Dissecting microvascular underpinnings of injury-induced alterations in functional cerebral blood flow

这项提案将致力于确定创伤性脑损伤(TBI)的非侵入性标志物。该提案列出了一项计划，以验证轻微(M)脑损伤的定量生物标记物，这些标记物在受伤后几周内持续存在。这项拟议的研究将与纽约医学院、科罗拉多大学、宾夕法尼亚大学和FDA的教职员工和博士后合作。该提案包括由首席调查员实施的精心设计的指导计划。该计划包括通过个人发展计划跟踪进展情况；通过非正式讨论评估对指导计划的满意度，以及跟踪实现职业目标的进展情况。首席研究人员将评估漫相关光谱作为一种非侵入性光学方法来监测脑血流的实时变化，以便在发生神经损伤或疾病时更好地为医疗干预提供信息。该项目将提供有关可使用低分辨率漫反射相关光谱技术询问的变化类型的信息。与高分辨率技术的直接比较将提供有关分布式控制系统的敏感性和特异性的必要信息。在监测过程中使用刺激变化将提供可评估的血管种群的必要细节类型。在神经损伤或疾病的情况下，脑血流可用于为医疗干预提供信息。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This proposal will work on identifying non-invasive markers for traumatic brain injury (TBI). The proposal lays out a plan to verify quantitative biomarkers for mild (m)TBI that persist in the weeks following an injury. The proposed research will partner with faculty and postdocs at the New York Medical College, the University of Colorado, the University of Pennsylvania, and the FDA. The proposal includes a well-designed mentoring plan to be implemented by the principal investigator. The plan includes tracking progress through Individual Development Plans; informal discussions to assess satisfaction with the mentoring program' and tracking progress toward career goals. The principal investigator will evaluate diffuse correlation spectroscopy as a noninvasive optical method for monitoring real-time changes in cerebral blood flow, in order to better inform medical interventions in the event of neurological injury or disease. This project will provide information on the types of changes that can be interrogated using the low-resolution diffuse correlation spectroscopy (DCS) technique. Direct comparison to a high resolution technique will provide necessary information on sensitivity and specificity for DCS. The use of stimulated changes during monitoring will provide the types of necessary detail on the populations of blood vessels that can be assessed. Cerebral blood flow can be used to inform medical interventions in cases of neurological injury or disease.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.