NSF/FDA SIR: Micro- and macro-scale validation of diffuse correlation spectroscopy for monitoring functional hemodynamics in the microvasculature of the cerebral cortex

NSF/FDA SIR：漫相关光谱学的微观和宏观验证，用于监测大脑皮层微脉管系统的功能性血流动力学

• 批准号: 1641133
• 负责人: Jonathan Fisher
• 金额: $ 7.99万
• 依托单位: New York Medical College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-11-01 至 2017-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1641133&HistoricalAwards=false
• 关键词: NSF; FDA; SIR; Micro; macro

PI: Fisher, JonathanProposal Number: 1641133Existing monitoring methods have technological limitations, such as the inability to detect flow changes in small blood vessels, as well as practical ones, such as portability and safety issues involved in bedside monitoring. Cost is an additional limitation for current clinical diagnostics; small hospitals often do not have such capabilities. Transcranial optical techniques such as diffuse correlation spectroscopy (DCS) can provide rapid, real-time monitoring of brain activity for a fraction of the cost of other methods. The PI will evaluate diffuse correlation spectroscopy (DCS) as a noninvasive optical methods for monitoring real-time changes in cerebral blood flow. The proposed research will partner researchers, faculty and postdocs at the New York Medical College, the University of Colorado, the University of Pennsylvania, and the FDA. The proposal includes a well-designed mentoring plan to be implemented by the PI. The plan includes tracking progress through Individual Development Plans; informal discussions to assess satisfaction with the mentoring program' and tracking progress toward career goals.This project will provide information on the types of changes that can be interrogated using the low-resolution diffuse correlation spectroscopy (DCS) technique. Direct comparison to a high resolution technique will provide necessary information on sensitivity and specificity for DCS. The use of stimulated changes during monitoring will provide the types of necessary detail on the populations of blood vessels that can be assessed. Cerebral blood flow can be used to inform medical interventions in cases of neurological injury or disease.

主要研究者：Fisher，Jonathan提案编号：1641133现有的监测方法有技术上的局限性，例如不能检测小血管中的血流变化，也有实用性的局限性，例如床旁监测涉及的便携性和安全性问题。成本是目前临床诊断的另一个限制因素;小医院往往没有这种能力。经颅光学技术，如扩散相关光谱（DCS），可以提供快速，实时监测大脑活动的一小部分，成本的其他方法。PI将评价弥散相关光谱（DCS）作为监测脑血流实时变化的无创光学方法。这项拟议中的研究将与纽约医学院、科罗拉多大学、宾夕法尼亚大学和FDA的研究人员、教师和博士后合作。该提案包括一个精心设计的指导计划，由PI实施。该计划包括通过个人发展计划跟踪进展;非正式讨论以评估对指导计划的满意度，并跟踪职业目标的进展。该项目将提供有关可以使用低分辨率扩散相关光谱（DCS）技术询问的变化类型的信息。与高分辨率技术的直接比较将为DCS的灵敏度和特异性提供必要的信息。在监测期间使用刺激变化将提供关于可以评估的血管群的必要细节类型。脑血流量可用于在神经损伤或疾病的情况下通知医疗干预。