MRI: Acquisition of a Solid-State NMR Spectrometer for Chemistry Research Education and Training

在主要研究仪器计划（MRI）的这一奖项和化学研究仪器计划（CRIF）的支持下，加州大学洛杉矶分校（UCLA）的Miguel Garcia-Garibay教授及其同事Louis Bouchard，Richard Kaner，亚历山大Spokoyny和Jeffery Zink获得了具有固态功能的600 MHz NMR光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应的研究，以及允许研究生物相关物种的研究。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果影响合成有机/无机化学，材料化学和生物化学。该仪器是洛杉矶的加州大学的本科生进行教学和研究的一个组成部分。这种新的高场NMR光谱仪，将被放置在一个开放的，共享的仪器设施，丰富了许多研究生，博士后研究员和本科研究人员谁追求利用固态NMR的研究项目的研究经验。固体核磁共振所支持的研究范围非常广泛，包括材料特性、化学合成、毒理学和仪器分析，该奖项旨在加强各级的研究和教育，特别是在以下领域：（a）基于惯性转子和偶极阵列的双动晶体材料;（B）化学反应流的原位成像;（b）化学反应流的原位成像;（c）化学反应流的原位成像;（d）化学反应流的原位成像;（e）化学反应流的原位成像;（f）化学反应流的原位成像;（g）化学反应流的原位成像。（d）天然存在的蛋白质和其他生物分子，其充当金属氧化物纳米颗粒的稳健和可推广的分散剂;（e）非金属表面的阳离子表面涂层增强细胞摄取的毒性纳米颗粒，特别是其中毒性随聚合物涂层上的分子量而增加的那些;（f）纳米棒的纵横比对细胞摄取的意想不到的影响;（g）可以使用水热方法合成的精确控制长度的二氧化铈纳米线;（h）铊化合物中的金属表面状态;（i）用于脱盐的坚固薄膜;（j）由富硼簇产生的聚合物;和（k）用于从中孔捕获和释放分子的基于纳米颗粒的机器。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Miguel Garcia-Garibay from University of California at Los Angeles (UCLA) and colleagues Louis Bouchard, Richard Kaner, Alexander Spokoyny and Jeffery Zink aquired a 600 MHz NMR spectrometer with solid state capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as those that allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies impact synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students at the University of California at Los Angeles. This new high-field NMR spectrometer, to be placed in an open-access, shared instrumentation facility, enriches the research experiences of the many graduate students, postdoctoral fellows, and undergraduate researchers who pursue research projects utilizing solid-state NMR. The research supported by the use of solid-state NMR is very broad-based, encompassing materials characterization, chemical synthesis, toxicology, and instrumental analysis.The award is aimed at enhancing research and education at all levels, especially in areas such as: (a) amphidynamic crystalline materials based on inertial rotors and dipolar arrays; (b) in situ imaging of chemically reacting flows; (c) high throughput screening of anti-fouling and anti-bacterial coating films; (d) naturally occurring proteins and other biomolecules that act as robust and generalizable dispersing agents for metal oxide nanoparticles; (e) cationic surface coatings on non-toxic nanoparticles that enhance cellular uptake especially those where the toxicity increases with the molecular weight on the polymer coating; (f) the unexpected effect of the aspect ratio of nanorods on cellular uptake; (g) cerium dioxide nanowires of precisely controlled length that can be synthesized using hydrothermal methods; (h) metallic surface states in thalium compounds; (i) robust thin films for desalination; (j) polymers produced from boron-rich clusters; and (k) nanoparticle-based machines for trapping and releasing molecules from mesopores.