EAGER: GOALI: Perfluoro(poly)ethers - a new class of drinking water contaminants

1550222 knappe长链全氟烷基物质，如全氟辛酸和全氟辛烷磺酸，由于其持久性、生物蓄积潜力和（生态）毒性，正在被短链氟化替代品取代。几乎没有关于氟替代品的出现及其在水处理过程中的行为的信息。拟议研究的总体目标是通过研究一类氟化替代品，即全氟（聚）醚，开始填补这一知识空白。具体研究目标包括：(1)开发一种定量液相色谱-串联质谱法，用于分析水中的13种全氟（聚）醚；(2)应用液相色谱-串联质谱法(a)确定地表水中的全氟（聚）醚的去向；(b)定量水处理厂进水口的全氟（聚）醚浓度和质量流量；(3)与自来水公司合作，(4)通过配水系统对包水进行追踪，以确定饮用水配水过程中全氟（聚）醚的去向。这些数据将用于估计人类通过饮用饮用水接触全氟（聚）醚的情况。鉴于有关氟化替代品的数据匮乏，预计这项研究的结果将受到广泛关注。

1550222KnappeBecause of their persistence, bioaccumulation potential, and (eco)toxicity, long-chain perfluoroalkyl substances such as perfluorooctanoic acid and perfluorooctane sulfonate are being replaced with short-chain fluorinated alternatives. Almost no information exists about the occurrence of fluorinated alternatives and their behavior during water treatment. The overall goal of the proposed research is to begin to fill this knowledge gap by studying one class of fluorinated alternatives, perfluoro(poly) ethers. Specific research objectives include to: (1) develop a quantitative liquid chromatography-tandem mass spectrometry method for the analysis of 13 perfluoro(poly) ethers in water, (2) apply the liquid chromatography-tandem mass spectrometry method to (a) determine perfluoro(poly) ether fate in a surface water, (b) quantify perfluoro(poly) ether concentrations and mass flows at the intake of a water treatment plant, (3) in collaboration with the water utility, trace parcels of water through the plant to quantify perfluoro(poly) ether removal/transformation in full-scale water treatment processes, and (4) trace parcels of water through the water distribution system to determine perfluoro(poly) ethers fate during drinking water distribution. This data would be used to estimate human exposure to perfluoro(poly) ethers via consumption of drinking water. Given the data scarcity surrounding fluorinated alternatives, it is anticipated that the results of this research will receive wide interest.