Collaborative Research: Mechanobiology of a Resilient Bone Extracellular Matrix: A Multiscale Perspective on How Bats Achieve Exceptional Mechanical Properties in their Wing Bones
合作研究:弹性骨细胞外基质的力学生物学:蝙蝠如何在其翼骨中实现卓越机械性能的多尺度视角
基本信息
- 批准号:1537745
- 负责人:
- 金额:$ 34.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-15 至 2019-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Bats are the only mammals capable of powered flight. Bats are also unusual among mammals because their wing bones bend during flight. Some bones bend to almost 90 degrees and do not fracture. However, little is known about how the materials that make up bat bones allow this unusual bending, or the genes that control the deposition and maintenance of this bone tissue. By studying the structure and genetic underpinnings of bat bones compared to terrestrial mammals, this work will show how bone cells work together to create this unusual bone. By building a bat-like bone matrix in a petri dish, it may be possible to get a bioprint of a synthetic material that can bend like bat bones without breaking. Workshops for pre-Kindergarten to high school students about how the bat got its wings have so far reached over 200 students in Northeastern Ohio and this outreach will be continued. Additionally, students around the world will benefit from a newly created educational website. Beyond these workshops, high school, undergraduate, and graduate students working as part of this project will receive interdisciplinary training in molecular, biomechanical, and nanostructural biological techniques. By identifying the mechanisms required to create a resilient extracellular bone matrix in vivo and in vitro, this study is expected to expand our understanding of how bone performance is adjusted by constituent molecular processes and microstructure. We integrate RNA expression and mechanical performance in a flexible bone by undertaking structural and biomechanical analyses (nano-scale to whole bone), as well as in vivo and in vitro molecular assays of limb bone cells of volant and non-volant mammals. Specifically, this result could show how mammalian bone cells can synthesize a bat-like matrix in a 2D culture environment, and eventually allow the synthesis of a specialized 3D matrix in vivo. Overall this study will allow for multiple fields of research to understand and capitalize on what evolution selected as the key mechanisms needed to make an unusually flexible bone.
蝙蝠是唯一能够动力飞行的哺乳动物。 蝙蝠在哺乳动物中也很不寻常,因为它们的翼骨在飞行时会弯曲。 有些骨头弯曲到几乎90度也不会骨折。 然而,人们对构成蝙蝠骨骼的材料如何允许这种不寻常的弯曲,或者控制这种骨组织沉积和维持的基因知之甚少。 通过研究蝙蝠骨骼与陆地哺乳动物相比的结构和遗传基础,这项工作将展示骨细胞如何共同创造这种不寻常的骨骼。 通过在培养皿中构建蝙蝠状骨基质,有可能获得一种合成材料的生物打印,这种材料可以像蝙蝠骨一样弯曲而不会断裂。到目前为止,在俄亥俄州东北部,为幼儿园前到高中学生举办的关于蝙蝠如何长出翅膀的讲习班已经吸引了200多名学生,这种宣传活动将继续下去。此外,世界各地的学生将受益于一个新创建的教育网站。 除了这些研讨会,高中,本科和研究生作为该项目的一部分工作将接受分子,生物力学和纳米结构生物技术的跨学科培训。 通过确定在体内和体外产生弹性细胞外骨基质所需的机制,这项研究有望扩大我们对骨性能如何通过组成分子过程和微观结构调节的理解。 我们通过进行结构和生物力学分析(纳米级至整个骨骼),以及对会飞翔和不会飞翔的哺乳动物的肢体骨细胞进行体内和体外分子测定,将RNA表达和机械性能整合到柔性骨骼中。具体来说,这一结果可以显示哺乳动物骨细胞如何在2D培养环境中合成蝙蝠样基质,并最终允许在体内合成专门的3D基质。 总的来说,这项研究将允许多个研究领域来理解和利用进化选择的关键机制来制造异常灵活的骨骼。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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Lisa Noelle Cooper其他文献
Limited Cell-Autonomous Anticancer Mechanisms in Long-Lived Bats
长寿蝙蝠的有限细胞自主抗癌机制
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Fathima Athar;Zhizhong Zheng;Sébastien Riquier;Max Zacher;Dominic Alcock;A. Galazyuk;Lisa Noelle Cooper;T. Schountz;Lin;E. Teeling;A. Seluanov;Vera Gorbunova - 通讯作者:
Vera Gorbunova
Integrative imaging of the developing opossum cochlea
- DOI:
10.1016/j.ydbio.2010.05.398 - 发表时间:
2010-08-01 - 期刊:
- 影响因子:
- 作者:
Lisa Noelle Cooper;Karen E. Sears - 通讯作者:
Karen E. Sears
Lisa Noelle Cooper的其他文献
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