MRI: Acquisition of a Solid-State NMR Spectrometer for Chemistry Research Education and Training

在主要研究仪器计划（MRI）的奖励和化学研究仪器计划（CRIF）的支持下，加州大学洛杉矶分校（UCLA）的Miguel Garcia-Garibay教授和他的同事Louis Bouchard、Richard Kaner、Alexander Spokoyny和Jeffery Zink获得了一台具有固态能力的600 MHz核磁共振光谱仪。该光谱仪允许在各种领域的研究，如那些加速具有重要经济意义的化学反应，以及那些允许研究生物相关物种。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果影响了合成有机/无机化学、材料化学和生物化学。该仪器是加州大学洛杉矶分校本科生教学和研究中不可或缺的一部分。这个新的高场核磁共振光谱仪，将被放置在一个开放访问的，共享的仪器设施中，丰富了许多研究生，博士后研究员和本科生的研究经验，他们从事利用固态核磁共振的研究项目。固体核磁共振支持的研究是非常广泛的，包括材料表征，化学合成，毒理学和仪器分析。该奖项旨在加强各级的研究和教育，特别是在以下领域：(a)基于惯性转子和偶极阵列的两动力晶体材料；(b)化学反应流动的原位成像；(c)防污抗菌涂层的高通量筛选；(d)天然存在的蛋白质和其他生物分子，作为金属氧化物纳米颗粒的强大和可推广的分散剂；(e)无毒纳米粒子的阳离子表面涂层，增强细胞摄取，特别是那些毒性随着聚合物涂层上分子量的增加而增加的纳米粒子；(f)纳米棒长径比对细胞摄取的意外影响；(g)长度可精确控制的二氧化铈纳米线，可以用水热法合成；(h)铊化合物的金属表面态；(i)用于海水淡化的坚固薄膜；(j)由富硼团簇产生的聚合物；(k)基于纳米粒子的机器，用于捕获和释放中孔中的分子。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Miguel Garcia-Garibay from University of California at Los Angeles (UCLA) and colleagues Louis Bouchard, Richard Kaner, Alexander Spokoyny and Jeffery Zink aquired a 600 MHz NMR spectrometer with solid state capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as those that allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies impact synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students at the University of California at Los Angeles. This new high-field NMR spectrometer, to be placed in an open-access, shared instrumentation facility, enriches the research experiences of the many graduate students, postdoctoral fellows, and undergraduate researchers who pursue research projects utilizing solid-state NMR. The research supported by the use of solid-state NMR is very broad-based, encompassing materials characterization, chemical synthesis, toxicology, and instrumental analysis.The award is aimed at enhancing research and education at all levels, especially in areas such as: (a) amphidynamic crystalline materials based on inertial rotors and dipolar arrays; (b) in situ imaging of chemically reacting flows; (c) high throughput screening of anti-fouling and anti-bacterial coating films; (d) naturally occurring proteins and other biomolecules that act as robust and generalizable dispersing agents for metal oxide nanoparticles; (e) cationic surface coatings on non-toxic nanoparticles that enhance cellular uptake especially those where the toxicity increases with the molecular weight on the polymer coating; (f) the unexpected effect of the aspect ratio of nanorods on cellular uptake; (g) cerium dioxide nanowires of precisely controlled length that can be synthesized using hydrothermal methods; (h) metallic surface states in thalium compounds; (i) robust thin films for desalination; (j) polymers produced from boron-rich clusters; and (k) nanoparticle-based machines for trapping and releasing molecules from mesopores.