SBIR Phase II: Nondestructive/noninvasive three-dimensional imaging with Gabor-domain optical coherence microscopy

SBIR 第二阶段：利用 Gabor 域光学相干显微镜进行非破坏性/非侵入性三维成像

• 批准号: 1534701
• 负责人: Cristina Canavesi
• 金额: $ 75万
• 依托单位: LighTopTech Corp.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1534701&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Nondestructive; noninvasive

This Small Business Innovation Research (SBIR) Phase II project will explore the applicability of a Gabor-domain optical coherence microscopy (GD-OCM) instrument to image and evaluate optical materials as part of the manufacturing process. The immediate broader impact of this project is to effectively provide both qualitative and quantitative information about product quality in manufacturing, with an initial focus on contact lens manufacturing. Providing high-speed, industrial, micrometer-level resolution in all three dimensions, GD-OCM enables contact lens manufacturers to replace multiple inspection steps with a single measurement done automatically, reducing the opportunity for damaging the samples and human error, and ultimately leading to increased productivity and yield. The resulting improvements in contact lens performance and extended wear effects are poised to have a positive impact on a significant percentage of the population. Recent evaluations of GD-OCM have indicated its ability to provide a new wealth of characterization methods for quality control of various materials that are otherwise impossible to characterize nondestructively, including gradient refractive index polymers, glass and layered structures. Additionally, GD-OCM will enable new advances in a wide variety of scientific fields via its capability to non-invasively optically section samples of a variety of material types. The objective of this Phase II project is to establish the effectiveness of the emerging GD-OCM technology for nondestructive on-line metrology of contact lenses in manufacturing. Quality control and detection of product-significant defects, and a corresponding increase in production yield, represent the value proposition for the introduction of GD-OCM instrumentation into the contact lens production environment. The project will result in two major outcomes: 1) implementation of a robust production-environment instrument to effectively provide micrometer-level resolution in all three dimensions and quantification of yield-relevant contact lens quality metrics not previously available in a single instrument; and 2) demonstration of the technology for inspection in a production environment to rapidly and accurately monitor defects and quantify contact lens quality using product relevant metrics. This nondestructive, on-line optical inspection system can have significant impact not only on the process control and thereby yield of contact lenses, but also in manufacturing of layered materials in general, including polymers, plastics, and glass. Longer-term, the technology offers new paths for tissue imaging, guided surgery, and monitoring of eye disease.

该小型企业创新研究 (SBIR) 第二阶段项目将探索 Gabor 域光学相干显微镜 (GD-OCM) 仪器在制造过程中对光学材料进行成像和评估的适用性。 该项目的直接更广泛影响是有效地提供有关制造过程中产品质量的定性和定量信息，最初的重点是隐形眼镜制造。 GD-OCM 在所有三个维度上提供高速工业微米级分辨率，使隐形眼镜制造商能够用自动完成的单次测量取代多个检测步骤，减少损坏样品和人为错误的机会，最终提高生产率和产量。 由此带来的隐形眼镜性能的改善和长期佩戴效果有望对很大一部分人群产生积极影响。 最近对 GD-OCM 的评估表明，它能够提供大量新的表征方法，用于各种材料的质量控制，否则无法对这些材料进行无损表征，包括梯度折射率聚合物、玻璃和层状结构。 此外，GD-OCM 通过其对各种材料类型的样品进行非侵入性光学切片的能力，将在各种科学领域取得新的进展。该第二阶段项目的目标是确定新兴 GD-OCM 技术在隐形眼镜制造过程中无损在线计量的有效性。质量控制和产品重大缺陷检测以及产量的相应提高代表了将 GD-OCM 仪器引入隐形眼镜生产环境的价值主张。该项目将产生两个主要成果：1）实施强大的生产环境仪器，以有效地在所有三个维度上提供微米级分辨率，并对与良率相关的隐形眼镜质量指标进行量化，这是以前在单一仪器中无法实现的； 2) 演示生产环境中的检测技术，以快速、准确地监控缺陷并使用产品相关指标量化隐形眼镜质量。这种无损在线光学检测系统不仅对过程控制和隐形眼镜的产量产生重大影响，而且对一般层状材料（包括聚合物、塑料和玻璃）的制造也产生重大影响。从长远来看，该技术为组织成像、引导手术和眼部疾病监测提供了新途径。