NSF/FDA SIR: Multimodal characterization of quantitative biomarkers for traumatic brain injury measured via portable device technology

该提案的驱动目标是需要一种能够量化创伤性脑损伤（TBI）生物标志物的便携式设备，重点是确定脑电图（EEG）和弥散相关光谱（DCS）在动物模型中检测TBI生物标志物的效用。创伤性脑损伤是军民医学中一个非常重要的问题。TBI患者的诊断和评估通常使用临床成像方式（MRI， CT）。然而，未来可用于评估TBI的便携式设备将从根本上改善TBI患者的前景。由于缺乏可量化的生物标志物，TBI的诊断和治疗受到监管科学空白的阻碍。两个互补的测量参数有可能填补这一空白。(1)体感诱发电生理电位（ssep）测量；(2)漫射相关光谱（DCS）。本提案旨在评估这些参数在动物模型中检测TBI的效用，而不需要基线，损伤前测量。

PI: Fisher, Jonathan Proposal Number:1541612 This proposal, whose driving goal is the need for a portable device capable of quantifying biomarkers of traumatic brain injury (TBI), focuses on determining the utility of Electroencephalography (EEG) and Diffuse Correlation Spectrography (DCS) for detecting TBI biomarkers in an animal model. TBI is a very significant issue in both military and civilian medicine. Diagnosis and assessment of TBI patients is generally performed using clinical imaging modalities (MRI, CT). However, the future availability of portable devices for assessing TBI would fundamentally improve the outlook for TBI patients. The diagnosis and treatment of TBI is impeded by gaps in regulatory science due to a lack of quantifiable biomarkers. Two complementary measurement parameters have potential to fill this gap. (1) measurement of somatosensory evoked electrophysiological potentials (SSEPs); and (2) diffuse correlation spectroscopy (DCS). This proposal seeks to evaluate the utility of these parameters for detecting TBI in an animal model without the need for a baseline, pre-injury measurement.