EAGER: Neural dust stimulation for closed loop neuromodulation

提案编号：1551239，EAGER-闭环神经调节的神经粉尘刺激神经工程中仍然存在的最重要的挑战之一是开发和证明临床上可行的神经接口，该接口可以记录和刺激许多单个神经元，并持续一生。这些慢性或长期的神经接口越来越受到中枢（CNS）和外周神经系统（PNS）干预的关注。创建持久、耐用、不受束缚的界面会引发各种问题，从物理基底的性质（避免可能导致电极-组织界面处性能退化的生物和非生物效应，感测部位的密度和空间覆盖），测量的信号类型，以及在整个系统的功率预算下的计算和通信能力（无线传输多少信号处理片上数据）。该提案旨在扩展我们最近发布的神经尘埃平台，以允许通过神经尘埃刺激神经。我们相信这是一个积极的愿景，它将为大量的干预措施打开大门，包括人类神经和神经元的无束缚神经记录，这些过程的无束缚刺激以及记录和刺激闭环系统。这一愿景将需要一些基础技术创新，这些创新将对基础神经科学、神经系统疾病的临床干预和假肢等领域产生影响。例如，利用微创医疗设备精确监测和调节外周神经活动的能力将实现广泛的治疗机会。这种闭环神经调节不能用现有技术完成，因为它们存在两个主要缺点之一：缺乏空间分辨率或高度侵入性。我们最近提出了一种超微型且非常兼容的系统，可以大规模扩展来自大脑或外周神经系统的记录数量，为真正的慢性BMI提供了一条道路。这一愿景的核心是一个平台，用于从外周神经内部向体外供电、接收和传输信息，使用积极的、最先进的电路设计，以及最近展示的超声波、压电晶体“神经尘埃”？微粒。该提案中设想的工作将利用最近的专用集成电路（ASIC）技术来构建刺激微粒，这些微粒可以处理单个神经元（或外周纤维），并将展示神经纤维的无束缚刺激，为使用神经粉尘的闭环记录和刺激技术铺平道路。这是一个非常积极、高风险的方向，它利用了现有的神经尘埃开发，具有非常高的潜在回报（因为它实现了无约束的闭环神经调节系统）。 我们的长期愿景是一个能够记录和刺激闭环的系统。

Proposal No:1551239, EAGER-Neural dust stimulation for closed loop neuromodulationOne of the most important challenges that remains in neuroengineering is the development and demonstration of a clinically viable neural interface which can both record from and stimulate many individual neurons and lasts a lifetime. These chronic or long-term neural interfaces are of increasing interest for both central (CNS) and peripheral nervous system (PNS) interventions. Creating lasting, durable, untethered interfaces raises a variety of issues, ranging from the nature of the physical substrate (avoiding the biotic and abiotic effects that presumably lead to performance degradation at the electrode-tissue interface, the density and spatial coverage of the sensing sites), the type of signals measured, and the computation and communication capabilities (how much signal processing on-chip data to transmit wirelessly) under the power budget of the whole system. This proposal seeks to extend our recently published Neural Dust platform to allow for stimulation of nerves via neural dust motes. We believe this to be an aggressive vision which would open the door to a vast array of interventions, including untethered neural recording of human nerves and neurons, untethered stimulation of these processes and record-and-stimulate closed loop systems. Such a vision will require a number of fundamental technological innovations that will have impact across domains including basic neuroscience, clinical interventions of neurological disorders, and prosthetics. For example, the ability to precisely monitor and modulate peripheral nerve activity with a minimally invasive medical device would enable a wide-range of therapeutic opportunities. This closed-loop neuromodulation cannot be done with existing technologies because they suffer from one of two major drawbacks: lack of spatial resolution or high degree of invasiveness. We recently proposed an ultra-miniature as well as extremely compliant system that could enable massive scaling in the number of recordings from the brain or the peripheral nervous system, providing a path towards truly chronic BMI. At the core of this vision is a platform for powering, receiving and transmitting information from inside a peripheral nerve to outside the body using aggressive, state-of-the-art circuit design and the recent demonstration of ultrasonic, piezocrystal "neural dust? motes. The work envisioned in this proposal will leverage recent application specific integrated circuit (ASIC) technology to build stimulating motes that can address individual neurons (or peripheral fibers) and will demonstrate untethered stimulation of nerve fibers, paving the way to closed-loop record-and-stim technology using neural dust. This is a very aggressive, high risk direction which leverages existing neural dust developments with a very high potential payoff (as it enables untethered closed-loop neuromodulation systems). Our long term vision is a system capable of recording and stimulation in closed-loop.