MRI: Acquisition of an Upgrade to a Console with Solid State Capabilities for a 14.1 T Magnet

MRI：获得具有 14.1 T 磁铁固态功能的升级控制台

• 批准号: 1626673
• 负责人: Leonard Mueller
• 金额: $ 43.09万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1626673&HistoricalAwards=false
• 关键词: MRI; Acquisition; Upgrade; Console; Solid

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Leonard Mueller from the University of California Riverside and colleague William Harman have upgraded a 600 MHz spectrometer by equipping it with a console for a 14.1 Tesla magnet. The instrument also has solid state capabilities. The upgrade provides new electronics and thus updated capabilities to this 600 MHz spectrometer to allow research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules and to study the dynamics of interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument, located in a general user facility managed by highly qualified scientists, is an integral part of research, research training and teaching at this Hispanic Serving Institution. The facility provides training for the next generation of scientists and engineers and broadens the participation of groups traditionally underrepresented in STEM fields. Because the University of California at Riverside is a comprehensive NMR user facility, the award provides the means to establish outreach efforts and service structures to both smaller colleges and universities, the private sector and the broader scientific community in the region.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) studying structure and mechanism in typtophan synthase; (b) studying well-defined heterogeneous catalysts via solid state NMR; (c) exploiting N-H resonances for glycosaminoglycan characterization; (d) characterizing microscopic photomechanical molecular crystals; (e) studying ligand binding, enzyme kinetics and inhibition; (f) regulating DNA methylation by the CXXC domain of the ten-eleven translocation (Tet1) proteins; (g) using molecular electrets for bioinspired charge transfer; (h) studying cooperative bond activation at reactive N-heterocyclic silylene complexes; (i) exploring self-sorting, supramolecular catalysis and molecular dynamics; (j) exploring catalysis and energy storage enabled by carborane anions; (k) studying the antioxidant selenoeine and (l) isolating and characterizing insect semiochemicals.

凭借重大研究仪器计划 (MRI) 的奖项和化学研究仪器计划 (CRIF) 的支持，加州大学河滨分校的 Leonard Mueller 教授和同事 William Harman 升级了 600 MHz 光谱仪，为其配备了 14.1 Tesla 磁铁的控制台。该仪器还具有固态功能。此次升级为这款 600 MHz 光谱仪提供了新的电子设备，从而更新了功能，可用于各种领域的研究，例如加速具有重大经济意义的化学反应的领域，以及生物学相关物种的研究。一般来说，核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。这些核磁共振研究的结果对合成有机/无机化学、材料化学和生物化学产生影响。该仪器位于由高素质科学家管理的普通用户设施中，是该西班牙服务机构研究、研究培训和教学的一个组成部分。该设施为下一代科学家和工程师提供培训，并扩大 STEM 领域传统上代表性不足的群体的参与范围。由于加州大学河滨分校是一个综合性 NMR 用户设施，该奖项为该地区规模较小的学院和大学、私营部门和更广泛的科学界建立外展工作和服务结构提供了手段。该奖项旨在加强各级的研究和教育，特别是在以下领域：(a) 研究色氨酸合酶的结构和机制； (b) 通过固态核磁共振研究明确的多相催化剂； (c) 利用 N-H 共振进行糖胺聚糖表征； (d) 表征微观光机械分子晶体； (e) 研究配体结合、酶动力学和抑制； (f) 通过 10-11 易位 (Tet1) 蛋白的 CXXC 结构域调节 DNA 甲基化； (g) 使用分子驻极体进行仿生电荷转移； (h) 研究反应性 N-杂环亚硅基配合物的协同键活化； (i) 探索自排序、超分子催化和分子动力学； (j) 探索碳硼烷阴离子实现的催化和能量储存； (k) 研究抗氧化剂硒烯和 (l) 分离和表征昆虫化学信息素。