Decoding dynamic abnormalities in cerebral hemodynamic responses obtained from near-infrared optical diagnostics

解码近红外光学诊断获得的脑血流动力学反应的动态异常

• 批准号: 1743661
• 负责人: Jonathan Fisher
• 金额: $ 8.79万
• 依托单位: New York Medical College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-15 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1743661&HistoricalAwards=false
• 关键词: Decoding; dynamic; abnormalities; cerebral; hemodynamic

The principal investigator will evaluate diffuse correlation spectroscopy as a noninvasive optical method for monitoring real-time changes in cerebral blood flow, in order to better inform medical interventions in the event of neurological injury or disease. The proposed research will partner researchers, faculty and postdocs at the New York Medical College, the University of Colorado, the University of Pennsylvania, and the FDA. The proposal includes a well-designed mentoring plan to be implemented by the PI. The plan includes tracking progress through Individual Development Plans; informal discussions to assess satisfaction with the mentoring program' and tracking progress toward career goals. This project will provide information on the types of changes that can be interrogated using the low-resolution diffuse correlation spectroscopy (DCS) technique. Direct comparison to a high resolution technique will provide necessary information on sensitivity and specificity for DCS. The use of stimulated changes during monitoring will provide the types of necessary detail on the populations of blood vessels that can be assessed. Cerebral blood flow can be used to inform medical interventions in cases of neurological injury or disease.

主要研究者将评估弥散相关光谱作为监测脑血流实时变化的无创光学方法，以便在神经损伤或疾病的情况下更好地通知医疗干预。这项拟议中的研究将与纽约医学院、科罗拉多大学、宾夕法尼亚大学和FDA的研究人员、教师和博士后合作。该提案包括一个精心设计的指导计划，由PI实施。该计划包括通过个人发展计划跟踪进展;非正式讨论，以评估对指导计划的满意度，并跟踪职业目标的进展。该项目将提供关于可以使用低分辨率扩散相关光谱技术进行查询的变化类型的信息。与高分辨率技术的直接比较将为DCS的灵敏度和特异性提供必要的信息。在监测期间使用刺激变化将提供关于可以评估的血管群的必要细节类型。脑血流量可用于在神经损伤或疾病的情况下通知医疗干预。