garibay from University of California at Los Angeles (UCLA) and colleagues Louis Bouchard, Richard Kaner, Alexander Spokoyny and Jeffery Zink aquired a 600 MHz NMR spectrometer with solid state capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as those that allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies impact synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students at the University of California at Los Angeles. This new high-field NMR spectrometer, to be placed in an open-access, shared instrumentation facility, enriches the research experiences of the many graduate students, postdoctoral fellows, and undergraduate researchers who pursue research projects utilizing solid-state NMR. The research supported by the use of solid-state NMR is very broad-based, encompassing materials characterization, chemical synthesis, toxicology, and instrumental analysis.The award is aimed at enhancing research and education at all levels, especially in areas such as: (a) amphidynamic crystalline materials based on inertial rotors and dipolar arrays; (b) in situ imaging of chemically reacting flows; (c) high throughput screening of anti-fouling and anti-bacterial coating films; (d) naturally occurring proteins and other biomolecules that act as robust and generalizable dispersing agents for metal oxide nanoparticles; (e) cationic surface coatings on non-toxic nanoparticles that enhance cellular uptake especially those where the toxicity increases with the molecular weight on the polymer coating; (f) the unexpected effect of the aspect ratio of nanorods on cellular uptake; (g) cerium dioxide nanowires of precisely controlled length that can be synthesized using hydrothermal methods; (h) metallic surface states in thalium compounds; (i) robust thin films for desalination; (j) polymers produced from boron-rich clusters; and (k) nanoparticle-based machines for trapping and releasing molecules from mesopores.