MRI: Acquisition of an Upgrade to a Console with Solid State Capabilities for a 14.1 T Magnet

在主要研究仪器计划（MRI）的奖励和化学研究仪器计划（CRIF）的支持下，加州大学河滨分校的Leonard Mueller教授和他的同事William Harman升级了一台600 MHz光谱仪，为它配备了一个14.1特斯拉磁铁的控制台。该仪器还具有固态功能。此次升级为这台600 MHz光谱仪提供了新的电子设备，从而更新了功能，可以在各种领域进行研究，例如那些加速具有重要经济意义的化学反应的领域，以及生物学相关物种的研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，研究溶液或固体状态下分子之间相互作用的动力学。这些核磁共振研究的结果在合成有机/无机化学、材料化学和生物化学等领域具有重要影响。该仪器位于由高素质科学家管理的一般用户设施中，是该西班牙裔服务机构研究、研究培训和教学的一个组成部分。该设施为下一代科学家和工程师提供培训，并扩大了传统上在STEM领域代表性不足的群体的参与。由于加州大学河滨分校是一个全面的核磁共振用户设施，该奖项为该地区较小的学院和大学、私营部门和更广泛的科学界提供了建立外展工作和服务结构的手段。该奖项旨在加强各级的研究和教育，特别是在以下领域：(a)研究typtophan synthase的结构和机制；(b)通过固体核磁共振研究定义良好的多相催化剂；(c)利用N-H共振进行糖胺聚糖表征；(d)表征微观光刻分子晶体；(e)研究配体结合、酶动力学和抑制作用；(f)通过10 - 11易位（Tet1）蛋白的CXXC结构域调节DNA甲基化；(g)利用分子驻极体进行生物激发电荷转移；(h)研究反应性n -杂环硅烯配合物的协同键活化；(1)探索自分选、超分子催化和分子动力学；(j)探索碳硼烷阴离子催化和储能功能；(k)研究抗氧化剂硒氨酸和(l)分离和表征昆虫半化学物质。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Leonard Mueller from the University of California Riverside and colleague William Harman have upgraded a 600 MHz spectrometer by equipping it with a console for a 14.1 Tesla magnet. The instrument also has solid state capabilities. The upgrade provides new electronics and thus updated capabilities to this 600 MHz spectrometer to allow research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules and to study the dynamics of interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument, located in a general user facility managed by highly qualified scientists, is an integral part of research, research training and teaching at this Hispanic Serving Institution. The facility provides training for the next generation of scientists and engineers and broadens the participation of groups traditionally underrepresented in STEM fields. Because the University of California at Riverside is a comprehensive NMR user facility, the award provides the means to establish outreach efforts and service structures to both smaller colleges and universities, the private sector and the broader scientific community in the region.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) studying structure and mechanism in typtophan synthase; (b) studying well-defined heterogeneous catalysts via solid state NMR; (c) exploiting N-H resonances for glycosaminoglycan characterization; (d) characterizing microscopic photomechanical molecular crystals; (e) studying ligand binding, enzyme kinetics and inhibition; (f) regulating DNA methylation by the CXXC domain of the ten-eleven translocation (Tet1) proteins; (g) using molecular electrets for bioinspired charge transfer; (h) studying cooperative bond activation at reactive N-heterocyclic silylene complexes; (i) exploring self-sorting, supramolecular catalysis and molecular dynamics; (j) exploring catalysis and energy storage enabled by carborane anions; (k) studying the antioxidant selenoeine and (l) isolating and characterizing insect semiochemicals.