Science and Technology Center for Engineering Mechano-Biology

工程力生物学科技中心

• 批准号: 1548571
• 负责人: Vivek Shenoy
• 金额: $ 2363.95万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-10-01 至 2026-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1548571&HistoricalAwards=false
• 关键词: Science; Technology; Center; Engineering; Mechano

The Science and Technology Center for Engineering Mechano-Biology (CEMB) brings together leading researchers from a diverse group of disciplines and institutions to investigate, understand, and innovate at the intersection of biology, mechanics, and engineering. The mission of this Center is to discover the governing principles of molecular and cellular communication, provide the intellectual foundations and materials for engineering new and powerful cell-based devices, and to train students in the multilingual foundations of engineering mechano-biology preparing them to be innovative leaders able to explore and exploit these interconnections to impact society. This award supports an innovative network of researchers and educators to investigate the fundamental relationships between cells, their environment, and the forces that act upon them. The team will train a new generation of scientists and engineers in the emerging discipline of Mechano-biology, and will partner with industry to translate new scientific discoveries into products and solutions for the health and prosperity of the nation.Engineering Mechano-biology, with its focus on the interactions between structure, mechanics, and function, will have a major impact on our ability to construct and repair tissues, organs, and implants; to adapt plants to changing environments; to treat inflammation and fibrosis; to understand the effects of exercise, activity, and trauma; and to engineer optimized synthetic and biomimetic materials. This interdisciplinary field will enable fundamental discoveries in biological function and spur the development of cutting edge technologies for interrogation and guidance of plant and animal structures on multiple scales. Projects will span the length and time scales over which forces operate: from single molecules to supramolecular complexes, cells, tissues and whole organisms, and from milliseconds to hours, weeks or months. Major research efforts will focus on three Integrated Research Thrusts (IRTs) requiring new interfaces across disciplines and organized following a cell's hierarchical perspective from mechano-responsive molecules to signaling pathways to the extracellular niche. Thrust 1: Mechano-biology of Biomolecules and Nanostructures will characterize and engineer proteins and molecules, enabling detection and manipulation of the pN and nm mechano-responsiveness of proteins, scaffolds, and cells to probe or generate increasingly complex engineered mechano-biological reagents, materials, and systems. Thrust 2: Mechano-biology of Cells and Signaling will elucidate how cells dynamically react to mechanical forces through feedback between the cytoskeleton, the nucleus and the surrounding matrix, uncover the ways mechano-signaling contributes to cell-cell communication, and discover how cells distinguish and integrate mechano-signals across length and time scales. Thrust 3: Mechano-biology of Tissues, Materials and Microenvironments will identify matrix-based mechanical cues in plants and animals and investigate the fabrication of bulk gels, fibrous networks, and engineered micro-devices. This will lead to the generation of materials with mechano-responsive properties as well as novel means for studying the structural and biophysical cues in mechano-transduction.

工程机械生物学科学技术中心（CEMB）汇集了来自不同学科和机构的领先研究人员，以研究，理解和创新生物学，力学和工程的交叉点。 该中心的使命是发现分子和细胞通信的管理原则，为工程新的和强大的细胞为基础的设备提供知识基础和材料，并培养学生在工程机械生物学的多语言基础，使他们成为能够探索和利用这些相互联系影响社会的创新领导者。该奖项支持研究人员和教育工作者的创新网络，以调查细胞，其环境和作用于它们的力量之间的基本关系。该团队将在新兴的机械生物学学科中培养新一代的科学家和工程师，并将与工业界合作，将新的科学发现转化为产品和解决方案，以促进国家的健康和繁荣。工程机械生物学，其重点是结构，力学和功能之间的相互作用，将对我们构建和修复组织，器官，和植入物;使植物适应不断变化的环境;治疗炎症和纤维化;了解运动、活动和创伤的影响;设计优化的合成和仿生材料。这一跨学科领域将使生物功能的基本发现，并刺激尖端技术的发展，用于在多个尺度上询问和指导植物和动物结构。项目将跨越力作用的长度和时间尺度：从单分子到超分子复合物、细胞、组织和整个生物体，从毫秒到小时、周或月。主要的研究工作将集中在三个综合研究重点（IRT），需要跨学科的新接口，并按照细胞的层次结构从机械响应分子到信号通路到细胞外生态位的角度进行组织。推力1：生物分子和纳米结构的机械生物学将表征和设计蛋白质和分子，使蛋白质，支架和细胞的pN和nm机械响应性的检测和操作能够探测或产生越来越复杂的工程机械生物学试剂，材料和系统。推力二：细胞和信号的机械生物学将阐明细胞如何通过细胞骨架，细胞核和周围基质之间的反馈动态地对机械力作出反应，揭示机械信号有助于细胞间通信的方式，并发现细胞如何区分和整合机械信号跨越长度和时间尺度。推力3：组织，材料和微环境的机械生物学将识别植物和动物中基于基质的机械线索，并研究散装凝胶，纤维网络和工程微器件的制造。这将导致产生材料的机械响应特性，以及新的手段，研究结构和生物物理线索的机械转导。