SBIR Phase II: Nondestructive/noninvasive three-dimensional imaging with Gabor-domain optical coherence microscopy

SBIR 第二阶段：利用 Gabor 域光学相干显微镜进行非破坏性/非侵入性三维成像

• 批准号: 1534701
• 负责人: Cristina Canavesi
• 金额: $ 75万
• 依托单位: LighTopTech Corp.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1534701&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Nondestructive; noninvasive

This Small Business Innovation Research (SBIR) Phase II project will explore the applicability of a Gabor-domain optical coherence microscopy (GD-OCM) instrument to image and evaluate optical materials as part of the manufacturing process. The immediate broader impact of this project is to effectively provide both qualitative and quantitative information about product quality in manufacturing, with an initial focus on contact lens manufacturing. Providing high-speed, industrial, micrometer-level resolution in all three dimensions, GD-OCM enables contact lens manufacturers to replace multiple inspection steps with a single measurement done automatically, reducing the opportunity for damaging the samples and human error, and ultimately leading to increased productivity and yield. The resulting improvements in contact lens performance and extended wear effects are poised to have a positive impact on a significant percentage of the population. Recent evaluations of GD-OCM have indicated its ability to provide a new wealth of characterization methods for quality control of various materials that are otherwise impossible to characterize nondestructively, including gradient refractive index polymers, glass and layered structures. Additionally, GD-OCM will enable new advances in a wide variety of scientific fields via its capability to non-invasively optically section samples of a variety of material types. The objective of this Phase II project is to establish the effectiveness of the emerging GD-OCM technology for nondestructive on-line metrology of contact lenses in manufacturing. Quality control and detection of product-significant defects, and a corresponding increase in production yield, represent the value proposition for the introduction of GD-OCM instrumentation into the contact lens production environment. The project will result in two major outcomes: 1) implementation of a robust production-environment instrument to effectively provide micrometer-level resolution in all three dimensions and quantification of yield-relevant contact lens quality metrics not previously available in a single instrument; and 2) demonstration of the technology for inspection in a production environment to rapidly and accurately monitor defects and quantify contact lens quality using product relevant metrics. This nondestructive, on-line optical inspection system can have significant impact not only on the process control and thereby yield of contact lenses, but also in manufacturing of layered materials in general, including polymers, plastics, and glass. Longer-term, the technology offers new paths for tissue imaging, guided surgery, and monitoring of eye disease.

这个小企业创新研究（SBIR）第二阶段项目将探索Gabor域光学相干显微镜（GD-OCM）仪器的适用性，以成像和评估光学材料作为制造过程的一部分。 该项目的直接广泛影响是有效地提供有关制造过程中产品质量的定性和定量信息，最初重点关注接触透镜制造。GD-OCM在所有三个维度上都提供高速、工业、微米级的分辨率，使接触透镜制造商能够用自动完成的单次测量取代多个检测步骤，减少损坏样品和人为错误的机会，最终提高生产率和产量。 由此产生的接触透镜性能和长期配戴效果的改善有望对相当大比例的人群产生积极影响。 GD-OCM最近的评估表明，它有能力提供一个新的财富的表征方法的质量控制的各种材料，否则不可能非破坏性地表征，包括梯度折射率聚合物，玻璃和层状结构。 此外，GD-OCM将通过其非侵入性光学切片各种材料类型样品的能力，在各种科学领域取得新的进展。该第二阶段项目的目标是确定新兴的GD-OCM技术在隐形眼镜制造过程中的无损在线计量的有效性。产品重大缺陷的质量控制和检测以及产量的相应提高代表了将GD-OCM仪器引入接触透镜生产环境的价值主张。该项目将产生两个主要成果：1）实施一个强大的生产环境仪器，以有效地提供所有三个维度的微米级分辨率，并量化产量相关的接触透镜质量指标，这些指标以前在单一仪器中不可用;和2）演示生产环境中的检测技术，以快速准确地监测缺陷并使用以下技术量化接触透镜质量产品相关指标。这种非破坏性的在线光学检测系统不仅可以对过程控制产生重大影响，从而提高隐形眼镜的产量，而且还可以对一般分层材料（包括聚合物、塑料和玻璃）的制造产生重大影响。从长远来看，该技术为组织成像、引导手术和眼部疾病监测提供了新的途径。