Tumour localisation and enhancement of anthracycline anticancer activity

蒽环类药物是当今应用最广泛的抗癌药物之一。如果这些药物的细胞毒性可以局限于肿瘤细胞，或者它们的活性得到改善，那么这将提高反应率，减少副作用，并改善许多患者的生活质量，对这些患者来说，蒽环类药物治疗是他们治疗的重要组成部分。这将为澳大利亚老龄化人口带来巨大的国家/社区利益，因为澳大利亚人口越来越容易患癌症。

The anthracyclines are one of the most widely used anticancer agents today. If the cytotoxicity of these agents can be localised to tumour cells, or their activity improved, then this will result in improved response rates, less side-effects and an improved quality of life for many patients for whom anthracycline treatment is an important part of their therapy. This will result in enormous national/community benefit to an aging Australian population that is becoming increasingly more prone to cancer.